The role of the DMH in age-associated disturbance of sleep and body temperature
| Project/Area Number |
18H03186
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
Satoh Akiko 国立研究開発法人国立長寿医療研究センター, ジェロサイエンス研究センター, 副部長 (80800979)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 老化 / 視床下部 / 体温 / 睡眠 / 脳 / 入眠時体温調節 / 入眠障害 / 体温調節 / 入眠潜時 / 睡眠制限 / 睡眠恒常性 / 体温制御 |
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| Outline of Final Research Achievements |
In this study, we addressed whether reduction of Prdm13 function in the dorsomedial hypothalamus causes a deficit in thermoregulation before sleep onset, resulting in sleep problems. Mouse studies using old mice, dietary restricted mice, and dorsomedial hypothalamic-specific Prdm13-knockout mice revealed that changes in body temperature at the onset of sleep is highly correlated with changes in sleep regulatory network. We also observed there is a sexual dimorphism in this regulation.
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| Academic Significance and Societal Importance of the Research Achievements |
睡眠と体温の調節には密接な関係があるが、老化過程におけるこれらの機能変化とそのメカニズムは不明である。本研究から老化寿命を制御しうる新規視床下部神経が睡眠調節に伴う体温調節に関与することが明らかにされ,、体温調節と老化制御をつなぐ鍵となる制御系が見出された。
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Report
(5 results)
Research Products
(29 results)
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[Presentation] PRDM13-positive neurons regulate age-associated pathophysiology, and longevity through sleep homeostasis in mammals2021
Author(s)
Shogo Tsuji, Cynthia S. Brace, Ruiqing Yao, Yoshitaka Tanie, Nicholas Rensing, Seiya Mizuno, Kazuhiro Nakamura, Satoru Takahashi, Michael Wong, Shin-ichiro Imai, Akiko Satoh
Organizer
Cold Spring Harbor meeting: Mechanisms of Aging
Related Report
Int'l Joint Research
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