Therapeutic strategies for physiotherapy to control chronic inflammation and macrophages for diabetic microangiopathy
| Project/Area Number |
18H03130
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Kobe University |
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Principal Investigator |
Fujino Hidemi 神戸大学, 保健学研究科, 教授 (20278998)
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| Co-Investigator(Kenkyū-buntansha) |
近藤 浩代 名古屋女子大学, 健康科学部, 准教授 (50333183)
石原 昭彦 京都大学, 人間・環境学研究科, 教授 (90184548)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Keywords | 超音波 / 低酸素 / 慢性炎症 / マクロファージ / 微小血管症 / 糖尿病 / 骨格筋 / 単球 / 細胞外小胞 / 神経 |
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| Outline of Final Research Achievements |
Regulation of inflammatory macrophages could delay the progression of diabetic complications. In this study, we tested whether physical therapies such as ultrasound and hypoxic stimulation are effective in suppressing chronic microinflammatory effects. Ultrasound irradiation increased extracellular vesicle release and IRG1 expression. Metabolomics analysis showed that itaconic acid increased NRF2 expression, which suppressed the expression of inflammatory factors. Similarly, hypoxic stimulation also promoted the release of extracellular vesicles, increased HIF-1α and Rab39b expression, and attenuated the effects of inflammatory macrophages. These results suggest that physical therapy can have a modulatory effect on chronic microinflammatory effects.
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| Academic Significance and Societal Importance of the Research Achievements |
慢性微小炎症は糖尿病性合併症の進行の起因となり、運動，食事等により制御されているが，これらの療法は長期間の持続性、年齢、対象者により制限がある。そこで負担の少ない慢性微小炎症の予防法を開発することが必要であると考え、超音波や低酸素環境刺激による物理療法について検証した。本研究で検証した超音波や低酸素環境は慢性微小炎症に関連する炎症型マクロファージを制御できることが明らかになった。超音波や低酸素環境は負担の少ない予防法であり、日常生活の中に取り入れて、合併症や加齢の進行予防が可能となる。本研究の成果は糖尿病や加齢等で生じる慢性微小炎症に伴う合併症を物理療法で制御できる可能性を示唆したことである。
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Report
(4 results)
Research Products
(89 results)
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[Journal Article] Acute Effects of Combination Therapy by Triceps Surae Stretching and Electrical Stimulation to the Tibialis Anterior on Medial Forefoot Plantar Pressure During Gait in Patients With Diabetes Mellitus.2023
Author(s)
Maeshige N, Moriguchi M, Fujii M, Kanazawa H, Yoshikawa Y, Kitamura K, Okuno F, Yamaguchi A, Uemura M, Hosomi M, Hara K, Terashi H, Fujino H
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Journal Title
Int J Low Extrem Wounds.
Volume: ー
Pages: 153-153
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Brazilian propolis intake decreases body fat mass and oxidative stress in community-dwelling elderly females: A randomized placebo-controlled trial.2023
Author(s)
Kanazashi M, Iida T, Nakanishi R, Tanaka M, Ikeda H, Takamiya N, Maeshige N, Kondo H, Nishigami T, Harada T, Fujino H.
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Journal Title
Nutrients
Volume: 15
Issue: 2
Pages: 364-364
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Skeletal myotube-derived extracellular vesicles enhance itaconate production and attenuate inflammatory responses of macrophages2023
Author(s)
Yamaguchi A, Maeshige N, Yan J, Ma X, Uemura M, Matsuda M, Nishimura Y, Hasunuma T, Kondo H, Fujino H, Yuan ZM.
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Journal Title
Front Immunol
Volume: 14
Pages: 1099799-1099799
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Preventive effects of low-intensity exercise on cancer cachexia-induced muscle atrophy2019
Author(s)
Tanaka M, Sugimoto K, Fujimoto T, Xie K, Takahashi T, Akasaka H, Kurinami H, Yasunobe Y, Matsumoto T, Fujino H, Rakugi H
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Journal Title
FASEB J
Volume: 27
Issue: 7
Pages: 7852-7862
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibitory Effects of Short-Chain Fatty Acids and ω-3 Polyunsaturated Fatty Acids on Profibrotic Factors in Dermal Fibroblasts2019
Author(s)
Maeshige N, Torii K, Tabuchi H, Imai M, Koga Y, Uemura M, Aoyama-Ishikawa M, Miyoshi M, Fujino H, Terashi H, Usami M
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Journal Title
NAID
Related Report
Peer Reviewed
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[Presentation] Effects of Transcutaneous Application of Carbon Dioxide on diabetic muscle atrophy2018
Author(s)
Kondo H, Tani T, Naito K, Niimi Y, Nakane M, Sugiyama Y, Okayasu K, Takemoto H, Matsumoto T, Takuwa M, Hirabayashi T Ikeji T, Ono K, Fujino H
Organizer
Experimental Biology (San Diego)
Related Report
Int'l Joint Research
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