| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Outline of Final Research Achievements |
We analyzed the roles of cytokines/chemokines in thymic atrophy using murine restraint stress model. When WT mice were restrained, the thymus was significantly involuted. However,in Cx3cr1-deficient mice treated with the same manner, the thymic atrophy was significantly suppressed. Subsequently, we examined apoptotic cells in the thymus of WT and Cx3cr1-deficient mice. Restrain stress induced the apoptosis in the thymic cells of WT mice. However,the absence of Cx3cr1 significantly suppressed apoptosis of thymic cells. In line with this,the intrathymic gene expression of Fas ligand was significantly attenuated in Cx3cr1 deficient mice．Moreover, blood cortisol level was suppressed in restrain stress-treated Cx3cr1-deficient mice. These observations implied that the absence of CX3CR1 resisted stress-induced thymic atrophy. Thus, CX3CR1-mdiated signals would promote thymic involution induced by restrain stress. CX3CR1 would be a key molecule for diagnosing abuse in infants and children.
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