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Epidemiological investigation of risk factors for childhood leukemia onset and adverse effects among survivors

Research Project

Project/Area Number 18H03044
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58020:Hygiene and public health-related: including laboratory approach
Research InstitutionNational Center for Child Health and Development

Principal Investigator

Urayama Kevin  国立研究開発法人国立成育医療研究センター, 社会医学研究部, シニアフェロー (60726850)

Co-Investigator(Kenkyū-buntansha) 高木 正稔  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (10406267)
真部 淳  北海道大学, 医学研究院, 教授 (20292849)
清河 信敬  国立研究開発法人国立成育医療研究センター, 小児血液・腫瘍研究部, 部長 (60195401)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2019: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywordsepidemiology / leukemia / genetics / pregnancy / perinatal factor / risk / 小児がん / 疫学 / 小児悪性腫瘍 / 母子保健 / リスク / 長期フォロー / 母子保健学
Outline of Final Research Achievements

We established the first epidemiological study of childhood hematological cancers (Epi-HCC) focusing on the examination of risk factors during pregnancy of the mother, birth characteristics, and early childhood exposures. We collected data from the Maternal and Child Health Handbook and saliva samples as a source of DNA, and several analyses have been completed and are also ongoing. Case and control comparisons show an association with maternal age, delivery methods, birthweight, and having older siblings. Through international collaboration (16 studies across 8 countries), we found that infection during pregnancy is associated with an increased risk of childhood leukemia. In genetic analyses, we identified 8 genetic loci associated childhood leukemia risk which have also been reported in non-Asian populations. We found two additional risk-associated genes which may be specific to the Japanese population.

Academic Significance and Societal Importance of the Research Achievements

Without a greater consensus on causes of childhood leukemia, effective disease prevention will not be possible. The results of this study informs what types of exposures during pregnancy and the child's early development, as well as genetic factors in Japanese, contributes to this disease.

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (11 results)

All 2022 2021 2018 Other

All Int'l Joint Research (6 results) Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Invited: 3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] University of California, Berkeley/University of Minnesota/University of Southern California(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] INSERM(フランス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Children's Cancer Hospital(エジプト)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] McGill University(カナダ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Danish Cancer Society(デンマーク)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Epidemiology of childhood leukemia: a targeted overview2021

    • Author(s)
      Kevin Y. Urayama
    • Journal Title

      Rinsho Ketsueki

      Volume: 62 Issue: 7 Pages: 733-738

    • DOI

      10.11406/rinketsu.62.733

    • NAID

      130008071864

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Maternal Infections and Childhood Leukemia Risk2022

    • Author(s)
      Kevin Y. Urayama
    • Organizer
      Annual Meeting of the Childhood Leukemia International Consortium
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Genetic and Environmental Contributions in the Risk of Childhood Leukemia2021

    • Author(s)
      Kevin Y. Urayama
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Epidemiology of Childhood Cancers: Perspectives from East Asia2018

    • Author(s)
      浦山ケビン
    • Organizer
      CLIC-I4C Joint International Symposium
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Funded Workshop] CLIC-I4C Joint International Symposium on "The Environment and Genetics in Pediatric Cancers: Epidemiological Advances through International Collaboration"2018

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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