• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Construction of a practical mathematical model that enables to evaluate the preventive effect of cancer screening considering both infection and vaccination

Research Project

Project/Area Number 18H03026
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionHiroshima University

Principal Investigator

Kakehashi Masayuki  広島大学, 医系科学研究科(保), 教授 (80177344)

Co-Investigator(Kenkyū-buntansha) 恒松 美輪子  広島大学, 医系科学研究科(保), 講師 (80704874)
川崎 裕美  広島大学, 医系科学研究科(保), 教授 (90280180)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsがん検診 / 数理モデル / シミュレーション / 感染 / 有効性評価
Outline of Final Research Achievements

This study aims at appropriate analysis and evaluation of the effectiveness of cancer screening by constructing a mathematical model of cancer screening using theoretical epidemiological methods. In particular, we will consider cases such as cervical cancer where viral infection and vaccination as a preventive measure affect the morbidity of cancer. Therefore, in this study, we collected related data on cervical cancer and HPV vaccination, created a simulation model of infection and cancer morbidity by age group, and performed the simulation of cancer screening and vaccine under various settings. The effect of implementing vaccination measures was evaluated.

Academic Significance and Societal Importance of the Research Achievements

感染症の流行や予防施策の評価については、数理モデルを使用した様々な分析が行われ、実際の予防施策の立案や評価に役立てられている。また、がん検診についても数理モデルを使用した分析や効果評価が進められている。しかし、感染が関与することで罹患するがんについては、この両方の側面を考慮した評価はこれからの課題である。本研究では、感染に対するワクチンによる予防効果とがん検診による早期発見に基づく寿命の延長効果を同時に分析し、がん検診の便益や害のバランスについて正確な情報提供により受診者の適切な判断に役立てたい。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (14 results)

All 2023 2021 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 6 results) Book (2 results)

  • [Journal Article] Trends in CD4+ Cell Counts, Viral Load, Treatment, Testing History, and Sociodemographic Characteristics of Newly Diagnosed HIV Patients in Osaka, Japan, From 2003 through 2017: A Descriptive Study2023

    • Author(s)
      Kagiura Fumiko、Matsuyama Ryota、Watanabe Dai、Tsuchihashi Yuuki、Kanou Kazuhiko、Takahashi Takuri、Matsui Yusuke、Kakehashi Masayuki、Sunagawa Tomimasa、Shirasaka Takuma
    • Journal Title

      Journal of Epidemiology

      Volume: 33 Issue: 5 Pages: 256-261

    • DOI

      10.2188/jea.JE20210150

    • NAID

      130008086704

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2023-05-05
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantifying the Effects of Medical Examination and Possible Risk Factors against the Incidence of Cervical Cancer in a Low Human Papillomavirus Vaccination Coverage: An Ecological Study in Japan2021

    • Author(s)
      Yu Yueming、Matsuyama Ryota、Tsunematsu Miwako、Kakehashi Masayuki
    • Journal Title

      Cancers

      Volume: 13 Issue: 19 Pages: 4784-4784

    • DOI

      10.3390/cancers13194784

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Influence of HPV vaccination to the distribution of multiple types of HPV2021

    • Author(s)
      Masayuki Kakehashi, Miwako Tsunematsu, Ryota Matsuyama
    • Organizer
      EPIDEMICS8
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of school class closure against seasonal influenza - An analysis on influenza epidemic based on student attendance records of four high schools2021

    • Author(s)
      Yukiko Masumoto, Ryota Matsuyama, Miwako Tsunematsu, Masayuki Kakehashi
    • Organizer
      EPIDEMICS8
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analyzing the incidence of cervical cancer in relation to those sexually transmitted diseases, disposable income, smoking rate, education-level in populations, and cancer screening rate in Japan2021

    • Author(s)
      Yueming Yu, Ryota Matsuyama, Miwako Tsunematsu, Masayuki Kakehashi
    • Organizer
      EPIDEMICS8
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of HIV incidence in age specific population in China2021

    • Author(s)
      Haoran Sun, Yueming Yu, Miwako Tsunematsu, Masayuki Kakehashi
    • Organizer
      EPIDEMICS8
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 季節性インフルエンザの高等学校における学級閉鎖の効果の検討2021

    • Author(s)
      増本由紀子, 松山亮太, 恒松美輪子, 梯 正之
    • Organizer
      第67回日本学校保健学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Association among cervical cancer, sexually transmitted diseases, smoking rate and testing rate in Japan2021

    • Author(s)
      Yu Y, Sun H, Matsuyama R, Tsunematsu M, Kakehashi M
    • Organizer
      日本疫学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Prediction of HIV incidence in China with simple SIR model2020

    • Author(s)
      Sun H, Yu , Matsuyama R, Tsunematsu M, Kakehashi M
    • Organizer
      日本公衆衛生学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 子宮頸がんの集団検診実施下にある集団におけるHPVワクチン接種の影響評価2020

    • Author(s)
      梯 正之、恒松美輪子、松山亮太
    • Organizer
      日本疫学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The Influence of the Absence of Human Papilloma Virus Vaccination in the Population under Mass Screening of Cervical Cancer2019

    • Author(s)
      Kakehashi M, Tsunematsu M, Matsuyama R
    • Organizer
      EPIDEMICS7
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Individually based stochastic model of influenza: An analysis of school closure2018

    • Author(s)
      Kakehashi M, Kawano S, Tsunematsu M
    • Organizer
      2018 Annual Meeting of the Society for Mathematical Biology & the Japanese Society for Mathematical Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] Handbook of Statistics Volume 44, Data Science: Theory and Applications2021

    • Author(s)
      Srinivasa Rao ASR, Rao CR (Lee TJ, Kakehashi M, Srinivasa Rao ASR)
    • Total Pages
      330
    • Publisher
      Elsevier North-Holland
    • ISBN
      9780323852005
    • Related Report
      2021 Annual Research Report
  • [Book] 人口学事典(執筆項目:感染症の人口学)2018

    • Author(s)
      日本人口学会、梯 正之(分担執筆)
    • Total Pages
      832
    • Publisher
      丸善出版
    • ISBN
      4621303074
    • Related Report
      2018 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi