| Project/Area Number |
18H02944
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 56040:Obstetrics and gynecology-related
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| Research Institution | University of Fukui |
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Principal Investigator |
YOSHIDA Yoshio 福井大学, 学術研究院医学系部門, 教授 (60220688)
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| Co-Investigator(Kenkyū-buntansha) |
辻川 哲也 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
清野 泰 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
岡沢 秀彦 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
水谷 哲也 福井県立大学, 看護福祉学部, 教授 (90322734)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 婦人科腫瘍学 / 子宮肉腫 / 肺転移 / Radiogenomics / 原発巣-転移巣細胞間コミュニケーション / exosome / プラズマゲルソリン / Radiogenomics解析 / 遺伝子プロファイリング / 肺転移マウスモデル / 同所移植法を用いた子宮肉腫・肺転移解析モデル / 画像プロファイル / ゲノムワイド遺伝子発現プロファイル / Radiogenomics法 / 新規の非侵襲的な子宮肉腫診断・治療法 / Texture解析 / 子宮肉腫肺転移解析モデル |
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| Outline of Final Research Achievements |
We found that GDF15, Progranulin, and Osteopontin are secreted proteins that are specifically highly expressed in early-stage uterine sarcoma. The regulatory genes of these secreted proteins were also found to be the genes that control exosome secretion. These findings suggest that exosomes are secreted from the primary tumor from an early stage in uterine sarcoma, and that exosomes play a major role in the acquisition of a protective environment in uterine sarcoma through active communication between primary tumor and metastatic tumor cells.In vivo uterine sarcoma "Radiomics" analysis showed that the higher-order textural features of Complementarity and Strength were specific to metastases.These findings suggest that the expression of Complementarity and Strength higher-order texture features in metastases may be a biomarker for the therapeutic effect of anti-esosome administration in uterine sarcoma.
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| Academic Significance and Societal Importance of the Research Achievements |
難治性、子宮肉腫症例に対する新たなバイオマーカーの樹立と子宮肉腫における抗exosome抗体投与における治療効果の可能性が示唆された
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