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Investigation of gene-environment interaction associated with salt intake and onset/progression of type 2 diabetes mellitus

Research Project

Project/Area Number 18H03188
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionYamagata University

Principal Investigator

Togashi Hitoshi  山形大学, 保健管理センター, 教授 (60192209)

Co-Investigator(Kenkyū-buntansha) 嘉山 孝正  山形大学, 医学部, 名誉教授 (50142972)
山下 英俊  山形大学, 医学部, 教授 (90158163)
玉手 英利  山形大学, 学内共同利用施設等, 学長 (90163675)
上野 義之  山形大学, 医学部, 教授 (70282126)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Keywordsコホート研究 / 糖尿病 / 高血圧 / 塩分摂取 / ネットワーク解析 / 食事嗜好性 / 塩分ストレス / ゲノムコホート研究 / 遺伝環境相互作用 / 食餌嗜好性 / 発がん / ネットワーク分析 / 食餌嗜好
Outline of Final Research Achievements

Salt stress is thought to be a risk factor for the development and progression of diabetes. However, it is unclear what factors, including genetic information, lead to the development and progression of diabetes. We attempted to elucidate the factors associated with excessive salt intake and the development of diabetes using a cohort study in Yamagata Prefecture. As salt intake increased, blood pressure, BMI, and the incidence of diabetes increased. The results of the questionnaire showed that awareness of salt reduction did not lead to a decrease in salt intake. The network analysis was extremely useful for analyzing multiple factors, and clearly showed that the low-salt intake group had a dietary preference to consume multiple vegetables.

Academic Significance and Societal Importance of the Research Achievements

私どもは、塩分過剰摂取と糖尿病の関連性について地域住民を対象として明瞭に示すことが出来た。重要な点は高塩分摂取群で男女とも減塩意識をしている比率が高いにも関わらず、必ずしも減塩につながっていないことが明らかになった。WHOが提唱する減塩目標に達成するためには、適切な減塩指導が必要であり地域における健康支援計画に貢献すると考えられた。食事習慣をネットワーク解析により視覚化し、その意義を検討した報告は本研究が初めてであり、疾病予防の確立になり得ると考えられた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (25 results)

All 2021 2020 2019 2018

All Journal Article (23 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 22 results,  Open Access: 6 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] High Parity Is an Independent Risk Factor for Tooth Loss in Women: A Community-Based Takahata Study in Japan2021

    • Author(s)
      Ishikawa Shigeo、Konta Tsuneo、Susa Shinji、Edamatsu Kaoru、Ishizawa Kenichi、Togashi Hitoshi、Nagase Satoru、Ueno Yoshiyuki、Kubota Isao、Yamashita Hidetoshi、Kayama Takamasa、Iino Mitsuyoshi
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 253 Issue: 1 Pages: 77-84

    • DOI

      10.1620/tjem.253.77

    • NAID

      130007975527

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Associations of Frequency of Laughter With Risk of All-Cause Mortality and Cardiovascular Disease Incidence in a General Population: Findings From the Yamagata Study2020

    • Author(s)
      Sakurada Kaori、Konta Tsuneo、Watanabe Masafumi、Ishizawa Kenichi、Ueno Yoshiyuki、Yamashita Hidetoshi、Kayama Takamasa
    • Journal Title

      Journal of Epidemiology

      Volume: 30 Issue: 4 Pages: 188-193

    • DOI

      10.2188/jea.JE20180249

    • NAID

      130007828829

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2020-04-05
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo analysis of redox status in organs ? from bench to bedside2020

    • Author(s)
      Uchida Tetsuro、Togashi Hitoshi、Kuroda Yoshinori、Yamashita Atsushi、Itoh Nanami、Haga Kazuyuki、Sadahiro Mitsuaki、Kayama Takamasa
    • Journal Title

      Free Radical Research

      Volume: - Issue: 11-12 Pages: 1-8

    • DOI

      10.1080/10715762.2020.1772470

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress evaluation of skeletal muscle in ischemia?reperfusion injury using enhanced magnetic resonance imaging2020

    • Author(s)
      Kuroda Yoshinori、Togashi Hitoshi、Uchida Tetsuro、Haga Kazuyuki、Yamashita Atsushi、Sadahiro Mitsuaki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-67336-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between presence of 20 or more natural teeth and all-cause, cancer-related, and cardiovascular disease-related mortality: Yamagata (Takahata) prospective observational study2020

    • Author(s)
      Ishikawa Shigeo、Konta Tsuneo、Susa Shinji、Ishizawa Kenichi、Togashi Hitoshi、Ueno Yoshiyuki、Yamashita Hidetoshi、Kayama Takamasa、Iino Mitsuyoshi
    • Journal Title

      BMC Oral Health

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12903-020-01346-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between social support status and mortality in a community-based population: a prospective observational study (Yamagata study)2020

    • Author(s)
      Uzuki Tsutomu、Konta Tsuneo、Saito Ritsuko、Sho Ri、Osaki Tsukasa、Souri Masayoshi、Watanabe Masafumi、Ishizawa Kenichi、Yamashita Hidetoshi、Ueno Yoshiyuki、Kayama Takamasa
    • Journal Title

      BMC Public Health

      Volume: 20 Issue: 1

    • DOI

      10.1186/s12889-020-09752-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association among chronic kidney disease, airflow limitation, and mortality in a community-based population: The Yamagata (Takahata) study.2020

    • Author(s)
      Suzuki N, Matsuki E, Araumi A, Ashitomi S, Watanabe S, Kudo K, Ichikawa K, Inoue S, Watanabe M, Ueno Y, Ishizawa K, Kayama T, Konta T.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 5570-5570

    • DOI

      10.1038/s41598-020-62540-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] UPI調査結果の新たな解析の試み.2020

    • Author(s)
      伊藤ななみ、冨樫 整、他.
    • Journal Title

      CAMPUS HEALTH

      Volume: 57 Pages: 359-361

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Risk factors for tooth loss in community-dwelling Japanese aged 40 years and older: the Yamagata (Takahata) study.2019

    • Author(s)
      Ishikawa S, Togashi H, Iino M, et al.
    • Journal Title

      Clin Oral Investig.

      Volume: 23 Issue: 3 Pages: 1753-1560

    • DOI

      10.1111/idh.12374

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between genotypes of urate transporter-1, serum uric acid, and mortality in the community-based population: the Yamagata (Takahata) Study.2019

    • Author(s)
      Kon S, Kayama T, et al.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 23 Issue: 12 Pages: 1357-1363

    • DOI

      10.1007/s10157-019-01781-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rupture risk of small unruptured cerebral aneurysms2019

    • Author(s)
      Ikawa Fusao、Morita Akio、Tominari Shinjiro、Nakayama Takeo、Shiokawa Yoshiaki、Date Isao、Nozaki Kazuhiko、Miyamoto Susumu、Kayama Takamasa、Arai Hajime
    • Journal Title

      Journal of Neurosurgery

      Volume: Epub Issue: 1 Pages: 1-10

    • DOI

      10.3171/2018.9.jns181736

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficiency score from data envelopment analysis can predict the future onset of hypertension and dyslipidemia: A cohort study2019

    • Author(s)
      Nakamura S, Narimatsu H, Nakata Y, Sakaguchi M, Konta T, Watanabe M, Ueno Y, Ishizawa K, Yamashita H, Kayama T, Yoshioka T.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 16309-16309

    • DOI

      10.1038/s41598-019-52898-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence and causes of visual impairment in Japan: the first nation-wide complete enumeration survey of newly certified visually impaired indivisuals.2019

    • Author(s)
      Morizane Y, Yamashita H, et al.
    • Journal Title

      Jpn J Ophthalmol.

      Volume: 63 Issue: 1 Pages: 26-33

    • DOI

      10.1007/s10384-018-0623-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diabetes care providers' manual for disaster diabetes care.2019

    • Author(s)
      Satoh J et al.
    • Journal Title

      Diabetol Int.

      Volume: 10 Issue: 3 Pages: 153-179

    • DOI

      10.1007/s13340-019-00397-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide study on genetic diversity and phylogeny of five species in the genus Cervus.2019

    • Author(s)
      Hu P, Tamate H, et al.
    • Journal Title

      BMC Genomics.

      Volume: 20 Issue: 1 Pages: 384-384

    • DOI

      10.1186/s12864-019-5785-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mating of escaped domestic pigs with wild boar and possibility of their offspring migration after the Fukushima Daiichi Nuclear Power Plant accident.2019

    • Author(s)
      Anderson D, Toma R, Negishi Y, Okuda K, Ishiniwa H, Hinton TG, Namba K, Tamate HB, Kaneko S
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-6

    • DOI

      10.1038/s41598-019-47982-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of introgressive hybridization among Cervidae in Japan’s Kinki District via two novel genetic markers developed from public NGS data2019

    • Author(s)
      Matsumoto Y, Takagi T, Koda R, Tanave A, Yamashiro A, Tamate HB
    • Journal Title

      Ecology and Evolution

      Volume: ECE35131 Issue: 10 Pages: 5605-5616

    • DOI

      10.1002/ece3.5131

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] <i>In vivo</i> visualization of redox status by high-resolution whole body magnetic resonance imaging using nitroxide radicals2018

    • Author(s)
      Uchida T, Togashi H, et al
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 63 Issue: 3 Pages: 192-196

    • DOI

      10.3164/jcbn.18-18

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Presence of Myocardial Damage Predicts Future Development of Hypertension in a Normotensive Japanese General Population: The Yamagata (Takahata) Study.2018

    • Author(s)
      Honda Y, Kayama T, et al.
    • Journal Title

      Am J Hypertens.

      Volume: 31 Issue: 5 Pages: 549-556

    • DOI

      10.1093/ajh/hpy008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ventricular wall stress and silent myocardial damage are associated with pulse pressure in the general population.2018

    • Author(s)
      Takahashi T, Shishido T, Watanabe K, Sugai T, Toshima T, Kinoshita D, Yokoyama M, Tamura H, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Shibata Y, Konta T, Ueno Y, Kato T, Kayama T, Kubota I, Watanabe M.
    • Journal Title

      J Clin Hypertens (Greenwich).

      Volume: 33 Issue: 9 Pages: 1319-1326

    • DOI

      10.1111/jch.13349

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of surgery with salvage stereotactic radiosurgery versus surgery with whole-brain radiation therapy in patients with one to four brain metastases (JCOG0504): A Phase III, noninferiority, randomized controlled trial2018

    • Author(s)
      Kayama Takamasa、Sato Shinya、Sakurada Kaori、et al
    • Journal Title

      Journal of Clinical Oncology

      Volume: 36 Issue: 33 Pages: 3282

    • DOI

      10.1200/jco.2018.78.6186

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Small-molecule Kinase Inhibitor, CEP-1347, Inhibits Survivin Expression and Sensitizes Ovarian Cancer Stem Cells to Paclitaxel.2018

    • Author(s)
      Togashi K, Okada M, Yamamoto M, Suzuki S, Sanomachi T, Seino S, Yamashita H, Kitanaka C.
    • Journal Title

      Anticancer Res.

      Volume: 38 Issue: 8 Pages: 4535-4542

    • DOI

      10.21873/anticanres.12757

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Age-related variations in corneal geometry and their association with astigmatism: The Yamagata Study (Funagata).2018

    • Author(s)
      Namba H, Yamashita H, et al.
    • Journal Title

      Medicine (Baltimore).

      Volume: 97 Issue: 43 Pages: e12894-e12894

    • DOI

      10.1097/md.0000000000012894

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] UPI調査結果による精神的健康と身体的健康との関連の検討2020

    • Author(s)
      伊藤ななみ,冨樫 整,他
    • Organizer
      第58回全国大学保健管理研究集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of asialoglycoprotein receptors in the right and left hepatic lobes using Tc-GSA SPECT.2018

    • Author(s)
      Togashi H
    • Organizer
      13th IHPBA World Congress, Geneva
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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