The mechanism of motoric cognitive risk and dementia

• Project/Area Number: 18H03185
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: Doi Takehiko 国立研究開発法人国立長寿医療研究センター, 老年学・社会科学研究センター, 室長 (60589026)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000); Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2018: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
• Keywords: 歩行 / 認知機能 / 高齢者 / 認知症

Outline of Final Research Achievements

To investigate the mechanism of motoric cognitive risk syndrome as a risk factor for dementia, we investigated a multifaceted approach using biomarkers and brain imaging indices.　The results showed that motoric cognitive risk syndrome was associated with brain imaging indices, as well as biomarkers attributed to them, for a higher risk of dementia.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果より、motoric cognitive risk syndromeが血管性病変やアルツハイマー病理に関連する可能性が示唆された。そのため、それらの病理変化に対し検討されてきた介入方法の中から、どのような方法が適切かを精査し、motoric cognitive risk syndromeに対する介入を検討する必要があると考えられる。

Research Products

• [Journal Article] Cognitive Frailty as a Risk Factor for Incident Disability During Late Life: A 24-Month Follow-Up Longitudinal Study (2020)
  • Author(s): Tsutsumimoto K, Doi T, Nakakubo S, Kim M, Kurita S, Ishii H, Shimada H
  • Journal Title: J Nutr Health Aging Volume: 24 Issue: 5 Pages: 494-499
  • DOI: 10.1007/s12603-020-1365-9
  • Peer Reviewed
• [Journal Article] Physical Performance Predictors for Incident Dementia Among Japanese Community-Dwelling Older Adults (2019)
  • Author(s): Doi T, Tsutsumimoto K, Nakakubo S, Kim MJ, Kurita S, Hotta R, Shimada H.
  • Journal Title: Phys Ther Volume: 99 Issue: 9 Pages: 1132-1140
  • DOI: 10.1093/ptj/pzz077
  • Peer Reviewed
• [Journal Article] Rethinking the Relationship Between Spatiotemporal Gait Variables and Dementia: A Prospective Study (2019)
  • Author(s): Doi Takehiko、Tsutsumimoto Kota、Nakakubo Sho、Kim Min-Ji、Kurita Satoshi、Shimada Hiroyuki
  • Journal Title: Journal of the American Medical Directors Association Volume: 印刷中 Issue: 7 Pages: 899-903
  • DOI: 10.1016/j.jamda.2019.01.134
  • Peer Reviewed
• [Presentation] フレイル（身体的フレイル、社会的フレイル、認知機能低下）と死亡との関連－長期縦断観察研究－. (2020)
  • Author(s): 堤本広大, 土井剛彦, 中窪翔, 栗田智史, 石井秀明, 島田裕之.
  • Organizer: 第7回日本予防理学療法学会学術大会
• [Presentation] Motoric Cognitive Risk Syndrome は認知症発症リスクになりうるのか？ (2019)
  • Author(s): 土井剛彦, 堤本広大, 中窪翔, 金珉智, 栗田智史, 石井秀明, 島田裕之.
  • Organizer: 第9回日本認知症予防学会学術集会
• [Presentation] 認知症の発症と関連する歩行指標の検討 (2018)
  • Author(s): 土井剛彦, 堤本広大, 中窪翔, 牧野圭太郎, 牧迫飛雄馬, 島田裕之.
  • Organizer: 第5回日本予防理学療法学会学術大会