| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Outline of Final Research Achievements |
Aging rate is regulated by environmental factors, such as oxidative stress. Because lung is the most important organ exposed to environmental agents, the degree of lung antioxidative activity is thought to be related to aging rate. Nrf2 is a transcription factor regulating the intracellular antioxidant responses. Nrf2 is expressed abundantly in the lung. In the present study, therefore, we investigate the protective effects of Nrf2 on the development of aging-related pulmonary infections. In both pneumococcal pneumonia and non-tuberculous mycobacterial pulmonary disease models in mice, survival rate after the infections was lower in elderly mice than in young mice. The degree of pulmonary inflammation and lung bacterial growth after the infections were higher in elderly mice than in young mice with less pulmonary activation of Nrf2. These results suggest that Nrf2 plays a protective role in the development of aging-related pulmonary infections.
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