Role of the cerebellum and basal ganglia for functional recovery in patients with hemiparetic stroke

• Project/Area Number: 18H03135
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Fujita Health University
• Principal Investigator: Yohei Otaka 藤田医科大学, 医学部, 教授 (00317257)
• Co-Investigator(Kenkyū-buntansha): 井澤 淳 筑波大学, システム情報系, 准教授 (20582349) ; 荒牧 勇 中京大学, スポーツ科学部, 教授 (40414023) ; 川上 途行 慶應義塾大学, 医学部(信濃町), 講師 (80424133)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2018: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 運動学習 / 脳卒中 / リハビリテーション / 機能回復 / 脳画像解析

Outline of Final Research Achievements

The present study purposed to systematically understand the relationship between the function of learning mechanisms and brain lesions in post-stroke patients, based on a variety of experimental and clinical parameters. We, in particular, evaluated the learning function in post-stroke hemiparetic patients and investigated its influence on their clinical outcomes. The present study successfully developed an experimental task that can evaluate the learning function and a framework of experimental design to address the above questions. Future studies with a large number of participants may further facilitate a comprehensive understanding of the relationship between the learning function and clinical outcomes.

Academic Significance and Societal Importance of the Research Achievements

リハビリテーション訓練の多くは、学習を前提として設計されているにも関わらず、その基盤となる脳内運動学習メカニズムがどのように機能回復を担っているか未だに解明されていない。本研究は、脳卒中患者の学習能力が病態や機能的帰結に及ぼす影響を理解するための基盤研究として、そのフレームワークを構築することができた。

Research Products

• [Journal Article] Factors related to daily use of the paretic upper limb in patients with chronic hemiparetic stroke- A retrospective crosssectional study (2021)
  • Author(s): Syoichi Tashiro, Miho Kuroki, Kohei Okuyama, Osamu Oshima, Miho Ogura, Nanako Hijikata, Takuya Nakamura, Asako Oka, Michiyuki Kawakami, Tetsuya Tsuji, Meigen Liu
  • Journal Title: PlosOne Volume: 16 Issue: 3 Pages: e0247998-e0247998
  • DOI: 10.1371/journal.pone.0247998
  • Peer Reviewed / Open Access
• [Journal Article] Item difficulty of Fugl-Meyer Assessment for Upper Extremity in persons with chronic stroke with moderate-to-severe upper limb impairment. (2020)
  • Author(s): Hijikata N, Kawakami M, Ishii R, Tsuzuki K, Nakamura T, Okuyama K, Liu M.
  • Journal Title: Front Neurol. Volume: -
  • DOI: 10.3389/fneur.2020.577855
  • Peer Reviewed / Open Access
• [Journal Article] Depth Sensor-Based Assessment of Reachable Work Space for Visualizing and Quantifying Paretic Upper Extremity Motor Function in People With Stroke (2020)
  • Author(s): Kohei Okuyama, Michiyuki Kawakami, Shohei Tsuchimoto, Miho Ogura, Kohsuke Okada, Katsuhiro Mizuno, Junichi Ushiba, Meigen Liu
  • Journal Title: Physical Therapy Volume: 100 Issue: 5 Pages: 870-879
  • DOI: 10.1093/ptj/pzaa025
  • Peer Reviewed / Open Access
• [Journal Article] 競技スポーツの脳構造画像解析 (2020)
  • Author(s): 荒牧勇
  • Journal Title: Clinical Neuroscience Volume: 38 Pages: 732-735