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Investigation of immune-suppressive dynamism and exploratory research for new treatment strategy for gynecologic cancer

Research Project

Project/Area Number 18H02945
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionKyoto University

Principal Investigator

Hamanishi Junzo  京都大学, 医学研究科, 講師 (80378736)

Co-Investigator(Kenkyū-buntansha) 万代 昌紀  京都大学, 医学研究科, 教授 (80283597)
安彦 郁  独立行政法人国立病院機構(京都医療センター臨床研究センター), 内分泌代謝高血圧研究部, 研究員 (20508246)
村上 隆介  滋賀県立総合病院(研究所), その他部局等, 医長 (40782363)
茶本 健司  京都大学, 医学研究科, 特定准教授 (50447041)
Brown John  京都大学, 医学研究科, 講師 (90583188)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords婦人科腫瘍 / 免疫ダイナミズム / 免疫チェックポイント / 卵巣癌 / 腫瘍免疫 / 婦人科がん / 免疫ゲノミクス / 子宮体癌 / PD-1 / 免疫ダイナミクス / PD-L1
Outline of Final Research Achievements

In this study, we used mouse ovarian and uterine cancer models to demonstrate that antitumor effects of conventional chemotherapies cancer drugs and immune checkpoint inhibition via dynamic change of not only tumor cells but also several immune cells and immune-related factors. In addition, we also identified several factors that induce or inhibit certain types of immune cells fractionation, which were not found in our previous studies, and confirmed that these factors enhance the anti-tumor effect when used in combination with conventional chemotherapy and immune checkpoint inhibitors in a mouse tumor-bearing models.

Academic Significance and Societal Importance of the Research Achievements

婦人科腫瘍は、初回治療には反応しやすいが、再発症例や1次治療が無効となると有効な2次治療がないため予後不良であったが、従来の治療に上乗せ効果を示す可能性が示唆された。そのため、本研究の成果によって、婦人科腫瘍患者の予後改善に大きく寄与するとともに、がん腫横断的に幅広く有効性を示す可能性が高いため、様々ながん種における研究・治療全般への波及効果が期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (70 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (27 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (32 results) (of which Int'l Joint Research: 7 results,  Invited: 27 results) Book (8 results) Remarks (2 results)

  • [Int'l Joint Research] Chicago University(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition.2021

    • Author(s)
      Taki M, Abiko K, Ukita M, Murakami R, Yamanoi K, Yamaguchi K, Hamanishi J, Baba T, Matsumura N, Mandai M.
    • Journal Title

      Clin Cancer Res

      Volume: - Issue: 17 Pages: 4459-4459

    • DOI

      10.1158/1078-0432.ccr-20-4459

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] UGT1A1 polymorphism has a prognostic effect in patients with stage IB or II uterine cervical cancer and one or no metastatic pelvic nodes receiving irinotecan chemotherapy: a retrospective study2020

    • Author(s)
      Matsuoka Hideki、Murakami Ryusuke、Abiko Kaoru、Yamaguchi Ken、Horie Akihito、Hamanishi Junzo、Baba Tsukasa、Mandai Masaki
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 729-729

    • DOI

      10.1186/s12885-020-07225-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-VEGF therapy resistance in ovarian cancer is caused by GM-CSF-induced myeloid-derived suppressor cell recruitment.2020

    • Author(s)
      Horikawa N, Abiko K, Matsumura N, Baba T, Hamanishi J, Yamaguchi K, Murakami R, Taki M, Ukita M, Hosoe Y, Koshiyama M, Konishi I, Mandai M.
    • Journal Title

      Br J Cancer.

      Volume: 122(1) Issue: 6 Pages: 778-788

    • DOI

      10.1038/s41416-019-0725-x

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic utility of FDG PET/CT in advanced ovarian, fallopian and primary peritoneal high-grade serous cancer patients before and after neoadjuvant chemotherapy.2020

    • Author(s)
      Watanabe M, Nakamoto Y, Ishimori T, Saga T, Kido A, Hamanishi J, Hamanaka Y, Togashi K.
    • Journal Title

      Ann Nucl Med.

      Volume: 34 Issue: 2 Pages: 128-135

    • DOI

      10.1007/s12149-019-01424-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquisition of a side population fraction augments malignant phenotype in ovarian cancer.2019

    • Author(s)
      Yamanoi K, Baba T, Abiko K, Hamanishi J, Yamaguchi K, Murakami R, Taki M, Hosoe Y, Murphy SK, Konishi I, Mandai M, Matsumura N.
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 14215-14215

    • DOI

      10.1038/s41598-019-50794-w

    • NAID

      120006822513

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma.2019

    • Author(s)
      Goto M, Chamoto K, Higuchi K, Yamashita S, Noda K, Iino T, Miura M, Yamasaki T, Ogawa O, Sonobe M, Date H, Hamanishi J, Mandai M, Tanaka Y, Chikuma S, Hatae R, Muto M, Minamiguchi S, Minato N, Honjo T
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 10144-10144

    • DOI

      10.1038/s41598-019-46548-3

    • NAID

      120006724630

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphorylation of STAT1 Serine 727 Enhances Platinum Resistance in Uterine Serous Carcinoma.2019

    • Author(s)
      Zeng X, Baba T, Hamanishi J, Matsumura N, Budiman K, Mise Y, Abiko K, Yamaguchi K, Horikawa N, Huntsman DG, Mulati K, Kitamura S, Taki M, Murakami R, Hosoe Y, Mandai M.
    • Journal Title

      Int J Cancer.

      Volume: 145(6) Issue: 6 Pages: 1635-1647

    • DOI

      10.1002/ijc.32501

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] がん免疫の最前線 免疫チェックポイント阻害薬2019

    • Author(s)
      濱西 潤三, 万代 昌紀
    • Journal Title

      BIO Clinica

      Volume: 34 Pages: 15-19

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 【がん免疫療法の個別化を支える 新・腫瘍免疫学】第II部 がん免疫療法の臨床開発における課題と対応 (第3章)免疫療法のリバーストランスレーショナル研究 婦人科がん(子宮体がん・子宮頸がん・卵巣がん)(解説/特集)2019

    • Author(s)
      濱西 潤三, 万代 昌紀
    • Journal Title

      実験医学

      Volume: 37 Pages: 2608-2614

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 【ご存じですか? 産婦人科領域で話題の薬物療法】婦人科がんに対する免疫チェックポイント阻害薬(解説/特集)2019

    • Author(s)
      濱西 潤三, 万代 昌紀
    • Journal Title

      産婦人科の実際

      Volume: 68 Pages: 379-389

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 本庶佑教授(BIO Clinica編集顧問)ノーベル生理学・医学賞受賞によせて 本庶佑教授のノーベル医学・生理学賞に際して2019

    • Author(s)
      濱西 潤三
    • Journal Title

      BIO Clinica

      Volume: 34 Pages: 6-7

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 【婦人科腫瘍の新たな治療戦略】卵巣がんの新たな治療戦略 免疫チェックポイント阻害薬2019

    • Author(s)
      濱西 潤三, 万代 昌紀
    • Journal Title

      Pharma Medica

      Volume: 37 Pages: 25-31

    • Related Report
      2019 Annual Research Report
  • [Journal Article] PD-1経路を標的にしたがん治療の躍進 (本庶佑博士の2018年ノーベル生理学・医学賞受賞)2019

    • Author(s)
      濵西 潤三
    • Journal Title

      学術の動向

      Volume: 24 Pages: 20-24

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 「卵巣癌・卵管癌・腹膜癌:分子生物学的背景と分子標的薬」2019

    • Author(s)
      濱西 潤三, 万代 昌紀
    • Journal Title

      医学のあゆみ 別冊

      Volume: 5 Pages: 89-96

    • Related Report
      2019 Annual Research Report
  • [Journal Article] VISTA expressed in tumour cells regulates T cell function2018

    • Author(s)
      Mulati Kumuluzi、Hamanishi Junzo、Matsumura Noriomi、Chamoto Kenji、Mise Nathan、Abiko Kaoru、Baba Tsukasa、Yamaguchi Ken、Horikawa Naoki、Murakami Ryusuke、Taki Mana、Budiman Kharma、Zeng Xiang、Hosoe Yuko、Azuma Miyuki、Konishi Ikuo、Mandai Masaki
    • Journal Title

      British Journal of Cancer

      Volume: 120 Issue: 1 Pages: 115-127

    • DOI

      10.1038/s41416-018-0313-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomics to immunotherapy of ovarian clear cell carcinoma: Unique opportunities for management.2018

    • Author(s)
      Oda K, Hamanishi J, Matsuo K, Hasegawa K
    • Journal Title

      Gynecol Oncol

      Volume: 151 Issue: 2 Pages: 381-389

    • DOI

      10.1016/j.ygyno.2018.09.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Antitumor Effect of Nivolumab on Subsequent Chemotherapy for Platinum‐Resistant Ovarian Cancer2018

    • Author(s)
      Inayama Yoshihide、Hamanishi Junzo、Matsumura Noriomi、Murakami Ryusuke、Abiko Kaoru、Yamaguchi Ken、Baba Tsukasa、Horie Katsuyuki、Konishi Ikuo、Mandai Masaki
    • Journal Title

      The Oncologist

      Volume: 23 Issue: 11 Pages: 1382-1384

    • DOI

      10.1634/theoncologist.2018-0167

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Mucinous adenocarcinoma, gastric type of the uterine cervix: clinical features and HER2 amplification2018

    • Author(s)
      Nakamura Ayano、Yamaguchi Ken、Minamiguchi Sachiko、Murakami Ryusuke、Abiko Kaoru、Hamanishi Junzo、Kondoh Eiji、Baba Tsukasa、Mandai Masaki、Matsumura Noriomi
    • Journal Title

      Medical Molecular Morphology

      Volume: 52 Issue: 1 Pages: 52-59

    • DOI

      10.1007/s00795-018-0202-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Snail promotes ovarian cancer progression by recruiting myeloid-derived suppressor cells via CXCR2 ligand upregulation.2018

    • Author(s)
      Taki M, Abiko K, Baba T, Hamanishi J, Yamaguchi K, Murakami R, Yamanoi K, Horikawa N, Hosoe Y, Nakamura E, Sugiyama A, Mandai M, Konishi I, Matsumura N.
    • Journal Title

      Nature communications

      Volume: Apr 27;9(1) Issue: 1 Pages: 1685-1685

    • DOI

      10.1038/s41467-018-03966-7

    • NAID

      120006462510

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.2018

    • Author(s)
      Lin H, Wei S, Hurt EM, Green MD, Zhao L, Vatan L, Szeliga W, Herbst R, Harms PW, Fecher LA, Vats P, Chinnaiyan AM, Lao CD, Lawrence TS, Wicha M, Hamanishi J, Mandai M, Kryczek I, Zou W.
    • Journal Title

      J Clin Invest

      Volume: Apr 2;128(4) Issue: 4 Pages: 1708-1708

    • DOI

      10.1172/jci120803

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 婦人科がんの新たな治療 婦人科がんの新たな治療薬2018

    • Author(s)
      濵西 潤三
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 70 Pages: 2324-2332

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫チェックポイント阻害薬の治療効果予測のためのバイオマーカー2018

    • Author(s)
      濵西 潤三, 万代 昌紀
    • Journal Title

      がん分子標的治療

      Volume: 16 Pages: 297-302

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 婦人科腫瘍に対する免疫チェックポイント阻害薬2018

    • Author(s)
      濵西 潤三, 万代 昌紀
    • Journal Title

      腫瘍内科

      Volume: 22 Pages: 310-315

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 婦人科がんー研究・臨床の新展開 「上皮性卵巣癌・卵管癌・腹膜癌:分子生物学的背景と分子標的薬」2018

    • Author(s)
      濵西潤三、万代昌紀
    • Journal Title

      医学のあゆみ

      Volume: 266 Pages: 89-96

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 【難治性婦人科悪性腫瘍の臨床最前線】 外陰/腟悪性黒色腫2018

    • Author(s)
      濵西潤三、万代昌紀
    • Journal Title

      産婦人科の実際

      Volume: 67 Pages: 775-780

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 免疫チェックポイント阻害薬とは何か2018

    • Author(s)
      濵西潤三 万代昌紀
    • Journal Title

      臨床婦人科産科

      Volume: 72 Pages: 530-541

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 卵巣がん 卵巣癌の治療 免疫チェックポイント(PD-1)阻害薬2018

    • Author(s)
      濵西潤三 万代昌紀
    • Journal Title

      日本臨床

      Volume: 76 Pages: 669-675

    • Related Report
      2018 Annual Research Report
  • [Presentation] Immune checkpoint inhibition for Ovarian cancer2021

    • Author(s)
      Junzo Hamanishi.
    • Organizer
      JSMO 2021 Symposium
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] MSI-High 婦人科癌の治療最前線 ~実臨床におけるキイトルーダの Check Point~2021

    • Author(s)
      濵西 潤三
    • Organizer
      第62回日本婦人科腫瘍学会学術講演会 ランチョンセミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 婦人科癌における分子標的薬の躍進2020

    • Author(s)
      濵西 潤三
    • Organizer
      第45回日本外科系連合学会学術集会 シンポジウム講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 腫瘍免疫からみた生殖免疫2020

    • Author(s)
      濵西 潤三
    • Organizer
      第35回日本生殖免疫学会総会・学術集会 シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 「MSI-H 固形がんから学ぶ、婦人科腫瘍における免疫療法の現状と展望」2020

    • Author(s)
      濵西潤三
    • Organizer
      第19回日本婦人科がん分子標的研究会 ランチョンセミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 「Immuno Oncology 概論 ー理論と実践ー」2020

    • Author(s)
      濵西潤三
    • Organizer
      日本癌治療学会 第19回 アップデート教育コース がん治療とゲノム医療 教育講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Immune checkpoint inhibition for Gynecologic cancers Perspectives and Issues2019

    • Author(s)
      Junzo Hamanishi.
    • Organizer
      14th World Congress of the International Society for Immunology of Reproduction.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 臨床研究視点から考える免疫原性の重要性2019

    • Author(s)
      濵西 潤三
    • Organizer
      第23回 日本がん免疫学会 シンポジウム (日本バイオテラピー学会合同シンポジウム)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 本邦の婦人科悪性腫瘍に対するアンメットニーズと当科の取り組み2019

    • Author(s)
      濵西潤三
    • Organizer
      日本婦人科腫瘍学会 学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Recent Translational Research of Gynecologic Cancers2019

    • Author(s)
      Junzo Hamanishi
    • Organizer
      第17回日本臨床腫瘍学会学術集会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 生殖医学フォーラムの歴史2019

    • Author(s)
      濵西潤三
    • Organizer
      第24回 生殖医学フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 婦人科領域におけるMSI検査と導入事例2019

    • Author(s)
      濵西潤三
    • Organizer
      MSI-Highがんセミナー in 多摩
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生命のがん教育2019

    • Author(s)
      濵西 潤三
    • Organizer
      がん教育推進プロジェクト事業 京都教育委員会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 京大発、新しい婦人科がん治療開発への挑戦2019

    • Author(s)
      濵西潤三
    • Organizer
      京大病院地域連携の集い
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 当科における再発卵巣がんに対するオラパリブ使用経験から学ぶ今後の治療戦略2019

    • Author(s)
      濵西潤三
    • Organizer
      Ovarian Cancer Scientific Exchange Meeting in Kyoto
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 免疫チェックポイント阻害剤の特徴を理解する─ MSI-Highがんに対するペムブロリズマブの有効性を含めて ─2019

    • Author(s)
      濵西 潤三
    • Organizer
      Gynecologic Cancer Symposium
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 婦人科がんにおけるリンチ症候群と免疫チェックポイント阻害薬2019

    • Author(s)
      濵西 潤三
    • Organizer
      AMEDゲノム創薬基盤推進研究事業 リンチ症候群とMSI検査 がんゲノム医療中核病院事業
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 当科における再発卵巣がんに対する PARP阻害薬の使用経験から学ぶ 今後の治療戦略2019

    • Author(s)
      濵西 潤三
    • Organizer
      Scientific Exchange Meeting
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] MSI-Highがんを治療する上で 産婦人科の先生に知っておいてほしいこと2019

    • Author(s)
      濵西 潤三
    • Organizer
      Oncology インターネット講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Passenger fusion genes are novel predictive biomarker of anti-PD-1 antibody nivolumab for ovarian cancer2019

    • Author(s)
      Junzo Hamanishi, Ryusuke Murakami, John B Brown, Tsukasa Baba, Eiji Suzuki, Kaoru Abiko, Masaki Mandai
    • Organizer
      50th Annual Meeting on Women's Cancer (SGO 2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PD-1/PD-L1の臨床応用2019

    • Author(s)
      濵西潤三
    • Organizer
      関西実験動物研究会 第141回研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] VISTA expressed in tumor cells regulates T cell function VISTA expressed in tumor cells regulates T cell function2018

    • Author(s)
      Murat Kumuruz, 濱西 潤三, 松村 謙臣, 茶本 健司, 三瀬 名丹, 安彦 郁, 馬場 長, 山口 建, 村上 隆介, 細江 裕子, 東 みゆき, 小西 郁夫, 万代 昌紀
    • Organizer
      日本癌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 浮田 真沙世, 濱西 潤三, 村上 隆介, 安彦 郁, 馬場 長, 万代 昌紀2018

    • Author(s)
      卵巣癌に対するPD-1 dominant negative受容体発現CAR-T細胞療法の基礎的検討(Chimeric antigen receptor T(CAR-T) cell therapy with intrinsic PD-1 blocking for ovarian cancer)
    • Organizer
      日本癌学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 婦人科がんの診断・治療 婦人科がんにおける新たな診断・治療に向けて がん遺伝子パネル検査からがん免疫療法へ2018

    • Author(s)
      濵西 潤三
    • Organizer
      日本婦人科腫瘍学会 学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 生涯研修プログラム 婦人科がんの新たな治療薬2018

    • Author(s)
      濵西 潤三
    • Organizer
      第70回 日本産科婦人科学会 学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Passenger fusion genes are novel predictive biomarker of anti-PD-1 antibody nivolumab for ovarian cancer.2018

    • Author(s)
      Junzo Hamanishi, Ryusuke Murakami, John B Brown, Tsukasa Baba, Eiji Suzuki, Kaoru Abiko, Masaki Mandai
    • Organizer
      The 50th of American Association for Cancer Research (AACR 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] VISTA in tumor cells regulates T cell function2018

    • Author(s)
      Junzo Hamanishi, Kumuruz Murat, Kenji Chamoto, Nathan Mise, Kaoru Abiko, Tsukasa Baba, Ryusuke Murakami, Miyuki Azuma, Masaki Mandai
    • Organizer
      45th Naito Conference
    • Related Report
      2018 Annual Research Report
  • [Presentation] Immune checkpoint PD-1 inhibition for ovarian cancer2018

    • Author(s)
      Junzo Hamanishi
    • Organizer
      17th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2018), Symposium.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NEW PERSPECTIVES OF PD-1 INHIBITION FOR GYNECOLOGIC CANCER2018

    • Author(s)
      Junzo Hamanishi
    • Organizer
      17th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2018), Symposium.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Efficacy of Immuno-checkpoint Inhibitors in Ovarian Cancer2018

    • Author(s)
      Junzo Hamanishi
    • Organizer
      FIGO 2018. XXII World Congress of Gynecology and Obstetrics, Symposium.
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 婦人科腫瘍に対する 免疫チェックポイント阻害薬と CAR T細胞療法の現状と展望2018

    • Author(s)
      濵西 潤三
    • Organizer
      第3回 日本肉腫学会 学術講演会 学術シンポジウム
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 卵巣癌に対する新たな治療への 展望と課題2018

    • Author(s)
      濵西 潤三
    • Organizer
      アストラゼネカ社 講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] 婦人科腫瘍治療アップデート 「免疫チェックポイント阻害薬」 Page62-75 濵西潤三, 万代昌紀  分担2020

    • Author(s)
      岡本愛光: 濵西潤三, 万代昌紀 分担
    • Total Pages
      340
    • Publisher
      中外医学社
    • Related Report
      2020 Annual Research Report
  • [Book] よくわかるがん免疫療法ガイドブック2020

    • Author(s)
      日本バイオセラピィ学会「よくわかるがん免疫療法ガイドブック-患者さんとご家族のために-」作成ワーキンググループ、厚生労働科学研究費補助金(がん対策推進総合研究事業)「科学的根拠に基づいたがん免疫療法の評価とPublicity」班:濵西潤三, 万代昌紀 分担
    • Total Pages
      150
    • Publisher
      金原出版
    • ISBN
      9784307102049
    • Related Report
      2020 Annual Research Report
  • [Book] ゲノム医療時代のがん分子標的薬と診断薬研究 実験医学増刊 濵西潤三, 万代昌紀 分担2020

    • Author(s)
      濵西潤三, 万代昌紀 分担
    • Total Pages
      210
    • Publisher
      羊土社
    • ISBN
      9784758103893
    • Related Report
      2020 Annual Research Report
  • [Book] 各科スペシャリストが伝授 内科医が知っておくべき疾患1022020

    • Author(s)
      濵西潤三, 万代昌紀 分担
    • Total Pages
      224
    • Publisher
      中山書店
    • ISBN
      9784521748054
    • Related Report
      2020 Annual Research Report
  • [Book] がん免疫療法の個別化を支える新・腫瘍免疫学 【がん免疫療法の個別化を支える 新・腫瘍免疫学】 第II部 がん免疫療法の臨床開発における課題と対応 (第3章)免疫療法のリバーストランスレーショナル研究 婦人科がん(子宮体がん・子宮頸がん・卵巣がん)2019

    • Author(s)
      濱西潤三
    • Total Pages
      267
    • Publisher
      羊土社
    • ISBN
      9784758103817
    • Related Report
      2019 Annual Research Report
  • [Book] 実践 臨床生殖免疫学 PD-1/PD-L1経路阻害薬2018

    • Author(s)
      濵西潤三, 万代昌紀
    • Publisher
      中外医学社
    • Related Report
      2018 Annual Research Report
  • [Book] 婦人科腫瘍遺伝カウンセリングマニュアル 卵巣がんの治療(外科的治療・内科的治療) 免疫チェックポイント阻害薬2018

    • Author(s)
      濵西潤三, 万代昌紀
    • Publisher
      中外医学社
    • Related Report
      2018 Annual Research Report
  • [Book] 免疫治療の現在と未来 がん免疫療法2018

    • Author(s)
      濵西潤三
    • Publisher
      日本産科婦人科学会 研修ノート
    • Related Report
      2018 Annual Research Report
  • [Remarks] 京都大学 産婦人科 腫瘍研究室

    • URL

      https://www.kuhp.kyoto-u.ac.jp/~obgy/labo/labo_01.html

    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      https://www.jci.org/articles/view/96113

    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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