Establishing Evidence for Extending Healthy Life Span by Maintaining Oral Function: A 9-year Cohort Study of 2,600 People

• Project/Area Number: 18H02990
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57050:Prosthodontics-related
• Research Institution: Osaka University
• Principal Investigator: Ikebe Kazunori 大阪大学, 大学院歯学研究科, 教授 (70273696)
• Co-Investigator(Kenkyū-buntansha): 増井 幸恵 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (10415507) ; 松田 謙一 大阪大学, 大学院歯学研究科, 招へい教員 (80448109) ; 小川 泰治 大阪大学, 歯学研究科, 招へい教員 (10543481)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000); Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2018: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 口腔機能 / 高齢者 / 健康長寿 / 認知機能 / 運動機能 / 健康寿命 / 咬合力 / サルコペニア

Outline of Final Research Achievements

We examined the association between oral function and sarcopenia in community-dwelling older adults and found that occlusal strength was associated with the incidence of sarcopenia. In addition, a longitudinal study of the association between molar occlusal support and decreased walking speed using propensity score matching showed that loss of molar occlusal support at baseline predicted the occurrence of decreased walking speed over a 3-year period. Furthermore, a longitudinal analysis was conducted to examine the effects of gender, age, aging, and number of teeth on occlusal force and tongue pressure. The results indicated that occlusal force was less affected by aging, while tongue pressure was more affected by aging.

Academic Significance and Societal Importance of the Research Achievements

本研究により、咬合力がサルコペニアと関連することが明らかとなった。さらに、縦断的な分析により、臼歯部咬合支持を維持することが歩行速度の低下を予防しうることが明らかとなった。一方、咬合力は舌圧とは異なり、加齢による影響が少なく、性別や残存歯数と関連することが明らかとなった。すなわち、年を重ねたからといって咬合力が低下していくわけではなく、自身によるプラークコントロールを徹底することに加え、早期かつ継続的な歯科治療によって残存歯数を維持することができれば、咬合力を維持することができ、歩行速度低下やサルコペニアの予防につながると考えられる。

Research Products

• [Journal Article] Factors Related to Preventive Behaviors against a Decline in Physical Fitness among Community-Dwelling Older Adults during the COVID-19 Pandemic: A Qualitative Study. (2022)
  • Author(s): Kimura Y, Akasaka H, Takahashi T, Yasumoto S, Kamide K, Ikebe K, Kabayama M, Kasuga A, Rakugi H, Gondo Y
  • Journal Title: Int J Environ Res Public Health Volume: 19 Issue: 10 Pages: 6008-6008
  • DOI: 10.3390/ijerph19106008
  • Peer Reviewed / Open Access
• [Journal Article] Older Adults' Resilience Against Impact of Lifestyle Changes During the COVID-19 Pandemic. (2022)
  • Author(s): Kasuga A, Yasumoto S, Nakagawa T, Ishioka Y, Kikuchi A, Inagaki H, Ogawa M, Hori N, Masui Y, Choe H, Muto H, Kabayama M, Godai K, Ikebe K, Kamide K, Ishizaki T, Gondo Y.
  • Journal Title: Gerontol Geriatr Med. Volume: 8 Pages: 233-233
  • DOI: 10.1177/23337214221116226
  • Peer Reviewed / Open Access
• [Journal Article] Lack of posterior occlusal support predicts the reduction in walking speed in 80‐year‐old Japanese adults: A 3‐year prospective cohort study with propensity score analysis by the SONIC Study Group (2019)
  • Author(s): Hatta Kodai、Ikebe Kazunori、Mihara Yusuke、Gondo Yasuyuki、Kamide Kei、Masui Yukie、Sugimoto Ken、Matsuda Ken‐ichi、Fukutake Motoyoshi、Kabayama Mai、Shintani Ayumi、Ishizaki Tatsuro、 Arai Yasumichi、Rakugi Hiromi、Maeda Yoshinobu
  • Journal Title: Gerodontology Volume: - Issue: 2 Pages: 156-162
  • DOI: 10.1111/ger.12393
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hyperglycemia in non-obese patients with type 2 diabetes is associated with low muscle mass: The MUSCLES-DM study. (2019)
  • Author(s): Sugimoto K, Tabara Y, Ikegami H, Takata Y, Kamide K, Ikezoe T, Kiyoshige E, Makutani Y, Onuma H, Gondo Y, Ikebe K, Ichihashi N, Tsuboyama T, Matsuda F, Kohara K, Kabayama M, Fukuda M, Katsuya T, Osawa H, Hiromine Y, Rakugi H.
  • Journal Title: J Diabetes Investig. Volume: 10: Issue: 6 Pages: 1471-1479
  • DOI: 10.1111/jdi.13070
  • Peer Reviewed / Open Access
• [Journal Article] Influence of lack of posterior occlusal support on cognitive decline among 80-year-old Japanese pople in a 3-year prospective study (2018)
  • Author(s): Hatta K、Ikebe K、Gondo Y、Kamide K、Masui Y、Inagaki H、Nakagawa T、Matsuda K、Ogawa T、 Inomata C、Takeshita H、Mihara Y、Fukutake M、Kitamura M、Murakami S、Kabayama M、Ishizaki T、 Arai Y、Sugimoto K、Rakugi H、Maeda Y
  • Journal Title: Geriatrics & Gerontology International Volume: 18 Issue: 10 Pages: 1439-1446
  • DOI: 10.1111/ggi.13508
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between gerotranscendence and oral health-related quality of life (2018)
  • Author(s): Mihara Yusuke、Matsuda Ken-ichi、Hatta Koudai、Gondo Yasuyuki、Masui Yukie、Nakagawa Takeshi、 Kamide Kei、Ishizaki Tatsuro、Arai Yasumichi、Maeda Yoshinobu、Ikebe Kazunori
  • Journal Title: Journal of Oral Rehabilitation Volume: 45 Issue: 10 Pages: 805-809
  • DOI: 10.1111/joor.12691
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 地域在住高齢者における口腔機能と握力との関連─構造方程式モデリングを用いた検討─ (2022)
  • Author(s): 明間すずな，豆野智昭，八田昂大，高橋利士，和田誠大，室谷有紀，辻岡義祟，権藤恭之 ，神出計，樺山舞，杉本研，楽木宏実，石崎達郎，増井幸恵，池邉一典
  • Organizer: 日本サルコペニアフレイル学会第9回学術大会
• [Presentation] 超高齢者の口腔健康と幸福感との関連の検討 (2022)
  • Author(s): 能勢 彩花、八田 昂大、高橋 利士、豆野 智昭、福武 元良、西村 優一、室谷 有紀、萩野 弘将、 辻岡 義崇、明間 すずな、三原 佑介、和田 誠大、前田 芳信、池邉 一典
  • Organizer: 第33回日本老年歯科医学会学術大会
• [Presentation] Influence of occlusal force on decline in BMI among elders (2019)
  • Author(s): Fukutake M, Hatta K, Sato H, Mihara Y, Takeshita H, Enoki K, Matsuda K, Gondo Y, Kamide K, Arai Y, Ishizaki T, Masui Y, Maeda Y, Ikebe K
  • Organizer: I.A.D.R. General Session
  • Int'l Joint Research
• [Presentation] Occlusal Force Predict Decline in Cognitive Function in 3-Year (2019)
  • Author(s): Hatta K, Fukutake M, Sato H, Mihara Y, Hagino H, Enoki K, Murotani Y, Matsuda K, Maeda Y, Ikebe K
  • Organizer: International College of Prosthodontists
  • Int'l Joint Research
• [Presentation] Associations between sarcopenia and oral functions in old-old Japnese (2019)
  • Author(s): Murotani Y, Ikebe K
  • Organizer: International Association for Dental Research Asia-Pacific Region
  • Int'l Joint Research
• [Presentation] Occlusal contacts predict decline in cognitive function in 3-years (2018)
  • Author(s): Hatta K, Fukutake M, Sato H, Mihara Y, Matsuda K, Gondo Y, Kamide K, Masui Y, Ishizaki T, Arai Y, Sugimoto K, Inomata C, Takeshita H, Enoki K, Maeda Y, Ikebe K
  • Organizer: IADR
  • Int'l Joint Research
• [Presentation] Influence of occlusal force on malnutrition in older adults (2018)
  • Author(s): Fukutake M, Hatta K, Sato H, Mihara Y, Inomata C, Takeshita H, Enoki K, Matsuda K, Gondo Y, Kamide K, Arai Y, Ishizaki T, Masui Y, Maeda Y, Ikebe K
  • Organizer: IADR
  • Int'l Joint Research
• [Presentation] Influence of Mastication on Memory/Cognition During Development and Aging (2018)
  • Author(s): Ikebe K
  • Organizer: IADR
  • Int'l Joint Research / Invited