| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2018: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Outline of Final Research Achievements |
Endurance exercise training and calorie restriction suppress the development of atherosclerosis. Considering that characteristic changes of skeletal muscle are involved in this mechanism, we focused on the transcription factors PGC-1α and FOXO-1 that cause the changes of muscles due to exercise and energy restriction. In this study, we focused on skeletal muscle-specific PGC-1α or FOXO-1 overexpression on the progression of atherosclerosis was investigated. As a result, overexpression of skeletal muscle-specific PGC-1α or FOXO-1 suppresses the progression of atherosclerosis. The physiology of bioactive substances secreted from skeletal muscle, such as β-aminoisobutyric acid and Irisin, might be involved in the suppression.
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