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Development of Combined Constraint-induced Movement Therapy with Neurofeedback for Severe Upper Limb Paralysis

Research Project

Project/Area Number 18H03136
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionHyogo Medical University

Principal Investigator

Kazuhisa Domen  兵庫医科大学, 医学部, 教授 (50207685)

Co-Investigator(Kenkyū-buntansha) 小山 哲男  兵庫医科大学, 医学部, 特別招聘教授 (40538237)
内山 侑紀  兵庫医科大学, 医学部, 准教授 (50725992)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Keywords上肢 / ロボット / 活動 / リハビリテーション / CI療法 / ロボットリハビリテーション / 上肢機能障害 / ニューロリハビリテーション / 非侵襲的脳刺激 / 運動学習 / 脳卒中 / 非侵襲的脳刺激法 / 上肢機能 / ニューロフィードバック / CI療法
Outline of Final Research Achievements

Constraint-induced Movement Therapy (CIMT) combined with an upper limb rehabilitation support robot for stroke patients with severe upper limb paralysis was found to improve upper limb function. The results also indicated that the combination of CIMT with transcranial direct current electrical stimulation and peripheral neuromuscular electrical stimulation may further enhance the effects of regular CIMT. The results of the study of upper limb activity using a wearable activity meter revealed that while there was no significant long-term decline in patient-reported frequency of upper limb use, there were relatively many cases in which the ratio of upper limb activity on the paralyzed side to that on the nonparalyzed side gradually decreased.

Academic Significance and Societal Importance of the Research Achievements

重度の上肢麻痺を呈する脳卒中患者に対し、従来は治療の選択肢が限られていたが、様々な治療法を組み合わせることで、上肢機能の改善やの脳血流の変化が得られることが明らかとなり、重度の上肢麻痺に対する治療法の可能性が得られた。しかしながら、麻痺側上肢の活動量は治療後に長期的に徐々に低下していくケースが多いことも判明した。本研究の結果から、上肢麻痺に対する治療においては、実生活において上肢の活動量を増加させるための方策が必要不可欠である、という新たな課題にも直面した。本研究の結果は今後の上肢麻痺治療の発展の方向性に大きく影響を与える可能性があり、非常に重要な意義があったと考える。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (12 results)

All 2022 2021 2019 2018

All Journal Article (1 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 8 results)

  • [Journal Article] 上肢機能障害の治療をどう考えていくか?2021

    • Author(s)
      内山侑紀, 道免和久
    • Journal Title

      The Japanese Journal of Rehabilitation Medicine

      Volume: 58 Pages: 66-74

    • NAID

      130007998810

    • Related Report
      2021 Annual Research Report
  • [Presentation] 上肢機能障害に対するロボットリハビリテーション2022

    • Author(s)
      内山侑紀、岩佐沙弥、道免和久
    • Organizer
      第95回日本整形外科学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ニューロリハビリテーション 最新情報と未来に向けて2022

    • Author(s)
      内山侑紀、岩佐沙弥、道免和久
    • Organizer
      第6回日本リハビリテーション医学会秋季学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 脳卒中上肢のロボットリハビリテーション2022

    • Author(s)
      内山侑紀、岩佐沙弥、道免和久
    • Organizer
      第59回日本リハビリテーション医学会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 上肢リハビリテーション支援ロボットの臨床実践と課題2022

    • Author(s)
      内山侑紀、道免和久
    • Organizer
      第13回日本ニューロリハビリテーション学会学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Impact of Repeated Treatment by Modified Constraint-Induced Movement Therapy Combined with Robotic Training in A Chronic Stroke Patient with Severe Upper Limb Paralysis2022

    • Author(s)
      Yuki Uchiyama, Saya Iwasa, Kazuhisa Domen
    • Organizer
      12th World Congress of Neurorehabilitation
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CI療法とロボットリハビリテーション2021

    • Author(s)
      内山侑紀, 道免和久
    • Organizer
      第46回日本脳卒中学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 脳卒中上肢リハビリテーション支援ロボットの実際と課題2021

    • Author(s)
      内山侑紀, 岩佐沙弥, 道免和久
    • Organizer
      第5回日本リハビリテーション医学会秋季学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 脳卒中リハビリテーション-常識から最先端まで-2021

    • Author(s)
      道免和久
    • Organizer
      医療と介護の総合展
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Improvement of Upper Extremity Function after Constraint-Induced Movement Therapy Combined with Robotic Training Following Botulinum Toxin Injection in Patients with Chronic Severe-Moderate Hemiparesis after Stroke2019

    • Author(s)
      Yukihisa Hashimoto, Satoru Amano, Atsushi Umeji, Akira Uchita, Yuki Uchiyama, Kazuhisa Domen
    • Organizer
      13th International Society of Physical and Rehabilitation Medicine World Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multimodal Neurorehabilitation for Upper Limb Paralysis2019

    • Author(s)
      Kazuhisa Domen, Yuki Uchiyama
    • Organizer
      13th International Society of Physical and Rehabilitation Medicine World Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CI療法前後に近赤外分光法を用いた脳機能マッピングの課題依存的変化を検討した2例2018

    • Author(s)
      内山侑紀,深井茉由佳,長谷川恭子,宮部由利,山下泰治,児玉典彦,道免和久
    • Organizer
      第55回日本リハビリテーション医学会学術集会
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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