| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Outline of Final Research Achievements |
Although there are many nutritional metabolites with preventive effects on lifestyle-related diseases, the molecular mechanism has yet to be elucidated. In this study, we aimed to identify new molecular target of orphan nutritional metabolites by utilizing our unique assay of transporter. We identified several nutritional metabolites that strongly inhibit a vesicular nucleotide transporter to control purinergic chemical transmission. The nutritional metabolites showed preventive and therapeutic effects on lifestyle-related diseases by selectively blocking the vesicular ATP release. We propose a new preventive care of diseases by blocking purinergic chemical transmission.
|
