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XEpigenetic mechanisms for age-associated decline in physiological function

Research Project

Project/Area Number 18H03147
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionShinshu University

Principal Investigator

Nose Hiroshi  信州大学, 医学部, 特任教授 (40128715)

Co-Investigator(Kenkyū-buntansha) 松田 和之  信州大学, 学術研究院保健学系, 教授 (00647084)
森川 真悠子  信州大学, 先鋭領域融合研究群バイオメディカル研究所, 助教(特定雇用) (10596068)
樋口 京一  信州大学, 学術研究院医学系, 教授 (20173156)
増木 静江  信州大学, 学術研究院医学系, 教授 (70422699)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2018: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords老化 / 筋委縮 / カウンターメジャー / インターバル速歩 / エピジェネティック効果 / 筋萎縮 / カウンターメージャー
Outline of Final Research Achievements

The purpose of the present study was to examine the hypotheses that the dysfunction of mitochondria by deteriorated physical fitness with aging caused various age-associated diseases and that a long term interval walking training (IWT) was one of the effective counter measures to prevent this.
To do this, we compared physical fitness, the symptoms of age associated diseases, and the activity of NFkB2 gene, which was known as a key gene to cause chronic inflammation in the body, between older subjects who had performed IWT for 10 years (IWT-G, n=130) and those who had not performed for any periods before (CNT-G, n=146) by a cross over study.
As a result, we found the higher physical fitness, the lighter symptoms of age-associated diseases, and the greater methylation of NFkB2 gene over 71 years old in IWT-G than in CNT-G. These results support our hypotheses.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、体力維持・向上のための10年にわたる長期間の運動トレーニングが炎症促進遺伝子の不活性化を介して、加齢性疾患の症状を改善することを明らかにしたことである。このことは「ヒトの老化メカニズム」について、遺伝子と環境因子の相互作用から明らかにする試みで新しい研究分野の開拓につながる。
また、社会的意義としては、超高齢化社会に突入し医療費の高騰が危惧されている中、長期間の体力の維持向上のための運動トレーニングの有用性を遺伝子から個体レベルに至るまで一気通貫で明らかにしたことで、今後中高年者の運動習慣の定着に向けての社会的システム構築に向けて重要な科学的エビデンスになる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (43 results)

All 2021 2020 2019 2018 2017 Other

All Journal Article (15 results) (of which Peer Reviewed: 12 results,  Open Access: 2 results) Presentation (14 results) (of which Int'l Joint Research: 8 results,  Invited: 6 results) Book (9 results) Remarks (2 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Effects of 5-aminolevulinic acid with iron supplementation on respiratory responses to graded cycling and interval walking training achievement in older women over 75 yrs2021

    • Author(s)
      Ichihara Y, Masuki S, Uchida K, Takahashi K, Nakajima M, and Nose H
    • Journal Title

      Exp Gerontol

      Volume: 150 Pages: 111356-111356

    • DOI

      10.1016/j.exger.2021.111356

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-intensity interval walking training using internet of things (IoT): post and future2021

    • Author(s)
      Nose H, Morikawa M, Furihata M, and Masuki S
    • Journal Title

      J Phs Fitness Sports Med

      Volume: 10 Pages: 001-006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Internet of Things (IoT) system and field sensors for exercise intensity measurements2020

    • Author(s)
      Masuki S, Morikawa M, and Nose H
    • Journal Title

      Comprehensive Physiology

      Volume: 10 Pages: 1207-1240

    • DOI

      10.1002/cphy.c190010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Countdown before voluntary exercise induces muscle vasodilation with baroreflex mediated decrease in muscle sympathetic nerve activity in humans2020

    • Author(s)
      Manabe K, Masuki S, Ogawa Y, Uchida K, Kamijo Y, Kataoka Y, Sumiyoshi E, Takeda Y, Aida T, Nose H
    • Journal Title

      J Appl Physiol

      Volume: 128 Issue: 5 Pages: 1196-1206

    • DOI

      10.1152/japplphysiol.00523.2019

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mathematical model to estimate the increase in firefighters’ core temperature during firefighting activity with a portable calorimeter2020

    • Author(s)
      Kimura T, Ogawa Y, Hayashi H, Yasumitsu R, Kataoka Y, Uchida K, Manabe K, Masuki S, and Nose H
    • Journal Title

      Int J Biometeorol

      Volume: 64 Issue: 5 Pages: 755-764

    • DOI

      10.1007/s00484-020-01865-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High intensity walking time is a key determinant to increase physical fitness and improve health outcomes after interval walking training in middle-aged and older people2019

    • Author(s)
      Masuki S, Morikawa M, Nose H
    • Journal Title

      Mayo Clinic Proceedings

      Volume: 94 Pages: 2415-2426

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 10歳若返る!「インターバル速歩」-生活習慣病・介護予防のための新しい運動処方システム-2019

    • Author(s)
      能勢 博、森川真悠子、増木静江
    • Journal Title

      月間せんい

      Volume: 72 Pages: 101-107

    • NAID

      40021820622

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 運動と乳製品摂取で熱中症を予防する、In: 一歩先ゆく熱中症・脱水予防2019

    • Author(s)
      能勢 博、内田晃司、森川真悠子、増木静江
    • Journal Title

      救急医学

      Volume: 43 Pages: 942-948

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 糖尿病患者向けの効果的な歩行のコツ-インターバル速歩のススメ―2019

    • Author(s)
      能勢 博、森川真悠子、降幡真由佳、増木静江
    • Journal Title

      Modern Physician

      Volume: 39 Pages: 49-52

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Seasonal influence on adherence to and effects of an interval walking training program on sedentary female college students in Japan2018

    • Author(s)
      Tanabe A, Masuki S, Nemoto K, and Nose H
    • Journal Title

      Int J Biometeorol

      Volume: 62 Issue: 4 Pages: 643-654

    • DOI

      10.1007/s00484-017-1473-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of dried tofu supplementation during interval walking training on the methylation of NFKB2 gen in the whole blood of older women2018

    • Author(s)
      Morikawa M, Nakano S, Mitsui N, Murasawa H, Masuki S, and Nose H
    • Journal Title

      J Physiol Sci

      Volume: - Issue: 6 Pages: 749-757

    • DOI

      10.1007/s12576-017-0589-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Barometric pressure change and heart rate response during sleeping at 3000m2018

    • Author(s)
      Horiuchi M, Endo J, Handa Y, and Nose H
    • Journal Title

      Int J Biometeorol

      Volume: - Issue: 5 Pages: 909-912

    • DOI

      10.1007/s00484-017-1487-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid saline infusion and/or drinking enhance skin sympathetic nerve activity components reduced by hypovolaemia and hyperosmolality in hyperthermia2018

    • Author(s)
      Kamijo Yoshi-ichiro、Okazaki Kazunobu、Ikegawa Shigeki、Okada Yoshiyuki、Nose Hiroshi
    • Journal Title

      The Journal of Physiology

      Volume: 596 Issue: 22 Pages: 5443-5459

    • DOI

      10.1113/jp276633

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of 5-aminolevulinic acid supplementation on home-based walking training achievement in middle-aged deppressive women: randomized, double-blind, crossover pilot srudy2018

    • Author(s)
      Suzuki H, Masuki S, Morikawa A, Ogawa Y, Kamijo Y, Takahashi K, Nakajima M, and Nose H
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 7151-7151

    • DOI

      10.1038/s41598-018-25452-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interval walking training and nutritional intake to increase plasma volume in elderly2017

    • Author(s)
      Uchida K, Kamijo Y, Ikegawa S, Hamada K, Masuki S, and Nose H
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 50 Issue: 1 Pages: 151-158

    • DOI

      10.1249/mss.0000000000001416

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] インターバル速歩2021

    • Author(s)
      能勢 博、増木静江
    • Organizer
      第85回日本温泉気候物理学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] より有効な有酸素運動の工夫2020

    • Author(s)
      能勢 博、増木静江
    • Organizer
      第54回糖尿病学の進歩
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 10歳若返る!「インターバル速歩」-その現状と将来展望―2020

    • Author(s)
      能勢 博、増木静江
    • Organizer
      第20回日本加齢医学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Enhanced cerebro-cardiovascular responses before voluntary cycling in physically fit men2019

    • Author(s)
      Manabe K, Masuki S, Uchida K, Takeda Y, and Nose H
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lower urinary tract symptoms are associated with reduced peak aerobic capacity in old people.2019

    • Author(s)
      Takeda Y, Masuki S, Morikawa M, and Nose H
    • Organizer
      The 9th Federation of the Asian and Oceanian Physiological Societies Congress,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 10歳若返る!「インターバル速歩」-その背景と効果のエビデンス-2019

    • Author(s)
      能勢 博
    • Organizer
      第56回日本臨床生理学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 運動+乳製品摂取で生活習慣病予防-慢性腎臓病患者への応用の可能性-2019

    • Author(s)
      能勢 博
    • Organizer
      第12回山形臨床水・電解質研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 糖尿病にはインターバル速歩-無理せず続けられる効果的な運動療法-2019

    • Author(s)
      能勢 博
    • Organizer
      第52回北信糖尿病カンファレンス
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] High intensity walking time is a key determinant to increase VO2peak after 5-month interval walking training in middle-aged and older people2018

    • Author(s)
      Masuki S, Morikawa M, Nose H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Countdown before voluntary exercise induces muscle vasodilation with decreased muscle sympathetic nerve activity in humans2018

    • Author(s)
      Manabe K, Masuki S, Ogawa Y, Uchida K, Kamijo Y, Kataoka Y, Sumiyoshi E, Aida T and Nose H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Milk plus carbohydrate supplementation during interval walking training enhanced the improvement of blood glucose and blood pressure regulations in older people.2018

    • Author(s)
      Uchida K, Masuki S, Morikawa M, Furihata M, Manabe K, Ogawa Y, Kataoka Y, Aida T, Nakano S and and Nose H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of the high pressure processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in lifestyle-related disease patients2018

    • Author(s)
      Aida T, Masuki S, Uchida K, Manabe K, Morikawa M, Furihata M, Fujita T and Nose H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of 5-month interval walking training on cognitive function in elderly people2018

    • Author(s)
      Furihata M, Morikawa M, Hayashi R, Tomita W, Masuki S, and Nose H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Interval walking training over 10 years protects against age-associated declines in physical fitness2018

    • Author(s)
      Morikawa M, Masuki S, Furuhata S, Shimodaira H, Furihata M, and Nose H
    • Organizer
      Experimental Biology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] インターバル速歩で健康になる!2020

    • Author(s)
      能勢 博
    • Total Pages
      99
    • Publisher
      宝島社
    • ISBN
      9784299003065
    • Related Report
      2020 Annual Research Report
  • [Book] 10歳若返る 2テンポウォーキング2020

    • Author(s)
      能勢 博
    • Total Pages
      128
    • Publisher
      学研プラス
    • ISBN
      9784058011850
    • Related Report
      2020 Annual Research Report
  • [Book] 最高の歩き方2020

    • Author(s)
      能勢 博
    • Total Pages
      112
    • Publisher
      世界文化社
    • ISBN
      9784418204090
    • Related Report
      2020 Annual Research Report
  • [Book] 世界一効く 健康ウォーキング2020

    • Author(s)
      能勢 博
    • Total Pages
      144
    • Publisher
      池田書店
    • ISBN
      9784262165851
    • Related Report
      2020 Annual Research Report
  • [Book] 健康寿命が10歳延びる「筋トレ」ウォーキング 決定版2020

    • Author(s)
      能勢 博
    • Total Pages
      188
    • Publisher
      青春出版
    • ISBN
      9784413211642
    • Related Report
      2020 Annual Research Report
  • [Book] やさしい生理学(第7版)2019

    • Author(s)
      能勢 博
    • Publisher
      南江堂
    • ISBN
      9784524254170
    • Related Report
      2019 Annual Research Report
  • [Book] 標準生理学(第9版)2019

    • Author(s)
      能勢 博
    • Publisher
      医学書院
    • ISBN
      9784260034296
    • Related Report
      2019 Annual Research Report
  • [Book] ウォーキングの科学2019

    • Author(s)
      能勢 博
    • Publisher
      講談社
    • ISBN
      9784065176672
    • Related Report
      2019 Annual Research Report
  • [Book] Handbook Clinical Neurology vol 1562018

    • Author(s)
      Nose H, Kamijo Y, and Masuki S
    • Total Pages
      463
    • Publisher
      Elsevier
    • ISBN
      9780444639127
    • Related Report
      2018 Annual Research Report
  • [Remarks] 信州大学発「インターバル速歩」が米国生理学会の教科書に掲載されました!

    • URL

      https://www.shinshu-u.ac.jp/institution/ibs/topics/cat15432/comprehensive-physiology.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 信州大学発の「インターバル速歩」が、全米医学アカデミーのカタリストアワードを受賞!

    • URL

      https://www.shinshu-u.ac.jp/institution/ibs/topics/cat15432/post-39.html

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 運動開始前の情報に基づき最高酸素摂取量を求める方法および装置2020

    • Inventor(s)
      能勢 博、増木静江、真鍋憲正
    • Industrial Property Rights Holder
      能勢 博、増木静江、真鍋憲正
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2020-151297
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 被験者の運動を監視するシステム及び方法2020

    • Inventor(s)
      能勢 博、増木静江、降幡真由佳
    • Industrial Property Rights Holder
      能勢 博、増木静江、降幡真由佳
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-025136
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 運動開始前の情報に基づき最高酸素摂取量を求める方法および装置2019

    • Inventor(s)
      増木静江、真鍋憲正、能勢 博
    • Industrial Property Rights Holder
      増木静江、真鍋憲正、能勢 博
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-054242
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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