Physiological substrates for masticatory rhythm generation during REM sleep

• Project/Area Number: 18H02965
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57010:Oral biological science-related
• Research Institution: Osaka University
• Principal Investigator: Kato Takafumi 大阪大学, 歯学研究科, 教授 (50367520)
• Co-Investigator(Kenkyū-buntansha): 豊田 博紀 大阪大学, 歯学研究科, 准教授 (00432451) ; 片桐 綾乃 大阪大学, 歯学研究科, 講師 (40731899) ; 佐藤 元 大阪大学, 歯学研究科, 助教 (10432452)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2019: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2018: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
• Keywords: 睡眠 / ブラキシズム / 咀嚼 / レム睡眠 / 咀嚼筋活動 / リズム / 脳波 / 睡眠時ブラキシズム / 顎運動 / 大脳皮質 / 中脳 / 咀嚼運動 / 脳幹 / 咀嚼リズム / リズム発生機構 / 異常運動 / 運動抑制

Outline of Final Research Achievements

Rhythmic jaw movements (RJMs) frequently occurred during sleep in sleep bruxism. However, the physiological mechanisms remains to be clarified. This study investigated the role of REM sleep processes in the genesis of RJMs in animals and humans. Cortically generated RJMs can be induced during REM sleep with the intense stimulus intensity. REM generator systems can inhibit the genesis of RJMs by the electrical stimulation to the midbrain. The sufficient amount of REM sleep genesis can be related to the RJMs while the arousal or transient stage shift can be important to generate RJMs during REM sleep. The results suggest that there might be a functional correlation between REM sleep genesis and masticatory motor activation.

Academic Significance and Societal Importance of the Research Achievements

睡眠中の歯ぎしりのように、眠っているときに咀嚼筋が繰り返し強く活動すると、歯の咬耗や顎関節症などの原因となる。しかし、睡眠中に歯ぎしりが発生するメカニズムは明らかではない。本研究では、睡眠を調節する機構と、咀嚼などの顎運動を制御する機構の関連を、実験動物とヒトのデータを用いて、レム睡眠を調節するしくみが咀嚼運動の変調に関係する可能性を明らかにした。この成果は、歯ぎしりの発生に関与する脳のしくみを解明する上で重要である。

Research Products

• [Journal Article] Motor representation of rhythmic jaw movements in the amygdala of guinea pigs (2022)
  • Author(s): Ueno Yoshio、Higashiyama Makoto、Haque Tahsinul、Masuda Yuji、Katagiri Ayano、Toyoda Hiroki、Uzawa Narikazu、Yoshida Atsushi、Kato Takafumi
  • Journal Title: Archives of Oral Biology Volume: 135 Pages: 105362-105362
  • DOI: 10.1016/j.archoralbio.2022.105362
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Enhanced Ocular Surface and Intraoral Nociception via a Transient Receptor Potential Vanilloid 1 Mechanism in a Rat Model of Obstructive Sleep Apnea (2022)
  • Author(s): Kishimoto Saki、Katagiri Ayano、Oyamaguchi Aiko、Sato Hajime、Toyoda Hiroki、Niwa Hitoshi、Bereiter David A.、Iwata Koichi、Kato Takafumi
  • Journal Title: Neuroscience Volume: 483 Pages: 66-81
  • DOI: 10.1016/j.neuroscience.2021.12.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sleep stage-dependent changes in tonic masseter and cortical activities in young subjects with primary sleep bruxism (2022)
  • Author(s): Toyota Risa、Fukui Ken-ichi、Kamimura Mayo、Katagiri Ayano、Sato Hajime、Toyoda Hiroki、Rompre Pierre、Ikebe Kazunori、Kato Takafumi
  • Journal Title: Sleep Volume: 45 Issue: 4
  • DOI: 10.1093/sleep/zsab207
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] After-effects of acute footshock stress on sleep states and rhythmic masticatory muscle activity during sleep in guinea pigs (2022)
  • Author(s): Yano Hiroyuki、Ueno Yoshio、Higashiyama Makoto、Akhter Fatema、Katagiri Ayano、Toyoda Hiroki、Uzawa Narikazu、Yoshida Atsushi、Kato Takafumi
  • Journal Title: Odontology Volume: - Issue: 3 Pages: 476-481
  • DOI: 10.1007/s10266-021-00679-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A lack of specific motor patterns between rhythmic/non-rhythmic masticatory muscle activity and bodily movements in sleep bruxism (2021)
  • Author(s): Imai Hideto、Haraki Shingo、Tsujisaka Akiko、Okura Mutsumi、Adachi Hiroyoshi、Ohno Yuko、Yatani Hirofumi、Kato Takafumi
  • Journal Title: Journal of Prosthodontic Research Volume: 65 Issue: 3 Pages: 415-420
  • DOI: 10.2186/jpr.JPR_D_20_00012
  • NAID: 130008076970
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Open Access
• [Journal Article] Discrepancies in the time course of sleep stage dynamics, electroencephalographic activity and heart rate variability over sleep cycles in the adaptation night in healthy young adults. (2021)
  • Author(s): Shirota, A., M. Kamimura, A. Kishi, H. Adachi, M. Taniike, T. Kato.
  • Journal Title: Frontiers in Physiology Volume: 12 Pages: 1-11
  • DOI: 10.3389/fphys.2021.623401
  • Peer Reviewed / Open Access
• [Journal Article] Research routes on improved sleep bruxism metrics: Toward a standardised approach (2021)
  • Author(s): Lavigne Gilles、Kato Takafumi、Herrero Babiloni Alberto、Huynh Nelly、Dal Fabbro Cibele、Svensson Peter、Aarab Ghizlane、Ahlberg Jari、Baba Kazuyoshi、Carra Maria Clotilde、Cunha Thays Crosara A.、Gon?alves Daniela A. G.、Manfredini Daniele、Stuginski‐Barbosa Juliana、Wieckiewicz Mieszko、Lobbezoo Frank
  • Journal Title: Journal of Sleep Research Volume: - Issue: 5
  • DOI: 10.1111/jsr.13320
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] First night effect on polysomnographic sleep bruxism diagnosis varies among young subjects with different degrees of rhythmic masticatory muscle activity (2020)
  • Author(s): Haraki Shingo、Tsujisaka Akiko、Toyota Risa、Shiraishi Yuki、Adachi Hiroyoshi、Ishigaki Shoichi、Yatani Hirofumi、Taniike Masako、Kato Takafumi
  • Journal Title: Sleep Medicine Volume: 75 Pages: 395-400
  • DOI: 10.1016/j.sleep.2020.08.012
  • Peer Reviewed
• [Journal Article] Sleep stage dynamics in young patients with sleep bruxism (2020)
  • Author(s): Kishi Akifumi、Haraki Shingo、Toyota Risa、Shiraishi Yuki、Kamimura Mayo、Taniike Masako、Yatani Hirofumi、Kato Takafumi
  • Journal Title: Sleep Volume: 43 Issue: 1 Pages: 1-12
  • DOI: 10.1093/sleep/zsz202
  • Peer Reviewed / Open Access
• [Journal Article] Experimentally induced rhythmic jaw muscle activities during non-rapid eye movement sleep in freely moving guinea pigs. (2019)
  • Author(s): Yamada KI, Higashiyama M, Toyoda H, Masuda Y, Kogo M, Yoshida A, Kato T
  • Journal Title: Journal of Sleep Research Volume: e12823 Issue: 5
  • DOI: 10.1111/jsr.12823
  • Peer Reviewed
• [Journal Article] Changes in oxygen and carbon dioxide in the genesis of sleep bruxism: a mechanism study (2019)
  • Author(s): Suzuki Y, Rompre P, Mayer P, Kato T, Okura K, Lavigne GJ
  • Journal Title: Journal of Prosthodontic Research Volume: 64 Issue: 1 Pages: 43-47
  • DOI: 10.1016/j.jpor.2019.04.012
  • NAID: 130007845589
  • ISSN: 1883-1958, 1883-9207
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Pathophysiology of SB: lessens from human for future animal studies (2021)
  • Author(s): Takafumi Kato
  • Organizer: Society for Neuroscience 2021 6th Satellite Symposium
  • Int'l Joint Research / Invited
• [Presentation] モルモット扁桃体における短潜時顎筋応答誘発部位の局在 (2021)
  • Author(s): 上野祥夫、吉田篤、鵜澤成一、加藤隆史
  • Organizer: 第75回日本口腔科学会学術集会
• [Presentation] Gastroesophageal reflux and obstructive sleep apnea (2021)
  • Author(s): Takafumi Kato
  • Organizer: 99th general session of the International Association for Dental Research
  • Int'l Joint Research / Invited
• [Presentation] Pathophysiology of SB: challenges from human and animal studies. (2020)
  • Author(s): Kato T.
  • Organizer: The 68th Annual Meeting of Japanese Association for Dental Research
  • Int'l Joint Research / Invited
• [Presentation] Masseter Muscle Activity During REM Sleep in Sleep Bruxism (2019)
  • Author(s): R.Toyota, M.Okura, S.Haraki, A.Tsujisaka, H.Adachi, K.Ikebe, H.Yatani, T.Kato
  • Organizer: 97th.IADR General Session
  • Int'l Joint Research
• [Presentation] Sleep Bruxism：An Update for dental Clinicians (2019)
  • Author(s): Takafumi Kato
  • Organizer: ADA FDI World Dental Congress 2019
  • Int'l Joint Research / Invited
• [Presentation] Sleep Related Problems in Dentistry (2019)
  • Author(s): Takafumi Kato
  • Organizer: ADA FDI World Dental Congress 2019
  • Int'l Joint Research / Invited
• [Presentation] 睡眠時ブラキシズムの謎を解くために (2019)
  • Author(s): 加藤隆史
  • Organizer: 第88回松本歯科大学学会（総会）
  • Invited
• [Presentation] The feature of sleep stage sequence of nocturnal REM periods reflects the pathophysiology of narcolepsy (2019)
  • Author(s): Mashita M, Adachi H, Koyama M, Nonoue S, Mamiya Y, Shigedo Y, Sugita Y, Kyotani K, Kato T, Ikeda M.
  • Organizer: Worldsleep 2019
  • Int'l Joint Research
• [Presentation] Sleep stage dynamics in patients with sleep bruxism (2018)
  • Author(s): Kishi A, Kato T.
  • Organizer: The 32nd Annual Meeting of the Associated Professional Sleep Societies, Baltimore, MD, USA, June 3-6
  • Int'l Joint Research
• [Presentation] Masseter muscle activity during REM sleep in young adults with sleep bruxism (2018)
  • Author(s): Risa Toyota, Mutsumi Okura, Shigeru Nonoue, Shingo Haraki, Akiko Tsujisaka, Hiroyoshi Adachi, Kazunori Ikebe, Takafumi Kato.
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Physiological characteristics of rhythmic masticatory muscle activity during sleep in children (2018)
  • Author(s): Yuki Shiraishi, Masaya Tachibana, Sheng-Yun Lu, Ai Shirota, Ikuko Mohri, Shingo Haraki, Atsuko Tsujisaka, Masako Taniike, Takashi Yamashiro, Takafumi Kato.
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Physiologic process before rhythmic jaw movements after ketamine injections in guinea pigs. (2018)
  • Author(s): Takafumi Kato, Yutaka Matsuura, Hiroshi Yano, Makoto Higashiyama, Hiroki Toyoda, Ayano Katagiri, Hajime Sato, Narikazu Uzawa, Atsushi Yoshida.
  • Organizer: 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] ケタミン麻酔動物におけるリズム性顎運動発現の生理学的機序 (2018)
  • Author(s): 松裏豊，矢野浩司，豊田博紀，片桐綾乃，東山亮，鵜澤成一，吉田篤，加藤隆史.
  • Organizer: 第60回歯科基礎医学会学術大会
• [Presentation] Time-course changes in cortical, cardiac and respiratory changes before spontaneous rhythmic jaw movements after repeated ketamine injections in anesthetized guinea pigs. (2018)
  • Author(s): Yutaka Matsuura, Hiroshi Yano, Hiroki Toyoda, Ayano Katagiri, Makoto Higashiyama, Hajime Sato, Narikazu Uzawa, Atsushi Yoshida, Takafumi Kato.
  • Organizer: Oral Neuroscience 2018
  • Int'l Joint Research
• [Book] 最新臨床睡眠学(第2版） (2020)
  • Author(s): 加藤隆史、豊田理紗、白石優季、原木真吾
  • Total Pages: 765
  • Publisher: 日本臨牀社
• [Book] Sleep Medicine For Dentists 2nd eds, Physiologic mechanisms associated with SB genesis (2020)
  • Author(s): Kato T, Okura K, Macaluso GM, Lavigne GJ
  • Total Pages: 224
  • Publisher: Quintessence publishing
• [Book] 基礎歯科生理学第7版 第12章 高次脳機能 IV 睡眠 (2020)
  • Author(s): 加藤隆史
  • Total Pages: 475
  • Publisher: 医歯薬出版株式会社