| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
The Alzheimer's dementia onset risk is higher in diabetic persons (DM) than non-diabetic persons, but the cause is unclear. Hypothesis: 1) A decrease in the interstitial fluid liquid pH in DM elevates the activity and expression of Aβ-producing enzymes, β and γ secretases, and diminishes Aβ-degrading enzyme, neprilysin, leading to Aβ accumulations in the brain of DM. 2) A weak acid, carboxylic acid, -containing food intake prevents elevation of blood sugar level and insulin resistance by improving the interstitial fluid pH. Purpose: To clarify the hypothesis mentioned above and choose the food improving the interstitial fluid pH. Result: A weak acid, carboxylic acid, -containing food intake elevated the interstitial fluid pH (improvement) and decreased (improved) accummulation of theAβ in the brain of DM.
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