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Elucidation of stem cell signal using genome structure as an index and application to bone regenerative medicine

Research Project

Project/Area Number 18H02998
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57060:Surgical dentistry-related
Research InstitutionThe University of Tokyo

Principal Investigator

Hoshi Kazuto  東京大学, 医学部附属病院, 教授 (30344451)

Co-Investigator(Kenkyū-buntansha) 大庭 伸介  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (20466733)
疋田 温彦  東京大学, 医学部附属病院, 特任研究員 (60443397)
金澤 三四朗  東京大学, 医学部附属病院, 特任研究員 (60823466)
北條 宏徳  東京大学, 大学院医学系研究科(医学部), 准教授 (80788422)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2019: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords骨髄 / 多能性前駆細胞 / 幹細胞niche / single cell RNA-seq / RNA-seq / ATAC-seq / 骨髄間葉系幹細胞 / 造血-間葉相互作用 / GREAT解析 / エピゲノム解析 / open chromatin analysis / 幹細胞ニッシ
Outline of Final Research Achievements

One of the important cell lines derived from bone marrow is the MSC. In recent years, markers of MSC isolation have been reported, but they are still heterogeneous cell populations. Therefore, it is difficult to accurately evaluate the MSC characteristics. In this study, scRNA-seq analysis was used to identify seven genetically distinct subpopulations of mouse bone marrow MSCs. ATAC-seq analysis also revealed epigenetic landscapes, genetic similarities and functional characteristics. These results elucidate stem cell niche signals in the bone marrow microenvironment, reconstitute bone marrow in vitro, and are potentially important for subpopulations identified in various clinical applications in the treatment of bone and bone marrow-related disorders. It made it possible to shed light on the role.

Academic Significance and Societal Importance of the Research Achievements

本研究では、骨髄MSCのscRNA-seqにより、MSCには分化状態に多様性を示す7つの異なる亜集団で構成されていることを明らかにした。また、各集団は特徴的な分化指向性と機能的特徴を有することを示唆した。また、分離した亜集団のbulk RNA-seqおよびATAC-seq解析により、MSCを構成する亜集団の多様性を特徴づけた。
これらの結果は、MSCの本質的な特性の解明に寄与し、骨髄微小環境における幹細胞ニッチシグナルの解明と新たなin vitro培養法につながると期待される。また、骨および骨髄関連疾患の治療等さまざまな臨床応用への有用性を示唆する。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (52 results)

All 2021 2020 2019 2018

All Journal Article (36 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 36 results,  Open Access: 20 results) Presentation (14 results) (of which Int'l Joint Research: 7 results,  Invited: 10 results) Book (2 results)

  • [Journal Article] ChIP-Seq Assays from Mammalian Cartilage and Chondrocytes.2021

    • Author(s)
      Hojo H, Ohba S et al.
    • Journal Title

      Methods Mol Biol

      Volume: 2245 Pages: 167-178

    • DOI

      10.1007/978-1-0716-1119-7_12

    • ISBN
      9781071611180, 9781071611197
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Progress of Stem Cell Technology for Skeletal Regeneration2021

    • Author(s)
      Tani Shoichiro、Okada Hiroyuki、Chung Ung-il、Ohba Shinsuke、Hojo Hironori
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 3 Pages: 1404-1404

    • DOI

      10.3390/ijms22031404

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a new technique for the fabrication of regenerative cartilage with a microslicer device to prepare three dimensional diced cartilage2020

    • Author(s)
      Hikita A, Hoshi K et al.
    • Journal Title

      Biomedical Research

      Volume: 41 Issue: 2 Pages: 67-80

    • DOI

      10.2220/biomedres.41.67

    • NAID

      130007833268

    • ISSN
      0388-6107, 1880-313X
    • Year and Date
      2020-04-01
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ear Cartilage Reconstruction Combining Induced Pluripotent Stem Cell-Derived Cartilage and Three-Dimensional Shape-Memory Scaffold2020

    • Author(s)
      Uto Sakura、Hikita Atsuhiko、Sakamoto Tomoaki、Mori Daisuke、Yano Fumiko、Ohba Shinsuke、Saito Taku、Takato Tsuyoshi、Hoshi Kazuto
    • Journal Title

      Tissue Engineering Part A

      Volume: - Issue: 9-10 Pages: 604-617

    • DOI

      10.1089/ten.tea.2020.0106

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlling gene activation by enhancers through a drug-inducible topological insulator.2020

    • Author(s)
      Hoshi K et al.
    • Journal Title

      Elife

      Volume: 9

    • DOI

      10.7554/elife.47980

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of Damage-Associated Molecular Patterns from Chondrocytes in Tissue-Engineered Cartilage2020

    • Author(s)
      Fujihara Yuko、Abe Takahiro、Asawa Yukiyo、Nishizawa Satoru、Saijo Hideto、Hikita Atsuhiko、Hoshi Kazuto
    • Journal Title

      Tissue Engineering Part A

      Volume: 00 Issue: 1-2 Pages: 1-9

    • DOI

      10.1089/ten.tea.2019.0185

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Controlling the Phenotype of Macrophages Promotes Maturation of Tissue-Engineered Cartilage.2020

    • Author(s)
      Fujihara Y, Abe T, Hoshi K.
    • Journal Title

      Tissue Eng Part A.

      Volume: in press Issue: 17-18 Pages: 1005-1013

    • DOI

      10.1089/ten.tea.2019.0190

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Saponin facilitates anti-Robo1 immunotoxin cytotoxic effects on maxillary sinus squamous cell carcinoma.2020

    • Author(s)
      Noriko Komatsu, Miku Komatsu, Riuko Ohashi, Akira Horii, Kazuto Hoshi, Tsuyoshi Takato, Takahiro Abe, Takao Hamakubo
    • Journal Title

      Journal of Oncology

      Volume: - Pages: 9593516-9593516

    • DOI

      10.1155/2020/9593516

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Awareness of Malocclusion Is Closely Associated with Allergic Rhinitis, Asthma, and Arrhythmia in Late Adolescents.2020

    • Author(s)
      Abe M, Mitani A, Yao A, Zong L, Hoshi K, Yanagimoto S.
    • Journal Title

      Healthcare

      Volume: 8 Issue: 3 Pages: 209-209

    • DOI

      10.3390/healthcare8030209

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photosensitizer with Illumination Enhances In Vivo Antitumor Effect of Anti-ROBO1 Immunotoxin on Maxillary Sinus Squamous Cell Carcinoma.2020

    • Author(s)
      3.Komatsu N, Komatsu M, Ohashi R, Horii A, Hoshi K, Takato T, Abe T, Hamakubo T.
    • Journal Title

      Anticancer Research

      Volume: 40(7) Issue: 7 Pages: 3793-3799

    • DOI

      10.21873/anticanres.14368

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimization of culture duration of bone marrow cells before transplantation with a β-tricalcium phosphate/recombinant collagen peptide hybrid scaffold.2020

    • Author(s)
      Kanazawa S et al.
    • Journal Title

      Regen Ther

      Volume: 14 Pages: 284-295

    • DOI

      10.1016/j.reth.2020.04.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Close Association between Awareness of Teeth-Alignment Disorder and Systemic Disorders in Late Adolescence.2020

    • Author(s)
      Hoshi K et al.
    • Journal Title

      Healthcare (Basel)

      Volume: 9(4) Issue: 4 Pages: 370-370

    • DOI

      10.3390/healthcare9040370

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel operative technique of advancement urethral meatoplasty utilizing buccal mucosa for Vulvar Paget's disease with urethral invasion: two case reports.2020

    • Author(s)
      Hoshi K et al.
    • Journal Title

      J Med Case Rep

      Volume: 15(1) Issue: 1 Pages: 136-136

    • DOI

      10.1186/s13256-021-02729-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Understanding paraxial mesoderm development and sclerotome specification for skeletal repair2020

    • Author(s)
      Tani Shoichiro、Chung Ung-il、Ohba Shinsuke、Hojo Hironori
    • Journal Title

      Experimental & Molecular Medicine

      Volume: 52 Issue: 8 Pages: 1166-1177

    • DOI

      10.1038/s12276-020-0482-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene regulatory landscape in osteoblast differentiation.2020

    • Author(s)
      Hojo H, Ohba S.
    • Journal Title

      Bone

      Volume: Epub 2020 Pages: 115458-115458

    • NAID

      120006988169

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The usefulness of the decellularized matrix from three-dimensional regenerative cartilage as a scaffold material.2020

    • Author(s)
      Hikita A et al.
    • Journal Title

      Regen Ther

      Volume: 15 Pages: 312-322

    • DOI

      10.1016/j.reth.2020.11.005

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hedgehog Activation Regulates Human Osteoblastogenesis2020

    • Author(s)
      Onodera Shoko、Saito Akiko、Hojo Hironori、Nakamura Takashi、Zujur Denise、Watanabe Katsuhito、Morita Nana、Hasegawa Daigo、Masaki Hideki、Nakauchi Hiromitsu、Nomura Takeshi、Shibahara Takahiko、Yamaguchi Akira、Chung Ung-il、Azuma Toshifumi、Ohba Shinsuke
    • Journal Title

      Stem Cell Reports

      Volume: 15 Issue: 1 Pages: 125-139

    • DOI

      10.1016/j.stemcr.2020.05.008

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphoglycerate Mutase 1 Activates DNA Damage Repair via Regulation of WIP1 Activity2020

    • Author(s)
      Ohba Shigeo、Johannessen Tor-Christian Aase、Chatla Kamalakar、Yang Xiaodong、Pieper Russell O.、Mukherjee Joydeep
    • Journal Title

      Cell Reports

      Volume: 31 Issue: 2 Pages: 107518-107518

    • DOI

      10.1016/j.celrep.2020.03.082

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action.2020

    • Author(s)
      Ohba S.
    • Journal Title

      Int J Mol Sci

      Volume: 21(18) Issue: 18 Pages: 6665-6665

    • DOI

      10.3390/ijms21186665

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glial Fibrillary Acidic Protein as Biomarker Indicates Purity and Property of Auricular Chondrocytes2020

    • Author(s)
      Nishizawa Satoru、Kanazawa Sanshiro、Fujihara Yuko、Asawa Yukiyo、Nagata Satoru、Harai Motohiro、Hikita Atsuhiko、Takato Tsuyoshi、Hoshi Kazuto
    • Journal Title

      BioResearch Open Access

      Volume: 9 Issue: 1 Pages: 51-63

    • DOI

      10.1089/biores.2019.0058

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adipose-derived stem cells improve tendon repair and prevent ectopic ossification in tendinopathy by inhibiting inflammation and inducing neovascularization in the early stage of tendon healing2020

    • Author(s)
      Kokubu Saeko、Inaki Ryoko、Hoshi Kazuto、Hikita Atsuhiko
    • Journal Title

      Regenerative Therapy

      Volume: 14 Pages: 103-110

    • DOI

      10.1016/j.reth.2019.12.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers2020

    • Author(s)
      Zujur Denise、Kanke Kosuke、Onodera Shoko、Tani Shoichiro、Lai Jenny、Azuma Toshifumi、Xin Xiaonan、Lichtler Alexander C.、Rowe David W.、Saito Taku、Tanaka Sakae、Masaki Hideki、Nakauchi Hiromitsu、Chung Ung-il、Hojo Hironori、Ohba Shinsuke
    • Journal Title

      Regenerative Therapy

      Volume: 14 Pages: 19-31

    • DOI

      10.1016/j.reth.2019.12.010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Proliferation medium in three-dimensional culture of auricular chondrocytes promotes effective cartilage regeneration in?vivo2019

    • Author(s)
      Okubo Ryuji、Asawa Yukiyo、Watanabe Makoto、Nagata Satoru、Nio Masaki、Takato Tsuyoshi、Hikita Atsuhiko、Hoshi Kazuto
    • Journal Title

      Regenerative Therapy

      Volume: 11 Pages: 306-315

    • DOI

      10.1016/j.reth.2019.10.002

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The period circadian clock 2 gene responds to glucocorticoids and regulates osteogenic capacity.2019

    • Author(s)
      Abe T, Sato T, Yoda T, Hoshi K.
    • Journal Title

      Regen Ther

      Volume: 11 Pages: 199-206

    • DOI

      10.1016/j.reth.2019.07.006

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of an anatomy-mimicking BIO-AIR-TUBE with engineered cartilage2019

    • Author(s)
      Hoshi K et al.
    • Journal Title

      Regenerative Therapy

      Volume: 11 Pages: 176-181

    • DOI

      10.1016/j.reth.2019.07.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insights into Gene Regulatory Networks in Chondrocytes2019

    • Author(s)
      Hojo Hironori、Ohba Shinsuke
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 24 Pages: 6324-6324

    • DOI

      10.3390/ijms20246324

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone2019

    • Author(s)
      Xuan Fengjun、Yano Fumiko、Mori Daisuke、Chijimatsu Ryota、Maenohara Yuji、Nakamoto Hideki、Mori Yoshifumi、Makii Yuma、Oichi Takeshi、Taketo Makoto Mark、Hojo Hironori、Ohba Shinsuke、Chung Ung-il、Tanaka Sakae、Saito Taku
    • Journal Title

      Arthritis Research & Therapy

      Volume: 21 Issue: 1 Pages: 247-247

    • DOI

      10.1186/s13075-019-2041-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds2019

    • Author(s)
      Kawata Manabu、Mori Daisuke、Kanke Kosuke、Hojo Hironori、Ohba Shinsuke、Chung Ung-il、Yano Fumiko、Masaki Hideki、Otsu Makoto、Nakauchi Hiromitsu、Tanaka Sakae、Saito Taku
    • Journal Title

      Stem Cell Reports

      Volume: 13 Issue: 3 Pages: 530-544

    • DOI

      10.1016/j.stemcr.2019.07.012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: A rare case report and literature review2019

    • Author(s)
      Abe M, Watanabe K, Shinozaki-Ushiku A, Ushiku T, Abe T, Fujihara Y, Amano Y, Zong L, Wang CP, Kubo E, Inaki R, Kinoshita N, Yamashi S, Takai D, Ushijima T, Nagase T, Hoshi K
    • Journal Title

      BMC Cancer

      Volume: 19(1) Issue: 1 Pages: 52-52

    • DOI

      10.1186/s12885-019-5277-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A case of arthritis of the temporomandibular joint with adult-onset Still's disease2018

    • Author(s)
      柏木 美樹、安部 貴大、藤原 夕子、小笠原 徹、西條 英人、星 和人
    • Journal Title

      Journal of the Japanese Society for the Temporomandibular Joint

      Volume: 30 Issue: 2 Pages: 202-207

    • DOI

      10.11246/gakukansetsu.30.202

    • ISSN
      0915-3004, 1884-4308
    • Year and Date
      2018-08-20
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biological aspects of tissue-engineered cartilage2018

    • Author(s)
      Hoshi K, Fujihara Y, Yamawaki T, Harai M, Asawa Y, Hikita A
    • Journal Title

      Histochem Cell Biol

      Volume: 149(4) Issue: 4 Pages: 375-381

    • DOI

      10.1007/s00418-018-1652-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical Findings of a Cantilever Iliac Bone Graft for Secondary Correction of Cleft Lip-Nose Deformities2018

    • Author(s)
      Sugiyama M, Nakatsuka T, Saijo H, Fujihara Y, Kanno Y, Hikita A, Takato T, Hoshi K
    • Journal Title

      J Craniofac Surg

      Volume: 掲載確定 Issue: 3 Pages: 741-746

    • DOI

      10.1097/scs.0000000000004070

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periostin contributes to the maturation and shape retention of tissue-engineered cartilage2018

    • Author(s)
      Inaki R, Fujihara Y, Kudo A, Misawa M, Hikita A, Takato T, Hoshi K
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 11210-11210

    • DOI

      10.1038/s41598-018-29228-6

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of cleft lip and palate associated with unilateral choanal atresia2018

    • Author(s)
      Fujihara Yuko、Kikuta Shu、Sugiyama Madoka、Kubota Keigo、Ishibashi Makiko、Igarashi Masaki、Saijo Hideto、Hoshi Kazuto
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 30 Issue: 6 Pages: 538-541

    • DOI

      10.1016/j.ajoms.2018.06.007

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of induced pluripotent stem cells for cartilage regeneration in CLAWN miniature pig osteochondral replacement model2018

    • Author(s)
      Uto Sakura、Nishizawa Satoru、Hikita Atsuhiko、Takato Tsuyoshi、Hoshi Kazuto
    • Journal Title

      Regenerative Therapy

      Volume: 9 Pages: 58-70

    • DOI

      10.1016/j.reth.2018.06.003

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term follow-up of tracheal cartilage growth promotion by intratracheal injection of basic fibroblast growth factor2018

    • Author(s)
      Komura Makoto、Komura Hiroko、Komuro Hiroaki、Konishi Kenichiro、Obana Kazuko、Ikebukuro Kenichi、Hikita Atsuyuki、Hoshi Kazuto、Takato Tsuyoshi
    • Journal Title

      Journal of Pediatric Surgery

      Volume: 53 Issue: 12 Pages: 2394-2398

    • DOI

      10.1016/j.jpedsurg.2018.08.021

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of a scaffold for regenerative bone using 3-dimensional printer.2021

    • Author(s)
      疋田 温彦、星 和人、他
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Cell-type-distinct regulatory action of Runx2 on the genome underlies its distinct roles in osteoblasts and chondrocytes2019

    • Author(s)
      Hojo H, Ohba S et al
    • Organizer
      2019 Annual Meeting of the American Society for Bone and Mineral Research
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A chondrocyte-specific indian hedgehog enhancer as an OA-driving enhancer2019

    • Author(s)
      Yamakawa Akira, Hojo Hironori, Chung Ung-il, Ohba Shinsuke
    • Organizer
      ORS 2019 Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Exploring the gene regulatory landscape in skeletal cells2019

    • Author(s)
      Ohba Shinsuke
    • Organizer
      Gordon Research Conference Cartilage Biology & Pathology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] シンポジウム8【組織・機能を再現した体外培養系による薬効評価、病態解明】骨代謝ネットワーク再現系を用いた薬効評価2019

    • Author(s)
      疋田温彦,坂本朋昭,小口修矢,星 和人
    • Organizer
      第18回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] インプラント型再生軟骨移植を用いた唇裂鼻変形の修正術における顔貌変化の評価2018

    • Author(s)
      藤原夕子,西條英人,倉林くみ子,末永英之,浅輪幸世,西澤 悟,金澤三四朗,宇都さくら、稲木涼子,杉山 円,米永一理,疋田温彦,髙戸 毅,星 和人
    • Organizer
      第17回日本再生医療学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Identification of a chondrocyte-specific Indian hedgehog enhancer and Sox9-mediated mechanisms of the enhancer activation2018

    • Author(s)
      Yamakawa Akira, Hojo Hironori, Chung Ung-il, Ohba Shinsuke
    • Organizer
      2018 OARSI World Congress on Osteoarthritis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヘッジホッグシグナルと転写制御因子に着目した骨・軟骨形成機構の理解とその応用2018

    • Author(s)
      大庭伸介
    • Organizer
      第36回骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 硬組織の修復・再生科学の社会実装を目指して2018

    • Author(s)
      星 和人
    • Organizer
      第36回骨代謝学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] シンポジウム【運動器疾患の病態理解から治療法へ~iPS細胞技術を中心に】多能性幹細胞を用いた骨芽細胞分化のインビトロモデリングと分化機序解析への応用2018

    • Author(s)
      大庭伸介
    • Organizer
      第4回日本筋学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Tissue-engineered autologous cartilage for cleft lip-nose patients2018

    • Author(s)
      Hoshi Kazuto
    • Organizer
      5th TERMIS World Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Three-dimensional tissue-engineered cartilage using biodegradable polymers2018

    • Author(s)
      Hikita Atsuhiko
    • Organizer
      Frontiers 2018 Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Three-dimensional tissue-engineered cartilage for the secondary repair of cleft lip-nose deformity2018

    • Author(s)
      Hoshi Kazuto
    • Organizer
      13th Asian Congress of Oral & Maxillofacial Surgery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 【特別講演】遺伝子発現機構の研究においてNGSでできること・分かること・分からないこと2018

    • Author(s)
      大庭伸介
    • Organizer
      日本骨代謝学会Skeletal Science Retreat
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Book] 先進医療NAVIGATOR 再生医療・細胞医療の研究と産業化の最前線 第2章 14 骨再生医療等の現状と課題2019

    • Author(s)
      北條宏徳,鄭 裕一,大庭伸介
    • Total Pages
      93
    • Publisher
      日本医学出版(先進医療フォーラム 編)
    • ISBN
      9784865770308
    • Related Report
      2018 Annual Research Report
  • [Book] 「テキストブック再生医療~創る、行う、支える~」第1部 再生医療等の基盤 第1章:再生医療とは2019

    • Author(s)
      藤原夕子,髙戸 毅
    • Total Pages
      720
    • Publisher
      日本再生医療学会〈監修)
    • ISBN
      9784991059100
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-03-16  

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