| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
|
|---|
| Outline of Final Research Achievements |
In vitro study using cultured human ASCs found that a single dose of irradiation resulted in a dose-dependent cytotoxicity, but only up to a 2-Gy dose, suggesting the cell cycle stage is critical for determination of susceptibility of stem cells to radiation. The animal study revealed that, in contrast to acute radiation injury, chronic radiation damage-associated wound healing capacity was not proportional to the individual dose or the total irradiation dose received, but appeared to be highly influenced by the number of and the interval between irradiations, if each dose was more than 2 Gy. After radiation exposure, the tissue functions, including vascularity and wound healing capacity, were impaired progressively over time. This result indicated that the tissue devitalization did not result directly from the acute injury; it resulted from the stem cell depletion that was a progressive consequence from repeated irradiation.
|
