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Development of personalized preventive method using genomic information and extracellular vesicles in general population cohort

Research Project

Project/Area Number 18H03054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionWakayama Medical University

Principal Investigator

Mure Kanae  和歌山県立医科大学, 医学部, 准教授 (90268491)

Co-Investigator(Kenkyū-buntansha) 下川 敏雄  和歌山県立医科大学, 医学部, 教授 (00402090)
服部 園美  和歌山県立医科大学, 保健看護学部, 教授 (00438285)
宮井 信行  和歌山県立医科大学, 保健看護学部, 教授 (40295811)
上松 右二  和歌山県立医科大学, 保健看護学部, 教授 (90223502)
竹下 達也  和歌山県立医科大学, 医学部, 教授 (20150310)
内海 みよ子  和歌山県立医科大学, 保健看護学部, 教授 (00232877)
志波 充  和歌山県立医科大学, 保健看護学部, 名誉教授 (50178894)
有田 幹雄  和歌山県立医科大学, 保健看護学部, 名誉教授 (40168018)
島袋 美絵  和歌山県立医科大学, 医学部, 学内助教 (70776939)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords個別化予防 / 動脈硬化 / 遺伝子型 / 細胞外小胞 / miRNA / 認知機能 / バイオマーカー / 分子栄養学 / ゲノム情報 / 糖尿病
Outline of Final Research Achievements

This study was aimed to adapt the "personalized prevention and preemptive medicine" to the general population to prevent the development of lifestyle-related diseases. Due to difficulties such as conducting the follow-up cohort study and unavailability of reagents produced overseas because of the COVID19 pandemic, the research could not be carried out as planned. However, in year 2022, we were able to conduct the follow-up survey and obtain the reagents smoothly, and the research has begun to progress. We have found that the effects of nutrients that are believed to have a preventive effect on atherosclerosis differ according to genotype, and results that will lead to the development of future research are being produced.

Academic Significance and Societal Importance of the Research Achievements

地域住民コホートにおいて、個人の遺伝子やタンパク質などの情報を基に最適な予防法を提示して介入する「個別化予防・先制医療」の実現のため、種々の遺伝子型(体質)の動脈硬化や栄養素の動脈硬化抑制効果へ影響、また動脈硬化の初期段階を予知できるマーカー開発を最終目的として行った。飲酒などの生活習慣が動脈硬化に与える影響や、動脈硬化に対して抑制的に作用する不飽和脂肪酸などの栄養素の効果も、特定の遺伝子の型(体質)で異なることが明らかとなった。また、酸化ストレスや内皮機能障害マーカーと関連する新たなマーカーの存在の可能性も示唆される成果を得た。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (31 results)

All 2022 2021 2020 2019 2018

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 3 results) Presentation (22 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Epidemiology of locomotive syndrome using updated clinical decision limits: 6 years follow-ups of the ROAD study2022

    • Author(s)
      Yoshimura N, Iidaka T, Horii C, Mure K, Muraki S. Oka H, Kawaguchi H, Akune T, Ishibashi H, Ohe T, Hashizume H, Yamada H, Yoshida M, Nakamura K, Tanaka S.
    • Journal Title

      J Bone Miner Metab

      Volume: 40 Issue: 4 Pages: 623-635

    • DOI

      10.1007/s00774-022-01324-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The combination of cigarette smoking and alcohol consumption synergistically increases reactive carbonyl species in human male plasma2021

    • Author(s)
      Mure K, Tomono S, Mure M, Horinaka M, Mutoh M, Sakai T, Ishikawa H, Wakabayashi K
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 16 Pages: 9043-9043

    • DOI

      10.3390/ijms22169043

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial2021

    • Author(s)
      Ishikawa H、Mutoh M、Sato Y、Doyama H、Tajika M、Tanaka S、Horimatsu T、Takeuchi Y、Kashida H、Tashiro J、Ezoe Y、Nakajima T、Ikematsu H、Hori S、Suzuki S、Otani T、Takayama T、Ohda Y、Mure K、Wakabayashi K、Sakai T
    • Journal Title

      The Lancet Gastroenterology & Hepatology

      Volume: - Issue: 6 Pages: 474-481

    • DOI

      10.1016/s2468-1253(21)00018-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan2020

    • Author(s)
      Uraoka Mirai、Shimizu Makiko、Kuwajima Yoshiki、Mizugaki Ami、Yokoyama Haruka、Mure Kanae、Yamazaki Hiroshi
    • Journal Title

      Current Drug Metabolism

      Volume: 21 Issue: 14 Pages: 1161-1164

    • DOI

      10.2174/1389200221666201009140802

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver Fibrosis is Associated with Loss of Skeletal Muscle Mass in Community-Dwelling Older Adults with No History of Liver Diseases2019

    • Author(s)
      大西修平,宮井信行,内海みよ子,牟礼佳苗,竹下達也,志波 充,有田幹雄
    • Journal Title

      Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

      Volume: 74 Issue: 0 Pages: n/a

    • DOI

      10.1265/jjh.18031

    • NAID

      130007602897

    • ISSN
      0021-5082, 1882-6482
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical polyneuropathy does not increase by pre‐diabetes or metabolic syndrome in Japanese general population2019

    • Author(s)
      Kurisu S, Sasaki H, Kishimoto S, Hirayasu M, Ogawa K, Matsuno S, Furuta H, Arita M, Naka K, Nanjo K, Akamizu T
    • Journal Title

      J Diabetes Investig.

      Volume: 0 Issue: 6 Pages: 1-30

    • DOI

      10.1111/jdi.13058

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Diarrhea after Drinking on Colorectal Tumor Risk: A Case Control Study2019

    • Author(s)
      Shiotani A, Ishikawa H, Mutoh M, Takeshita T, Nakamura T, Morimoto K, Sakai T, Wakabayashi K, Matsuura N.
    • Journal Title

      Asian Pac J Cancer Prev.

      Volume: 20 Issue: 3 Pages: 795-799

    • DOI

      10.31557/apjcp.2019.20.3.795

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Short-term Nap and Light Physical Exercise on Sleep among Elderly Patients with Mild-to-Moderate Dementia in Communal Living Group Homes2018

    • Author(s)
      堅木 亜起子, 宮井 信行
    • Journal Title

      Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene)

      Volume: 73 Issue: 3 Pages: 365-372

    • DOI

      10.1265/jjh.73.365

    • NAID

      130007492243

    • ISSN
      0021-5082, 1882-6482
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics and outcomes of elderly patients with diffuse gliomas: a multi-institutional cohort study by Kansai Molecular Diagnosis Network for CNS Tumors2018

    • Author(s)
      Sasaki Takahiro、Fukai Junya、Kodama Yoshinori、et al
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 140 Issue: 2 Pages: 329-339

    • DOI

      10.1007/s11060-018-2957-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 地域住民コホートにおけるサルコペニアと不飽和脂肪酸の関連2022

    • Author(s)
      土山徳季, 宮軒優希, 榎本真太, 渡井友貴, 寺田和史, 宮井信行, 牟礼佳苗
    • Organizer
      第93回日本衛生学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 地域住民コホートにおけるロコモティブシンドロームと酸化ストレス2022

    • Author(s)
      宮軒優希, 土山徳季, 榎本真太, 渡井友貴, 寺田和史, 宮井信行, 牟礼佳苗
    • Organizer
      第93回日本衛生学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] オステオサルコペニアの早期診断マーカーの可能性2022

    • Author(s)
      牟礼佳苗
    • Organizer
      第9回日本サルコペニアフレイル学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 因果媒介分析を用いたコーヒーと血圧関連指標におけるnutrigenetics研究2021

    • Author(s)
      笹山洋子,下川敏雄,西岡美子,牟礼佳苗
    • Organizer
      第91回日本衛生学会学術総会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] 因果媒介分析を用いた紅茶と脂質関連指標に おけるnutrigenetics研究2021

    • Author(s)
      笹山洋子,下川敏雄,西岡美子,牟礼佳苗
    • Organizer
      第91回日本衛生学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子型が決定する生活習慣と発がん抑制作用薬の効果2021

    • Author(s)
      牟礼佳苗
    • Organizer
      第91回日本衛生学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 遺伝子型が決定する生活習慣と発がん抑制作用薬の効果2021

    • Author(s)
      牟礼佳苗、J-CAPP Study IIグループ
    • Organizer
      第91回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 因果媒介分析を用いた紅茶と脂質関連指標におけるnutrigenetics研究2021

    • Author(s)
      西岡美子,下川敏雄,笹山洋子,牟礼佳苗
    • Organizer
      第91回日本衛生学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 多価不飽和脂肪酸による尿酸の抑制はNOS3(rs1799983)oyobiLRP2(rs2544390)多型に依存する2019

    • Author(s)
      上杉弥優,牟礼佳苗,服部園美,宮井信行,内海みよ子,上松右二,志波充,有田幹雄,竹下達也
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 酸化LDL受容体遺伝子OLR1多型が血圧・糖代謝・血中脂質・炎症指標に与える影響は服薬状況により異なる2019

    • Author(s)
      海老泰文,牟礼佳苗,中喬弘,上杉弥優,服部園美,宮井信行,内海みよ子,上松右二,志波充,有田幹雄,竹下達也
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 抗酸化酸素PON1遺伝子型が血圧・糖代謝・血中脂質・炎症指標に与える影響は服薬状況により異なる2019

    • Author(s)
      中喬弘,牟礼佳苗,海老泰文,上杉弥優,服部園美,宮井信行,内海みよ子,上松右二,志波充,有田幹雄,竹下達也
    • Organizer
      第89回日本衛生学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 日常生活下の動脈硬化症に対するチトクロムP450 2A6遺伝子型診断活用の可能性2019

    • Author(s)
      清水万紀子,浦岡未来,桑島愛生,野口みく,横山悠香,牟礼佳苗,山崎浩史
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] ASSOCIATION OF NOVEL RISK FACTORS OF CARDIOVASCULAR DISEASE WITH BAPWV IN A LARGE COHORT OF ADULTS2018

    • Author(s)
      Tateishi K, Mure K, Hayakawa H, Miyai N, Utsumi M, Uematsu Y, Takeshita T, Shiba M, Arita M
    • Organizer
      28th European meeting on Hypertension and Cardiovascular protection
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] LOW DENSITY LIPOPROTEIN CHOLESTEROL LEVEL,PULSE PRESSURE AND URIC ACID SSOCIATED WITH CAROTID INTIMA-MEDIA THICKNESS IN JAPANESE GENERAL POPULATION2018

    • Author(s)
      Fukui A, Mure K, Shimabukuro M, Miyai N, Utsumi M, Uematsu Y, Takeshita T, Shiba M, Arita M
    • Organizer
      28th European meeting on Hypertension and Cardiovascular protection
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高血圧チーム医療:農村地域における高血圧の予防と対策(保健師の立場から)2018

    • Author(s)
      植田京子,樫葉歩,大植知穂,小林啓晋,牟礼佳苗,竹下達也,宮井信行,内海みよ子,有田幹雄
    • Organizer
      第7回臨床高血圧フォーラム
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中年期の正常域血圧者における喫煙が運動負荷に伴う中心動脈圧波形の変化に及ぼす影響2018

    • Author(s)
      宮井信行,塩崎万起,長友奈央,寒川友起子,島袋美絵,牟礼佳苗,竹下達也,内海みよ子,宮下和久,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 年齢別にみた緑茶摂取量と動脈スティフネスの関連2018

    • Author(s)
      日置雄一郎,水越正人,宮井信行,竹下達也,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高齢高血圧患者における就寝前と起床後の血圧差が認知機能の低下と関連する2018

    • Author(s)
      阪口将登,岡俊文,宮井信行,小林啓晋,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 昼間と夜間の血圧変動が認知機能の低下の要因となりえるか2018

    • Author(s)
      岡俊文,阪口将登,小林啓晋,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 中学生におけるスポット尿によるNa/K 比と血圧との関連:わかやまヘルスプロモーション研究2018

    • Author(s)
      早川博子,宮井信行,寒川友起子,有馬美保,阿部香織,戸村多郎,内海みよ子,宮下和久,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 学齢期小児の心血管リスク評価における上腕 - 足首間脈波伝播速度のノモグラムの有用性の検討2018

    • Author(s)
      寒川友起子,宮井信行,川井美緒,内海みよ子,宮下和久,武田眞太郎,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 心臓足首血管指数(CAVI)を応用した高血圧患者の心血管事故評価2018

    • Author(s)
      橋爪俊和,有田幹雄
    • Organizer
      第41回日本高血圧学会総会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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