Establishment of method for ameliorating social jet lag by chrono-nutrition and chrono-exercise

• Project/Area Number: 18H03198
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Waseda University
• Principal Investigator: Higuchi Mitsuru 早稲田大学, スポーツ科学学術院, 名誉教授 (20192289)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2021: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2019: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 社会的時差ボケ / 時間栄養学 / 時間運動学 / 生体リズム / 動脈スティフネス / モーニングサージ / 睡眠 / 生活リズム / 概日リズム / 時計遺伝子 / 早朝血圧 / 時間栄養・運動学 / 代謝異常

Outline of Final Research Achievements

The present study conducted an observational study of middle-aged and elderly adults and an interventional study of young adults to elucidate the association of chronic and acute social jetlag (SJL) with cardiometabolic risk in Japanese. The results of the observational study suggest that chronic SJL is associated with obesity indices including BMI and waist circumference independently of sleep duration and chronotype. Furthermore, the results of the interventional study suggest that acute SJL increases central arterial stiffness and arguments morning blood pressure surge in Japanese.

Academic Significance and Societal Importance of the Research Achievements

日本は世界で最も労働時間が長い国家の一つであり、勤労者は平日に十分な睡眠時間を確保しづらい状況にある。したがって、日本人を対象として慢性的および一過性の社会的時差ボケの健康影響を明らかにすることの社会的意義は大きい。

Research Products

• [Journal Article] No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging (2023)
  • Author(s): Seki Y, Aczel D, Torma F, Jokai M, Boros A, Suzuki K, Higuchi M, Tanisawa K, Boldogh I, Horvath S, Radak Z
  • Journal Title: Biogerontology Volume: 24(2) Issue: 2 Pages: 245-255
  • DOI: 10.1007/s10522-022-10011-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fat-Free Mass Index as a Surrogate Marker of Appendicular Skeletal Muscle Mass Index for Low Muscle Mass Screening in Sarcopenia (2022)
  • Author(s): Kawakami Ryoko、Tanisawa Kumpei、Ito Tomoko、Usui Chiyoko、Miyachi Motohiko、Torii Suguru、Midorikawa Taishi、Ishii Kaori、Muraoka Isao、Suzuki Katsuhiko、Sakamoto Shizuo、Higuchi Mitsuru、Oka Koichiro
  • Journal Title: Journal of the American Medical Directors Association Volume: 23 Issue: 12 Pages: 1955-1961
  • DOI: 10.1016/j.jamda.2022.08.016
  • Peer Reviewed / Open Access
• [Journal Article] Coffee consumption and skeletal muscle mass: WASEDA’S Health Study (2022)
  • Author(s): Kawakami Ryoko、Tanisawa Kumpei、Ito Tomoko、Usui Chiyoko、Ishii Kaori、Muraoka Isao、Suzuki Katsuhiko、Sakamoto Shizuo、Higuchi Mitsuru、Oka Koichiro
  • Journal Title: British Journal of Nutrition Volume: - Issue: 1 Pages: 1-10
  • DOI: 10.1017/s0007114522003099
  • Peer Reviewed / Open Access
• [Journal Article] The combination of cardiorespiratory fitness and muscular fitness, and prevalence of diabetes mellitus in middle-aged and older men: WASEDA'S Health Study (2022)
  • Author(s): Wang D, Sawada SS, Tabata H, Kawakami R, Ito T, Tanisawa K, Higuchi M, Ishii K, Oka K, Suzuki K, Sakamoto S
  • Journal Title: BMC Public Health Volume: 22(1) Issue: 1 Pages: 626-626
  • DOI: 10.1186/s12889-022-12971-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association Between Dietary Patterns and Different Metabolic Phenotypes in Japanese Adults: WASEDA'S Health Study (2021)
  • Author(s): Tanisawa K, Ito T, Kawakami R, Usui C, Kawamura T, Suzuki K, Sakamoto S, Ishii K, Muraoka I, Oka K, Higuchi M
  • Journal Title: Clin Nutr Volume: 40(11) Issue: 11 Pages: 5523-5530
  • DOI: 10.1016/j.clnu.2021.09.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between alcohol dietary pattern and prevalence of dyslipidaemia: WASEDA'S Health Study (2021)
  • Author(s): Tanisawa K, Ito T, Kawakami R, Usui C, Kawamura T, Suzuki K, Sakamoto S, Ishii K, Muraoka I, Oka K, Higuchi M
  • Journal Title: Br J Nutr Volume: - Issue: 11 Pages: 1712-1722
  • DOI: 10.1017/s0007114521002671
  • Peer Reviewed / Open Access
• [Journal Article] Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study (2021)
  • Author(s): Kawamura T, Tanisawa K, Kawakami R, Usui C, Ito T, Tabata H, Nakamura N, Kurosawa S, Choi W, Ma S, Radak Z, Sawada SS, Suzuki K, Ishii K, Sakamoto S, Oka K, Higuchi M, Muraoka I
  • Journal Title: Oxid Med Cell Longev Volume: - Issue: 1 Pages: 5566880-5566880
  • DOI: 10.1155/2021/5566880
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Greater arterial wall viscosity in endurance-trained men (2021)
  • Author(s): Kawano H, Asaka M, Yamamoto K, Gando Y, Konishi M, Sakamoto S, Miyachi M, Higuchi M
  • Journal Title: Eur J Appl Physiol Volume: 121(8) Pages: 2219-2228
  • DOI: 10.1007/s00421-021-04686-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Response to the Letter to the Editor Regarding "Effect of Vitamin D Supplementation on Body Composition and Physical Fitness in Healthy Adults: A Double-Blind, Randomized Controlled Trial" (2020)
  • Author(s): Sun X, Tanisawa K, Zhang Y, Ito T, Oshima S, Higuchi M, Cao ZB
  • Journal Title: Ann Nutr Metab Volume: in press Issue: 1 Pages: 87-87
  • DOI: 10.1159/000507106
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anti-Osteoporotic Effect of Soy Isoflavones Intake on Low Bone Mineral Density Caused by Voluntary Exercise and Food Restriction in Mature Female Rats (2019)
  • Author(s): Yanaka K, Higuchi M, Ishimi Y
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 65 Issue: 4 Pages: 335-342
  • DOI: 10.3177/jnsv.65.335
  • NAID: 130007697546
  • ISSN: 0301-4800, 1881-7742
  • Year and Date: 2019-08-31
  • Peer Reviewed / Open Access
• [Journal Article] Micronutrient Intake Adequacy in Men and Women with a Healthy Japanese Dietary Pattern (2019)
  • Author(s): Ito T, Tanisawa K, Kawakami R, Usui C, Ishii K, Suzuki K, Sakamoto S, Muraoka I, Oka K, Higuchi M
  • Journal Title: Nutrients Volume: 12(1) Issue: 1 Pages: 6-6
  • DOI: 10.3390/nu12010006
  • Peer Reviewed / Open Access
• [Journal Article] Sun X, Tanisawa K, Zhang Y, Ito T, Oshima S, Higuchi M, Cao ZB. Effect of Vitamin D Supplementation on Body Composition and Physical Fitness in Healthy Adults: A Double-Blind, Randomized Controlled Trial (2019)
  • Author(s): Sun X, Tanisawa K, Zhang Y, Ito T, Oshima S, Higuchi M, Cao ZB
  • Journal Title: Ann Nutr Metab Volume: in press Issue: 4 Pages: 231-237
  • DOI: 10.1159/000504873
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association of day-to-day variations in physical activity with postprandial appetite regulation in lean young males (2019)
  • Author(s): Ando T、Higuchi M、Tanaka S
  • Journal Title: Nutrients Volume: 11 Issue: 10 Pages: 2267-2267
  • DOI: 10.3390/nu11102267
  • Peer Reviewed / Open Access
• [Journal Article] Ageing affects the association between serum 25- hydroxyvitamin D concentrations and cardiorespiratory fitness in middle-aged and elderly men (2019)
  • Author(s): Sun X, Tanisawa K, Ito T, Oshima S, Higuchi M, Cao ZB
  • Journal Title: Asia Pac J Clin Nutr Volume: 28(3) Pages: 614-620
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of watching professional baseball at a stadium on health-related outcomes among Japanese older adults: A randomized controlled trial (2019)
  • Author(s): Kawakami Ryoko、Sawada S Susumu、Ito Tomoko、Gando Yuko、Fukushi Tomohiro、Yoshino Atsushi、Kurita Satoshi、Oka Koichiro、Sakamoto Shizuo、Higuchi Mitsuru
  • Journal Title: Geriatr Gerontol Int Volume: 印刷中 Issue: 8 Pages: 717-722
  • DOI: 10.1111/ggi.13687
  • Peer Reviewed / Open Access
• [Journal Article] Leisure-time physical activity and DNA damage among Japanese workers (2019)
  • Author(s): Kawakami Ryoko、Kashino Ikuko、Kasai Hiroshi、Kawai Kazuaki、Li Yun-Shan、Nanri Akiko、Higuchi Mitsuru、Mizoue Tetsuya
  • Journal Title: PLOS ONE Volume: 14 Issue: 2 Pages: e0212499-e0212499
  • DOI: 10.1371/journal.pone.0212499
  • Peer Reviewed / Open Access
• [Journal Article] Association of Serum 25-Hydroxyvitamin D Concentrations With Glucose Profiles in Male Collegiate Football Athletes (2019)
  • Author(s): Sun X, Cao ZB, Tanisawa K, Oshima S, Higuchi M
  • Journal Title: Int J Sport Nutr Exerc Metab Volume: 26 Issue: 4 Pages: 1-6
  • DOI: 10.1123/ijsnem.2018-0225
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Exercise and probiotics attenuate the development of Alzheimer's disease in transgenic mice: Role of microbiome (2019)
  • Author(s): Abraham D, Feher J, Scuderi GL, Szabo D, Dobolyi A, Cservenak M, Juhasz J, Ligeti B, Pongor S, Gomez-Cabrera MC, Vina J, Higuchi M, Suzuki K, Boldogh I, Radak Z
  • Journal Title: Exp Gerontol Volume: 115 Pages: 122-131
  • DOI: 10.1016/j.exger.2018.12.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dietary patterns and abdominal obesity in middle-aged and elderly Japanese adults: Waseda Alumni's Sports, Exercise, Daily Activity, Sedentariness and Health Study (WASEDA'S Health Study) (2019)
  • Author(s): Ito T, Kawakami R, Tanisawa K, Miyawaki R, Ishii K, Torii S, Suzuki K, Sakamoto S, Muraoka I, Oka K, Higuchi M; WASEDA'S Health Study Group
  • Journal Title: Nutrition Volume: 58 Pages: 149-155
  • DOI: 10.1016/j.nut.2018.05.029
  • Peer Reviewed / Open Access
• [Journal Article] Exercise Effects on Physiological Function during Aging. (2019)
  • Author(s): Z Radak, F Torma, I Berkes, S Goto, T Mimura, A Posa, L Balogh,K Suzuki et al.
  • Journal Title: Free Radical Biology and Medicine Volume: 132 Pages: 33-4
  • DOI: 10.1016/j.freeradbiomed.2018.10.444
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Preexercise Carbohydrate Ingestion and Transient Hypoglycemia (2019)
  • Author(s): S. Kondo, K. Tanisawa, K. Suzuki, S. Terada, M. Higuchi
  • Journal Title: Fasting vs. Feeding. Med Sci Sports Exerc Volume: 51(1) Issue: 1 Pages: 168-168
  • DOI: 10.1249/mss.0000000000001773
  • Peer Reviewed / Open Access
• [Journal Article] Effects of short-term endurance exercise on gut microbiota in elderly men (2018)
  • Author(s): Taniguchi H, Tanisawa K, Sun X, Kubo T, Hoshino Y, Hosokawa M, Takeyama H, Higuchi M
  • Journal Title: Physiol Rep Volume: 6(23) Issue: 23 Pages: e13935-e13935
  • DOI: 10.14814/phy2.13935
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of Different Loads on Force-Time Characteristics during Back Squats (2018)
  • Author(s): Kubo T, Hirayama K, Nakamura N, Higuchi M
  • Journal Title: J Sports Sci Med Volume: 17(4) Pages: 617-622
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Accommodating Elastic Bands on Mechanical Power Output during Back Squats (2018)
  • Author(s): Takafumi Kubo, Kuniaki Hirayama, Nobuhiro Nakamura, Mitsuru Higuchi
  • Journal Title: Sports Volume: 6 Issue: 4 Pages: 151-151
  • DOI: 10.3390/sports6040151
  • Peer Reviewed / Open Access
• [Journal Article] Serum 25-Hydroxyvitamin D Concentrations Are Inversely Correlated with Hepatic Lipid Content in Male Collegiate Football Athletes (2018)
  • Author(s): Sun X, Cao ZB, Tanisawa K, Oshima S, Higuchi M
  • Journal Title: Nutrients Volume: 10(7) Issue: 7 Pages: 942-942
  • DOI: 10.3390/nu10070942
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Time Course of Decrease in Skeletal Muscle Mitochondrial Biogenesis after Discontinuation of High-Fat Diet (2018)
  • Author(s): Li X, Higashida K, Kawamura T, Higuchi M
  • Journal Title: Journal of Nutritional Science and Vitaminology Volume: 64 Issue: 3 Pages: 233-238
  • DOI: 10.3177/jnsv.64.233
  • NAID: 130007413184
  • ISSN: 0301-4800, 1881-7742
  • Peer Reviewed / Open Access
• [Presentation] Exercise and dietary lifestyle for senior health (2018)
  • Author(s): Higuchi M
  • Organizer: MIRAI Workshop
  • Int'l Joint Research / Invited
• [Presentation] Dietary Pattern and Physical Activity for Senior Health -WASEDA'S Health Study- (2018)
  • Author(s): Higuchi M
  • Organizer: Taiwan society for sports nutrition Annual Symposium
  • Int'l Joint Research / Invited
• [Book] 体力の正体は筋肉 (2018)
  • Author(s): 樋口 満
  • Total Pages: 192
  • Publisher: 集英社
  • ISBN: 9784087210309
• [Book] 栄養・スポーツ系の運動生理学 (2018)
  • Author(s): 樋口 満 (監修), 湊 久美子 (編集), 寺田 新 (編集)
  • Total Pages: 208
  • Publisher: 南江堂
  • ISBN: 9784524237975
• [Book] トレーニングのための生理学的知識 (2018)
  • Author(s): Zsolt Radak (著), 樋口 満 (監訳)
  • Total Pages: 195
  • Publisher: 市村出版
  • ISBN: 9784902109504