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Elucidation of human brain metabolism to maintain/improve higher-order brain function and development of exercise and nutritional prescription

Research Project

Project/Area Number 18H03200
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionRitsumeikan University

Principal Investigator

Hashimoto Takeshi  立命館大学, スポーツ健康科学部, 教授 (70511608)

Co-Investigator(Kenkyū-buntansha) 小河 繁彦  東洋大学, 理工学部, 教授 (80553841)
家光 素行  立命館大学, スポーツ健康科学部, 教授 (90375460)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords脳機能 / 認知症 / 高強度間欠的運動 / 乳酸 / 認知機能 / 脳内代謝 / 運動 / 栄養 / 代謝 / 脳循環 / 実行機能 / レジスタンス運動 / 中高齢者 / 栄養素 / 安定同位体 / 認知実行機能 / 動静脈較差 / メタボローム / 脳代謝
Outline of Final Research Achievements

By obtaining blood samples from the right internal jugular venous bulb and from the brachial artery to determine differences across the brain for lactate, glucose, oxygen, and brain-derived neurotrophic factor (BDNF), we assessed whether exercise-induced enhancement of executive function (EF) relates to brain lactate uptake.
We propose that improved EF after exercise relates to cerebral lactate metabolism and is thereby linked to systemic metabolism as an example of the “Lactate Shuttle” mechanism (i.e., muscle contraction-induced lactate can be an important energy substrate to maintain/improve brain function). Furthermore, we assessed the effects of various exercise modalities on cognitive function.

Academic Significance and Societal Importance of the Research Achievements

脳内乳酸代謝が認知機能亢進に及ぼす影響や運動・栄養処方による脳機能応答の詳細を、ヒトにおいて生理・生化学的に明らかにできた。すなわち、脳機能亢進や認知症予防に極めて重要かつ独創的な機序(乳酸)の解明を達成した。加えて、様々な運動様式が認知機能に及ぼす影響を評価し、効果的・効率的に認知機能亢進を招来する運動処方を明らかにした。このことは、適切な実践的応用(運動・栄養処方)方略策定の学術的基盤創出に貢献するものである。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (44 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (12 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 12 results,  Open Access: 9 results) Presentation (27 results) (of which Int'l Joint Research: 15 results,  Invited: 6 results) Book (2 results)

  • [Int'l Joint Research] University of Copenhagen(デンマーク)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Texas(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University Hospital Tubingen(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Impact of Inter-Set Short Rest Interval Length on Inhibitory Control Improvements Following Low-Intensity Resistance Exercise in Healthy Young Males2021

    • Author(s)
      Tomoo Keigo、Suga Tadashi、Dora Kento、Sugimoto Takeshi、Mok Ernest、Tsukamoto Hayato、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
    • Journal Title

      Frontiers in Physiology

      Volume: 12 Pages: 741966-741966

    • DOI

      10.3389/fphys.2021.741966

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exercise adherence‐related perceptual responses to low‐load blood flow restriction resistance exercise in young adults: A pilot study2021

    • Author(s)
      Suga Tadashi、Dora Kento、Mok Ernest、Sugimoto Takeshi、Tomoo Keigo、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 23

    • DOI

      10.14814/phy2.15122

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Exercise on Brain Health: The Potential Role of Lactate as a Myokine2021

    • Author(s)
      Hashimoto Takeshi、Tsukamoto Hayato、Ando Soichi、Ogoh Shigehiko
    • Journal Title

      Metabolites

      Volume: 11 Issue: 12 Pages: 813-813

    • DOI

      10.3390/metabo11120813

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated respiratory chemoreflex‐mediated regulation of cerebral blood flow in hypoxia: Implications for oxygen delivery and acute mountain sickness2021

    • Author(s)
      Ogoh Shigehiko、Washio Takuro、Stacey Benjamin S.、Tsukamoto Hayato、Iannetelli Angelo、Owens Thomas S.、Calverley Thomas A.、Fall Lewis、Marley Christopher J.、Saito Shotaro、Watanabe Hironori、Hashimoto Takeshi、Ando Soichi、Miyamoto Tadayoshi、Bailey Damian M.
    • Journal Title

      Experimental Physiology

      Volume: 106 Issue: 9 Pages: 1922-1938

    • DOI

      10.1113/ep089660

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of very low-intensity resistance exercise with slow movement and tonic force generation on post-exercise inhibitory control2021

    • Author(s)
      Kento Dora, Tadashi Suga, Keigo Tomoo, Takeshi Sugimoto, Ernest Mok, Hayato Tsukamoto, Shingo Takada, Takeshi Hashimoto, Tadao Isak
    • Journal Title

      Heliyon

      Volume: 7 Issue: 2 Pages: e06261-e06261

    • DOI

      10.1016/j.heliyon.2021.e06261

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Similar improvements in cognitive inhibitory control following low-intensity resistance exercise with slow movement and tonic force generation and high-intensity resistance exercise in healthy young adults: a preliminary study2021

    • Author(s)
      Dora Kento、Suga Tadashi、Tomoo Keigo、Sugimoto Takeshi、Mok Ernest、Tsukamoto Hayato、Takada Shingo、Hashimoto Takeshi、Isaka Tadao
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 71 Issue: 1 Pages: 1-12

    • DOI

      10.1186/s12576-021-00806-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Greater increase in internal carotid artery shear rate during aerobic interval compared to continuous exercise in healthy adult men2021

    • Author(s)
      Ogoh Shigehiko、Washio Takuro、Suzuki Kazuya、Iemitsu Motoyuki、Hashimoto Takeshi、Iwamoto Erika、Bailey Damian M.
    • Journal Title

      Physiological Reports

      Volume: 9 Issue: 2

    • DOI

      10.14814/phy2.14705

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acute effect of the timing of resistance exercise and nutrient intake on muscle protein breakdown2020

    • Author(s)
      Kume W, Yasuda J, Hashimoto T
    • Journal Title

      Nutrients

      Volume: 12(4) Issue: 4 Pages: 1177-1177

    • DOI

      10.3390/nu12041177

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does exercise improve false episodic memory in dementia?2019

    • Author(s)
      Ogoh S, Hashimoto T, Ando S
    • Journal Title

      Journal of Clinical Medicine

      Volume: 8(11) Issue: 11 Pages: 1829-1829

    • DOI

      10.3390/jcm8111829

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle Stiffness of the Vastus Lateralis in Sprinters and Long-Distance Runners2019

    • Author(s)
      MIYAMOTO NAOKAZU、HIRATA KOSUKE、INOUE KAKERU、HASHIMOTO TAKESHI
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 51 Issue: 10 Pages: 2080-2087

    • DOI

      10.1249/mss.0000000000002024

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Cerebral Autoregulation Is Maintained during High-Intensity Interval Exercise.2019

    • Author(s)
      Tsukamoto H, Hashimoto T, Olesen ND, Petersen LG, Sorensen H, Nielsen HB, Secher NH, Ogoh S.
    • Journal Title

      Med Sci Sports Exerc.

      Volume: Feb;51(2) Issue: 2 Pages: 372-378

    • DOI

      10.1249/mss.0000000000001792

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self-selected music-induced reduction of perceived exertion during moderate-intensity exercise does not interfere with post-exercise improvements in inhibitory control2018

    • Author(s)
      Tanaka D, Tsukamoto H, Suga T, Takenaka S, Hamaoka T, Hashimoto T, Isaka T
    • Journal Title

      Physiology and Behavior

      Volume: 194 Pages: 170-176

    • DOI

      10.1016/j.physbeh.2018.05.030

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 3次元培養骨格筋を活用した収縮筋由来の脳機能関連 マイオカイン分泌研究2021

    • Author(s)
      杉本岳史,中村友浩,横山奨,藤里俊哉,小西聡,橋本健志
    • Organizer
      日本分子生物学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳を鍛える筋収縮!? 骨格筋と脳の機能的連関2021

    • Author(s)
      橋本健志
    • Organizer
      日本体力医学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Lactate, a signaling and functional molecule in muscle and brain2021

    • Author(s)
      Takeshi Hashimoto
    • Organizer
      American College of Sport Medicine
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 運動による認知パフォーマンスの亢進と脳代謝2019

    • Author(s)
      橋本健志
    • Organizer
      第74回日本体力医学会大会.茨城・つくば国際会議場
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 高強度間欠的運動中の音楽傾聴が主観的運動強度と実行機能に及ぼす影響2019

    • Author(s)
      杉本岳史,菅唯志,塚本敏人,伊坂忠夫,橋本健志
    • Organizer
      第74回日本体力医学会大会.茨城・つくば国際会議場
    • Related Report
      2019 Annual Research Report
  • [Presentation] 筋発揮張力維持法を用いた低強度レジスタンス運動が実行機能に及ぼす効果2019

    • Author(s)
      道羅絢斗,菅唯志,杉本岳史,友尾圭吾,塚本敏人,伊坂忠夫,橋本健志
    • Organizer
      第74回日本体力医学会大会.茨城・つくば国際会議場
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高容量低強度レジスタンス運動が実行機能に及ぼす効果2019

    • Author(s)
      友尾圭吾,菅唯志,杉本岳史,田中大智,下寶賢人,道羅絢斗,塚本敏人,橋本健志,伊坂忠夫
    • Organizer
      第74回日本体力医学会大会.茨城・つくば国際会議場
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血流制限下歩行運動における心血管応答および主観的運動強度の増大2019

    • Author(s)
      MOK Kachung,菅唯志,杉本岳史,道羅絢斗,友尾圭吾,橋本健志,伊坂忠夫
    • Organizer
      第74回日本体力医学会大会.茨城・つくば国際会議場
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血流制限下歩行運動が実行機能に及ぼす効果2019

    • Author(s)
      杉本岳史,菅唯志,道羅絢斗,友尾圭吾,塚本敏人,伊坂忠夫,橋本健志
    • Organizer
      第27回日本運動生理学会大会,広島・広島大学
    • Related Report
      2019 Annual Research Report
  • [Presentation] 筋発揮張力維持法を用いた低強度レジスタンス運動は高強度レジスタンス運動と同程度に実行機能を改善する2019

    • Author(s)
      道羅絢斗,菅唯志,杉本岳史,友尾圭吾,塚本敏人,伊坂忠夫,橋本健志
    • Organizer
      第27回日本運動生理学会大会,広島・広島大学
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低強度レジスタンス運動中のセット間短時間休息が実行機能に及ぼす効果2019

    • Author(s)
      友尾圭吾,菅唯志,道羅絢斗,杉本岳史,塚本敏人,橋本健志,伊坂忠夫
    • Organizer
      第27回日本運動生理学会大会,広島・広島大学
    • Related Report
      2019 Annual Research Report
  • [Presentation] Sustainable aerobic exercise mode to improve executive function2019

    • Author(s)
      Sugimoto T, Suga T, Tomoo K, Dora K, Tsukamoto H, Isaka T, Hashimoto T
    • Organizer
      The 1st International Sport Neuroscience Conference 2019, Tsukuba, Ibaraki, Japan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sustainable resistance exercise mode to improve cognitive function2019

    • Author(s)
      Tomoo K, Suga T, Dora K, Sugimoto T, Tsukamoto H, Hashimoto T, Isaka T
    • Organizer
      The 1st International Sport Neuroscience Conference 2019, Tsukuba, Ibaraki, Japan
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The importance of breakfast glycemic control on systemic BDNF and dynamic cerebral autoregulation in men2019

    • Author(s)
      Tsukamoto H, Ishibashi A, Marley CJ, Shinohara Y, Ando S, Bailey DM, Hashimoto T, Ogoh S
    • Organizer
      Physiology 2019, Aberdeen, United Kingdom
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of exercise and brain metabolism on cognitive executive function in human -Lactate as a freind for brain-2019

    • Author(s)
      Hashimoto T
    • Organizer
      24th annual congress of the European College of Sport Science, Prague, Czech Republic
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Catechin-rich green tea intake reduces exercise-induced blood pressure elevation and enhances executive function2019

    • Author(s)
      Tsukamoto H, Hattori T, Hashimoto T
    • Organizer
      24th annual congress of the European College of Sport Science, Prague, Czech Republic
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Self-selected music reduces perceived exertion during high-intensity interval exercise without affecting exercise-induced improvements in inhibitory control2019

    • Author(s)
      Sugimoto T, Suga T, Tsukamoto H, Isaka T, Hashimoto T
    • Organizer
      24th annual congress of the European College of Sport Science, Prague, Czech Republic
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute effect of nutrition intake before or after resistance exercise on muscle breakdown in the morning in healthy young men2019

    • Author(s)
      Kume W, Katayama K, Hashimoto T
    • Organizer
      24th annual congress of the European College of Sport Science, Prague, Czech Republic
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Can repeated bouts of exercise improve equally post-exercise inhibitory control as single bouts of exercise?2019

    • Author(s)
      Sugimoto T, Suga T, Tsukamoto H, Isaka T, Hashimoto T
    • Organizer
      The American College of Sports and Medicine 66th Annual Meeting, Orlando, Florida, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Acute effect of the order of resistance exercise and nutrient intake on muscle breakdown2019

    • Author(s)
      Kume W, Yasuda J, Yoshikawa M, Hashimoto T
    • Organizer
      The American College of Sports and Medicine 66th Annual Meeting, Orlando, Florida, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of low-volume high-intensity interval exercise on post-exercise inhibitory control2019

    • Author(s)
      Sugimoto T, Suga T, Tsukamoto H, Tanaka D, Takenaka S, Shimoho K, Isaka T, Hashimoto T
    • Organizer
      The 9th FAOPS Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of exercise and brain metabolism on cognitive executive function in human2018

    • Author(s)
      Hashimoto T
    • Organizer
      The 30th International Sport Science Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 間欠的運動が運動誘発性の実行機能改善に及ぼす効果2018

    • Author(s)
      杉本岳史, 菅唯志, 塚本敏人, 伊坂忠夫, 橋本健志
    • Organizer
      第31回日本トレーニング科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Plasma oxytocin level is enhanced by acute high-intensity interval exercise in men2018

    • Author(s)
      Tsukamoto H, Olesen ND, Petersen LG, Suga T, Sorensen H, Nielsen HB, Ogoh S, Secher NH, Hashimoto T
    • Organizer
      Europhysiology 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 栄養介入の分子作用機序解明と抗サルコペニアへの応用2018

    • Author(s)
      橋本健志
    • Organizer
      日本スポーツ栄養学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Acute effect of resistance exercise and substancial breakfast on muscle breakdown in healthy young men2018

    • Author(s)
      Kume W, Yoshikawa M, Yasuda J, Hashimoto T
    • Organizer
      European College of Sport Science 23th Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dynamic cerebral autoregulation is not impaired during high-intensity interval exercise2018

    • Author(s)
      Tsukamoto H, Hashimoto T, Olesen ND, Petersen LG, Sorensen H, Nielsen HB, Secher NH, Ogoh S
    • Organizer
      European College of Sport Science 23th Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Book] 「運動と脳機能」 認知症 予防教育.2020

    • Author(s)
      塚本敏人、橋本健志
    • Total Pages
      8
    • Publisher
      日本看護協会出版会
    • ISBN
      9784818022485
    • Related Report
      2019 Annual Research Report
  • [Book] 体育の科学 『トレーニングと認知機能適応』2018

    • Author(s)
      橋本健志、小河繁彦
    • Total Pages
      7
    • Publisher
      杏林書院
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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