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Exploring biomarkers for early detection of sarcopenia and establishing new training evaluation techniques

Research Project

Project/Area Number 18H03164
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition

Principal Investigator

Yamada Yosuke  国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 特別研究員 (60550118)

Co-Investigator(Kenkyū-buntansha) 吉田 司  国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 身体活動研究部, 研究員 (20822175)
谷口 匡史  京都大学, 医学研究科, 助教 (00827701)
村木 重之  東京大学, 医学部附属病院, 届出研究員 (40401070)
近藤 衣美  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツ科学研究部, 契約研究員 (50515707)
横山 慶一  京都先端科学大学, 研究・連携支援センター, 客員研究員 (50774676)
川上 泰雄  早稲田大学, スポーツ科学学術院, 教授 (60234027)
吉村 典子  東京大学, 医学部附属病院, 特任教授 (60240355)
下山 寛之  筑波大学, 体育系, 助教 (80760652)
木村 みさか  京都先端科学大学, バイオ環境学部, 客員研究員 (90150573)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2018: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsサルコペニア / フレイル / 骨格筋 / 筋細胞量 / 診断基準 / 生体電気インピーダンス法 / 筋質 / ガイドライン / 筋力トレーニング / バイオマーカー / 身体機能 / 老化 / 生体電気インピーダンス / 分光法 / 筋内組成 / sarcopenia / 骨格筋量 / 早期発見
Outline of Final Research Achievements

The segmental bioelectrical impedance spectroscopy (S-BIS) method, which the principal investigators are developing, is capable of measuring not only the reduction in skeletal muscle cell mass and changes in intramuscular composition associated with sarcopenia, but also changes in the microenvironment inside and outside muscle cells and electrical properties of the muscle cell membrane due to exercise, which cannot be measured using MRI. S-BIS measured muscle capacitance (Cm) and characteristic frequency (fc) were related to surface EMG and contractile properties. This has made it possible to develop a new method of evaluation of training.

Academic Significance and Societal Importance of the Research Achievements

高齢者人口の急激な増加により、老化に伴う骨格筋量と骨格筋機能の低下が原因の寝たきりや要介護発生の人口も増加している。核磁気共鳴画像法(MRI)やX線CTあるいは二重X線エネルギー吸収法(DXA)などで筋量を評価することが行われているが、大型装置が必要で検査費用も高額なことから、一般的な介護施設や介護予防教室などの現場で汎用的に使用することは困難である。部位別生体電気インピーダンス分光(S-BIS)法は、サルコペニアに伴う骨格筋細胞量の低下や筋内組成の変化に加えて、MRIでは計測不可能である運動などによる筋細胞内外微小環境の変化や筋細胞膜の電気的性質の計測が可能で、臨床現場での応用可能性が高い。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report

Research Products

(19 results)

All 2022 2021 2020 2018 Other

All Int'l Joint Research (5 results) Journal Article (14 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 13 results,  Open Access: 8 results)

  • [Int'l Joint Research] ウィスコンシン大学マディソン校/カルフォルニア大学バークレー校(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] リスボン大学(ポルトガル)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ウィスコンシン大学マディソン校/カルフォルニア大学バークレー校(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ウィスコンシン大学マディソン校/カルフォルニア大学バークレー(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ウィスコンシン大学マディソン校/カルフォルニア大学バークレー校(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Effects of resistance training intensity on muscle quantity/quality in middle‐aged and older people: a randomized controlled trial2022

    • Author(s)
      Otsuka Yuta、Yamada Yosuke、Maeda Akifumi、Izumo Takayuki、Rogi Tomohiro、Shibata Hiroshi、Fukuda Masahiro、Arimitsu Takuma、Miyamoto Naokazu、Hashimoto Takeshi
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 13 Pages: 894-908

    • DOI

      10.1002/jcsm.12941

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-management processes, sedentary behavior, physical activity and dietary self-management behaviors: impact on muscle outcomes in continuing care retirement community residents2022

    • Author(s)
      Taani Murad H.、Strath Scott J.、Schiffman Rachel、Fendrich Michael、Harley Amy、Cho Chi C.、Yamada Yosuke、Kovach Christine R.
    • Journal Title

      BMC Geriatrics

      Volume: 22 Pages: 48-48

    • DOI

      10.1186/s12877-021-02691-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimating thigh skeletal muscle volume using multi-frequency segmental-bioelectrical impedance analysis2021

    • Author(s)
      Taniguchi Masashi、Yamada Yosuke、Yagi Masahide、Nakai Ryusuke、Tateuchi Hiroshige、Ichihashi Noriaki
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 40 Pages: 13-13

    • DOI

      10.1186/s40101-021-00263-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between habitual coffee consumption and skeletal muscle mass in middle‐aged and older Japanese people2021

    • Author(s)
      Iwasaka Chiharu、Yamada Yosuke、Nishida Yuichiro、Hara Megumi、Yasukata Jun、Miyoshi Nobuyuki、Shimanoe Chisato、Nanri Hinako、Furukawa Takuma、Koga Kayoko、Horita Mikako、Higaki Yasuki、Tanaka Keitaro
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 21 Pages: 950-958

    • DOI

      10.1111/ggi.14264

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination of DXA and BIS predicts jump power better than traditional measures of sarcopenia2021

    • Author(s)
      Rush Benjamin、Binkley Neil、Krueger Diane、Yamada Yosuke、Kuchnia Adam J
    • Journal Title

      JBMR Plus

      Volume: 5

    • DOI

      10.1002/jbm4.10527

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced echo intensity and a higher extracellular water-to-intracellular water ratio are helpful clinical signs for detecting muscle degeneration in patients with knee osteoarthritis2021

    • Author(s)
      Taniguchi Masashi、Fukumoto Yoshihiro、Yagi Masahide、Yamagata Momoko、Kobayashi Masashi、Yamada Yosuke、Kimura Misaka、Ichihashi Noriaki
    • Journal Title

      Clinical Rheumatology

      Volume: 40 Pages: 4207-4215

    • DOI

      10.1007/s10067-021-05763-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of bioelectrical phase angle with aerobic capacity, complex gait ability and total fitness score in older adults2021

    • Author(s)
      Yamada Yosuke、Itoi Aya、Yoshida Tsukasa、Nakagata Takashi、Yokoyama Keiichi、Fujita Hiroyuki、Kimura Misaka、Miyachi Motohiko
    • Journal Title

      Experimental Gerontology

      Volume: 150 Pages: 111350-111350

    • DOI

      10.1016/j.exger.2021.111350

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acute effect of multiple sets of fatiguing resistance exercise on muscle thickness, echo intensity, and extracellular-to-intracellular water ratio2020

    • Author(s)
      Masashi Taniguchi, Yosuke Yamada, Noriaki Ichihashi
    • Journal Title

      Applied Physiology, Nutrition, and Metabolism

      Volume: 45 Pages: 213-219

    • DOI

      10.1139/apnm-2018-0813

    • NAID

      120006975995

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive geriatric intervention in community‐dwelling older adults: a cluster‐randomized controlled trial2020

    • Author(s)
      Watanabe Yuya、Yamada Yosuke、Yoshida Tsukasa、Yokoyama Keiichi、Miyake Motoko、Yamagata Emi、Yamada Minoru、Yoshinaka Yasuko、Kimura Misaka、for Kyoto‐Kameoka Study Group
    • Journal Title

      The Journal of Cachexia, Sarcopenia and Muscle

      Volume: 11 Pages: 26-37

    • DOI

      10.1002/jcsm.12504

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle Mass, Quality, and Composition Changes During Atrophy and Sarcopenia2018

    • Author(s)
      Yamada Yosuke
    • Journal Title

      In J. Xiao ed. “Muscle Atrophy” (Series of “Advances in Experimental Medicine and Biology”) Springer Nature

      Volume: 1088 Pages: 47-72

    • DOI

      10.1007/978-981-13-1435-3_3

    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Journal Article] Combination of DXA and BIS body composition measurements is highly correlated with physical function-an approach to improve muscle mass assessment2018

    • Author(s)
      Kuchnia Adam J.、Yamada Yosuke、Teigen Levi、Krueger Diane、Binkley Neil、Schoeller Dale
    • Journal Title

      Archives of Osteoporosis

      Volume: 13

    • DOI

      10.1007/s11657-018-0508-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Could bioelectric impedance spectroscopy (BIS) measured appendicular intracellular water serve as a lean mass measurement in sarcopenia definitions? A pilot study2018

    • Author(s)
      Siglinsky E.、Buehring B.、Krueger D.、Binkley N.、Yamada Y.
    • Journal Title

      Osteoporosis International

      Volume: 29 Pages: 1653-1657

    • DOI

      10.1007/s00198-018-4475-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of Physical activity is with age-related changes in muscle echo intensity in older adults: a 4-years longitudinal study.2018

    • Author(s)
      Y Fukumoto, Y Yamada, T Ikezoe, Y Watanabe, M Taniguchi, S Sawano, S Minami, T Asai, M Kimura, N Ichihashi
    • Journal Title

      J Appl Physiol

      Volume: 125(5) Pages: 1468-1474

    • DOI

      10.1152/japplphysiol.00317.2018

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intracellular-to-total water ratio explains the variability of muscle strength dependence on the size of the lower leg in the elderly.2018

    • Author(s)
      Yoshida T, Y Yamada, Tanaka F, Yamagishi T, Shibata S, Kawakami Y
    • Journal Title

      Experimental Gerontology

      Volume: 113 Pages: 120-127

    • DOI

      10.1016/j.exger.2018.09.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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