Clarification of novel tissue destruction mechanism induced by mechanobiology breakdown
| Project/Area Number |
18H02975
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 57030:Conservative dentistry-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉田 恭子 (今中恭子) 三重大学, 医学系研究科, 教授 (00242967)
山田 聡 東北大学, 歯学研究科, 教授 (40359849)
半田 慶介 神奈川歯科大学, 大学院歯学研究科, 教授 (40433429)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 細胞外マトリックス / 結合組織 / 炎症 / 弾性線維 / 細胞害マトリックス / メカノバイオロジー / 免疫機構 / 組織破壊 / 抗炎症療法 / 結合組織疾患 / 機械的外力 / 抗炎症 / 歯周組織 |
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| Outline of Final Research Achievements |
In order to investigate the effect of mechanical force on the development of connective tissue disease, we generated ADAMTSL6-deficient mice, which are polymerization regulators of elastic fibers that play a critical for regulating tissue strength. ADAMTSL6 is an extracellular matrix that promotes the polymerization of fibrillin-1microfibril, which is essential to elastic fiber formation. ADAMTSL6 has two types, alpha and beta, and that alpha knockout mice is embryonic lethality and beta knockout mice able to survive. An apical periodontitis model was performed to investigate if ADAMTSL6 beta knockout mice the effects of connective tissue disease. Result indicated that ADAMTSL6 beta knockout mice clearly induced bone destruction in this model. From these result, reduction of elastic fibers strength may cause connective tissue disease.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は機械的外力が病気の発症に係るかを調べた研究である。機械的外力の低下で発症する病気の代表例で解離性大動脈瘤が知られているが、歯科領域でも歯周病、根尖性歯周炎などの炎症性疾患の原因になりことが報告されてきた。しかし機械的外力がどのように体内で調整され、病気に関わるかは全く不明であった。本研究では人為的に機械的強度を弱めた実験モデルを用いて顎骨破壊が促進することを証明した。これらの成果により機械的強度の維持を目指した治療が病気予防に重要な働きをすることが示された。
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo,2019
Author(s)
V. VENKATA Suresh, Keisuke HANDA, Mary M. NJUGUNA, Tatsuya HASEGAWA, Kentaro MARUYAMA, Eiji NEMOTO, Satoru YAMADA, Shunji SUGAWARA, Lu LU, Masahide TAKEDACHI, Shinya MURAKAMI, Hanayuki OKURA, Akifumi MATSUYAMA and Masahiro SAITO
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Journal Title
Sci Rep.
Volume: 29;9(1)
Issue: 1
Pages: 921-921
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 歯科再生医学2019
Author(s)
村上伸也・網塚憲生・齋藤正寛・松本卓也
Total Pages
334
Publisher
医歯薬出版
ISBN
9784263458389
Related Report
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