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The predictive ability of osteoporotic fractures for a risk of cardiovascular disease based on organ crosstalk :10-years follow-up of a cohort study for osteoporosis risk in men.

Research Project

Project/Area Number 18H03059
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionOsaka Medical College

Principal Investigator

Tamaki Junko  大阪医科大学, 医学部, 教授 (90326356)

Co-Investigator(Kenkyū-buntansha) 久藤 麻子  大阪医科大学, 医学部, 助教 (10289605)
林 江美  大阪医科大学, 医学部, 講師 (50445988)
千葉 康敬  近畿大学, 大学病院, 准教授 (80362474)
神谷 訓康  大阪医科大学, 医学部, 講師 (90780073)
伊木 雅之  近畿大学, 医学部, 教授 (50184388)
藤田 裕規  近畿大学, 医学部, 講師 (10330797)
上西 一弘  女子栄養大学, 栄養学部, 教授 (40232764)
顧 艶紅  大阪医科大学, 医学部, 講師 (30470595)
新田 明美  大阪医科大学, 医学部, 助教 (00737744)
池原 賢代  大阪医科大学, 医学部, 講師 (70589465)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2018: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords骨粗鬆症 / 骨粗鬆症性骨折 / 動脈硬化 / 脳心血管疾患 / 男性 / 地域在住高齢者 / 前向きコホート研究 / 骨―血管連関 / 骨折 / コホート研究 / 地域在住男性高齢者
Outline of Final Research Achievements

We conducted the 10-year follow-up survey in the FORMEN cohort study, and identified the events of cardiovascular diseases in 1455 subjects during the 10-year follow-up period. In 1455 subjects, osteoporosis or past history of osteoporotic fracture at the baseline were not related with the risks of cardiovascular diseases, while osteoporosis or past history of osteoporotic fracture at the baseline were related with the risks of cardiovascular diseases and stroke with marginal significance in 1333 subjects with no history of cardiovascular diseases at the baseline. In 1101 subjects with no history of cardiovascular diseases at the baseline and whose SBP were equal or more than 130mmHg, or DBP were equal or more than 80 mmHg, osteoporosis or past history of osteoporotic fracture at the baseline were significantly related with elevated risks of cardiovascular diseases and stroke after adjusting for risk factors for cardiovascular diseases.

Academic Significance and Societal Importance of the Research Achievements

今回の縦断的研究によって、我が国の地域在住の高齢男性において骨脆弱性を呈する者ではその後の脳心血管疾患発生リスクが高まる可能性が示された。これまで日本人女性では、骨脆弱性があると動脈硬化の度合いが高まる可能性が報告されているが、骨―血管連関について日本人男性の縦断的検討で示されたのは、我々の知る限り本邦初である。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(15 results)

All 2021 2020 2019 2018 Other

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (8 results) (of which Int'l Joint Research: 3 results) Remarks (2 results)

  • [Journal Article] Associations between trunk-to-peripheral fat ratio and cardiometabolic risk factors in elderly Japanese men: baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study2021

    • Author(s)
      Kouda Katsuyasu、Fujita Yuki、Ohara Kumiko、Tachiki Takahiro、Tamaki Junko、Yura Akiko、Moon Jong-Seong、Kajita Etsuko、Uenishi Kazuhiro、Iki Masayuki
    • Journal Title

      Environ Health Prev Med

      Volume: 26 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s12199-021-00959-9

    • NAID

      210000158918

    • ISSN
      1342-078X, 1347-4715
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating osteocalcin levels were not significantly associated with the risk of incident type 2 diabetes mellitus in elderly Japanese men: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2021

    • Author(s)
      Iki Masayuki、Yura Akiko、Fujita Yuki、Kouda Katsuyasu、Tamaki Junko、Tachiki Takahiro、Kajita Etsuko、Iwaki Hirohisa、Ishizuka Rika、Moon Jong-Seong、Okamoto Nozomi、Kurumatani Norio
    • Journal Title

      Bone

      Volume: 147 Pages: 115912-115912

    • DOI

      10.1016/j.bone.2021.115912

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships between serum uric acid concentrations, uric acid lowering medications, and vertebral fracture in community-dwelling elderly Japanese men: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2020

    • Author(s)
      Iki Masayuki、Yura Akiko、Fujita Yuki、Kouda Katsuyasu、Tachiki Takahiro、Tamaki Junko、Sato Yuho、Moon Jong-Seong、Hamada Masami、Kajita Etsuko、Okamoto Nozomi、Kurumatani Norio
    • Journal Title

      Bone

      Volume: 139 Pages: 115519-115519

    • DOI

      10.1016/j.bone.2020.115519

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased risk of osteoporotic fracture in community-dwelling elderly men 20 or more years after gastrectomy: The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2019

    • Author(s)
      Iki Masayuki、Fujita Yuki、Kouda Katsuyasu、Yura Akiko、Tachiki Takahiro、Tamaki Junko、Sato Yuho、Moon Jong-Seong、Hamada Masami、Kajita Etsuko、Okamoto Nozomi、Kurumatani Norio
    • Journal Title

      Bone

      Volume: 127 Pages: 250-259

    • DOI

      10.1016/j.bone.2019.06.014

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperglycemic status is associated with an elevated risk of osteoporotic fracture in community-dwelling elderly Japanese men: The Fujiwara-kyo osteoporosis risk in men (FORMEN) cohort study.2019

    • Author(s)
      Iki M, Fujita Y, Kouda K, Yura A, Tachiki T, Tamaki J, Sato Y, Moon JS, Hamada M, Kajita E, Okamoto N, Kurumatani N.
    • Journal Title

      Bone

      Volume: 121 Pages: 100-106

    • DOI

      10.1016/j.bone.2019.01.005

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 地域在住高齢男性における貧血と脆弱性骨折との関連 藤原京スタディ男性骨粗鬆症コホート研究(FORMEN study)の5年追跡(会議録)2020

    • Author(s)
      貫井 裕次, 玉置 淳子, 藤田 裕規, 甲田 勝康, 立木 隆広, 梶田 悦子, 濱田 昌実, 神谷 訓康, 岡本 希, 伊木 雅之
    • Organizer
      日本骨粗鬆症学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 地域在住高齢男性における貧血と脆弱性骨折との関連-藤原京スタディ男性骨粗鬆症コホート研究(FORMEN study)の5年追跡2020

    • Author(s)
      貫井裕次、玉置淳子、藤田裕規、甲田勝康、立木隆広、梶田悦子、濱田昌実、神谷訓康、岡本希、伊木雅之
    • Organizer
      第22回日本骨粗鬆症学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gastrectomy is associated with increased risk of osteoporotic fracture in community-dwelling elderly men 20 years or more after the surgery: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2019

    • Author(s)
      Masayuki Iki, Yuki Fujita, Katsuyasu Kouda, Akiko Yura, Takahiro Tachiki, Junko Tamaki, Yuho Sato, Jong-Seong Moon, Masami Hamada, Etsuko Kajita, Nozomi Okamoto, and Norio Kurumatani
    • Organizer
      46th European Calcified Tissue Society Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シスタチンCに基づくeGFR低値は骨粗鬆症性骨折リスク上昇と関連したが、クレアチニンに基づくeGFRは関連しなかった 藤原京スタディ男性骨粗鬆症コホート研究2019

    • Author(s)
      伊木 雅之, 藤田 裕規, 甲田 勝康, 由良 晶子, 立木 隆広, 玉置 淳子, 佐藤 裕保, 梶田 悦子, 岡本 希, 車谷 典男
    • Organizer
      日本骨粗鬆症学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 貧血と脆弱性骨折との関連 藤原京スタディ男性骨粗鬆症コホート研究による縦断的検討2019

    • Author(s)
      貫井 裕次, 玉置 淳子, 藤田 裕規, 梶田 悦子, 甲田 勝康, 由良 晶子, 立木 隆広, 神谷 訓康, 佐藤 裕保, 伊木 雅之, 岡本 希, 車谷 典男
    • Organizer
      日本公衆衛生学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 地域在住高齢男性における胃切除後の骨折リスク上昇 藤原京スタディ男性骨粗鬆症研究2019

    • Author(s)
      伊木 雅之, 藤田 裕規, 甲田 勝康, 由良 晶子, 立木 隆広, 玉置 淳子, 佐藤 裕保, 梶田 悦子, 濱田 昌実, 岡本 希, 車谷 典男
    • Organizer
      日本骨形態計測学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Gastrectomy is associated with increased risk of osteoporotic fracture in community-dwelling elderly men 20 years or more after the surgery: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2019

    • Author(s)
      Iki M, Fujita Y, Kouda K, Yura A, Tachiki T, Tamaki J, Sato Y, Moon JS, Hamada M, Kajita E, Okamoto N, and Kurumatani N
    • Organizer
      the 46th annual meeting of the European Calcified Tissue Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Higher levels of serum uric acid were associated with lower risk of vertebral fracture indpendenly of bone density and renal function. Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study2018

    • Author(s)
      Iki M, Fujita Y, Yura A, Kouda K, Tachiki T, Sato Y, Tamaki J, Kajita E, Moon JS, Okamoto N, Kurumatani N
    • Organizer
      World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 藤原京スタディ男性骨粗鬆症研究

    • URL

      https://www.med.kindai.ac.jp/pubheal/FORMEN/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 近畿大学医学部公衆衛生学教室ホームページ 藤原京スタディ男性骨粗鬆症(FORMEN)研究

    • URL

      https://www.med.kindai.ac.jp/pubheal/FORMEN/index.html

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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