Time-series information processing based on complex dynamics in artificial neuronal networks and its computational modelling

• Project/Area Number: 18H03325
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 62010:Life, health and medical informatics-related
• Research Institution: Tohoku University
• Principal Investigator: Yamamoto Hideaki 東北大学, 電気通信研究所, 准教授 (10552036)
• Co-Investigator(Kenkyū-buntansha): 佐藤 茂雄 東北大学, 電気通信研究所, 教授 (10282013)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2018: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
• Keywords: 培養神経回路 / バイオインターフェース / マイクロ加工 / 多細胞システム / 生体情報処理

Outline of Final Research Achievements

We developed a novel perturbation-analysis setup for artificial neuronal networks to constructively investigate the structure-function relationships in neuronal networks, focusing especially on the modular architecture in the nervous system. Using this setup, we unveiled the functional significance of the modular structure through the analysis of their response to asynchronous input and time-series signals.

Academic Significance and Societal Importance of the Research Achievements

深層学習の成功により人工ニューラルネットの研究がにわかに活気を取り戻し，またIoT社会を支える超低消費電力デバイスとして脳型デバイスの開発が加速している．しかし，現行のニューラルネットでは計算過程がブラックボックス化されているため，誤出力が許容されない自動運転などへの実装がはばかられている．また脳型デバイスでも，最先端技術ですら生体脳の効率にはまだ数千倍の隔たりがある．情報化社会が直面しているこれら問題に対して，生物の脳が生体素子に基づいて高次情報処理を実現する作動原理を理解することは新たなブレイクスルーを与える．

Research Products

• [Int'l Joint Research] バルセロナ大学/グラナダ大学(スペイン)
• [Int'l Joint Research] マックス・プランク研究所(ドイツ)
• [Int'l Joint Research] バルセロナ大学/グラナダ大学(スペイン)
• [Int'l Joint Research] マックス・プランク研究所(ドイツ)
• [Int'l Joint Research] ミュンヘン工科大学(ドイツ)
• [Int'l Joint Research] バルセロナ大学(スペイン)
• [Int'l Joint Research] ミネソタ大学(米国)
• [Int'l Joint Research] バルセロナ大学(スペイン)
• [Int'l Joint Research] ミネソタ大学(米国)
• [Int'l Joint Research] ミュンヘン工科大学(ドイツ)
• [Journal Article] An investigation of the relationship between numerical precision and performance of Q-learning for hardware implementation (2022)
  • Author(s): Oguchi Daisuke、Moriya Satoshi、Yamamoto Hideaki、Sato Shigeo
  • Journal Title: Nonlinear Theory and Its Applications, IEICE Volume: 13 Issue: 2 Pages: 427-433
  • DOI: 10.1587/nolta.13.427
  • ISSN: 2185-4106
  • Peer Reviewed / Open Access
• [Journal Article] Selective Stimulation of a Target Neuron in Micropatterned Neuronal Circuits Using a Pair of Needle Electrodes (2021)
  • Author(s): Hattori Kouhei、Kurakake Hekiru、Imai Junko、Hashimoto Takuya、Ishida Mihoko、Sato Koki、Takahashi Honoka、Oguma Soichiro、Yamamoto Hideaki、Hirano-Iwata Ayumi、Tanii Takashi
  • Journal Title: Electrochemistry Volume: 89 Issue: 4 Pages: 348-354
  • DOI: 10.5796/electrochemistry.21-00032
  • NAID: 130008062336
  • ISSN: 1344-3542, 2186-2451
  • Year and Date: 2021-07-05
  • Peer Reviewed / Open Access
• [Journal Article] Analog-circuit implementation of multiplicative spike-timing-dependent plasticity with linear decay (2021)
  • Author(s): Satoshi Moriya; Tatsuki Kato; Daisuke Oguchi; Hideaki Yamamoto; Shigeo Sato; Yasushi Yuminaka; Yoshihiko Horio; Jordi Madrenas
  • Journal Title: Nonlinear Theory and Its Applications, IEICE Volume: 12 Issue: 4 Pages: 685-694
  • DOI: 10.1587/nolta.12.685
  • NAID: 130008098002
  • ISSN: 2185-4106
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A subthreshold spiking neuron circuit based on the Izhikevich model (2021)
  • Author(s): Shigeo Sato; Satoshi Moriya; Yuka Kanke; Hideaki Yamamoto; Yoshihiko Horio; Yasushi Yuminaka; Jordi Madrenas
  • Journal Title: Lecture Notes in Computer Science; Artificial Neural Networks and Machine Learning Volume: 12895 Pages: 177-181
  • DOI: 10.1007/978-3-030-86383-8_14
  • ISBN: 9783030863821, 9783030863838
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Computational Efficiency of a Modular Reservoir Network for Image Recognition (2021)
  • Author(s): Yifan Dai, Hideaki Yamamoto, Masao Sakuraba, and Shigeo Sato
  • Journal Title: Frontiers in Computational Neuroscience Volume: 15 Pages: 594337-594337
  • DOI: 10.3389/fncom.2021.594337
  • Peer Reviewed / Open Access
• [Journal Article] Role of Noise in Spontaneous Activity of Networks of Neurons on Patterned Silicon Emulated by Noise-activated CMOS Neural Nanoelectronic Circuits (2021)
  • Author(s): Hasani Ramin、Ferrari Giorgio、Yamamoto Hideaki、Tanii Takashi、Prati Enrico
  • Journal Title: Nano Express Volume: － Issue: 2 Pages: 100438-100438
  • DOI: 10.1088/2632-959x/abf2ae
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Polydimethylsiloxane microfluidic films for in vitro engineering of small-scale neuronal networks (2020)
  • Author(s): Taiki Takemuro, Hideaki Yamamoto, Shigeo Sato, and Ayumi Hirano-Iwata
  • Journal Title: Japanese Journal of Applied Physics Volume: 59 Issue: 11 Pages: 117001-117001
  • DOI: 10.35848/1347-4065/abc1ac
  • Peer Reviewed / Open Access
• [Journal Article] Modular networks of spiking neurons for applications in time-series information processing (2020)
  • Author(s): Satoshi Moriya, Hideaki Yamamoto, Ayumi Hirano-Iwata, Shigeru Kubota, and Shigeo Sato
  • Journal Title: Nonlinear Theory and Its Applications, IEICE Volume: 11 Issue: 4 Pages: 590-600
  • DOI: 10.1587/nolta.11.590
  • NAID: 130007921436
  • ISSN: 2185-4106
  • Peer Reviewed / Open Access
• [Journal Article] Contribution of AMPA and NMDA receptors in the spontaneous firing patterns of single neurons in autaptic culture (2020)
  • Author(s): Kouhei Hattori, Takeshi Hayakawa, Akira Nakanishi, Mihoko Ishida, Hideaki Yamamoto, Ayumi Hirano-Iwata, Takashi Tanii
  • Journal Title: Biosystems Volume: 198 Pages: 104278-104278
  • DOI: 10.1016/j.biosystems.2020.104278
  • Peer Reviewed / Open Access
• [Journal Article] Printed 3D Electrode Arrays with Micrometer‐Scale Lateral Resolution for Extracellular Recording of Action Potentials (2020)
  • Author(s): Leroy Grob, Hideaki Yamamoto, Sabine Zips, Philipp Rinklin, Ayumi Hirano-Iwata, and Bernhard Wolfrum
  • Journal Title: Advanced Materials Technologies Volume: 5 Issue: 3 Pages: 1900517-1900517
  • DOI: 10.1002/admt.201900517
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suppression of hypersynchronous network activity in cultured cortical neurons using an ultrasoft silicone scaffold (2020)
  • Author(s): Takuma Sumi, Hideaki Yamamoto, and Ayumi Hirano-Iwata
  • Journal Title: Soft Matter Volume: 16 Issue: 13 Pages: 3195-3202
  • DOI: 10.1039/c9sm02432h
  • Peer Reviewed
• [Journal Article] Ultrasoft Silicone Gel as a Biomimetic Passivation Layer in Inkjet-Printed 3D MEA Devices (2019)
  • Author(s): Hideaki Yamamoto, Leroy Grob, Takuma Sumi, Kazuhiro Oiwa, Ayumi Hirano-Iwata, and Bernhard Wolfrum
  • Journal Title: Advanced Biosystems Volume: 3 Issue: 9 Pages: 1900130-1900130
  • DOI: 10.1002/adbi.201900130
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Quantitative Analysis of Dynamical Complexity in Cultured Neuronal Network Models for Reservoir Computing Applications (2019)
  • Author(s): Moriya Satoshi、Yamamoto Hideaki、Hirano-Iwata Ayumi、Kubota Shigeru、Sato Shigeo
  • Journal Title: Proc. 2019 International Joint Conference on Neural Networks (IJCNN) Volume: ー Pages: 1-6
  • DOI: 10.1109/ijcnn.2019.8852207
  • Peer Reviewed
• [Journal Article] 微細加工表面を用いた培養神経回路の構造機能制御―多細胞システムにおける情報処理の理解と応用を目指して― (2019)
  • Author(s): 山本英明、平野愛弓
  • Journal Title: 電子情報通信学会論文誌 C Volume: J102-C Pages: 340-347
  • Open Access
• [Journal Article] Mean-field analysis of directed modular networks (2019)
  • Author(s): S. Moriya, H. Yamamoto, H. Akima, A. Hirano-Iwata, S. Kubota, S. Sato
  • Journal Title: Chaos Volume: 29 Issue: 1 Pages: 013142-013142
  • DOI: 10.1063/1.5044689
  • Peer Reviewed / Open Access
• [Journal Article] Dependence and Homeostasis of Membrane Impedance on Cell Morphology in Cultured Hippocampal Neurons. (2018)
  • Author(s): Matsumura R, Yamamoto H, Hayakawa T, Katsurabayashi S, Niwano M, Hirano-Iwata A.
  • Journal Title: Scientific Reports Volume: 8 (1) Issue: 1 Pages: 9905-9905
  • DOI: 10.1038/s41598-018-28232-0
  • Peer Reviewed / Open Access
• [Journal Article] A single-cell based hybrid neuronal network configured by integration of cell micropatterning and dynamic patch-clamp (2018)
  • Author(s): Yamamoto Hideaki、Hayakawa Takeshi、Netoff Theoden I.、Hirano-Iwata Ayumi
  • Journal Title: Applied Physics Letters Volume: 113 Issue: 13 Pages: 133703-133703
  • DOI: 10.1063/1.5049487
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of modular organization on dynamical richness in cortical networks (2018)
  • Author(s): H. Yamamoto, S. Moriya, K. Ide, T. Hayakawa, H. Akima, S. Sato, S. Kubota, T. Tanii, M. Niwano, S. Teller, J. Soriano, A. Hirano-Iwata
  • Journal Title: Science Advances Volume: 4 Issue: 11
  • DOI: 10.1126/sciadv.aau4914
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 減衰付きSTDP学習則のアナログ回路設計とLSI実装 (2022)
  • Author(s): 守谷 哲, 加藤達暉, 弓仲康史, 山本英明, 佐藤茂雄, 堀尾喜彦
  • Organizer: 電子情報通信学会 ニューロコンピューティング(NC)研究会
• [Presentation] ニューロン回路への応用を目的としたアナログCMOS多数決回路の設計 (2022)
  • Author(s): 小野哲史, 守谷 哲, 菅家由佳, 山本英明, 弓仲康史, 佐藤茂雄
  • Organizer: 電子情報通信学会 ニューロコンピューティング(NC)研究会
• [Presentation] Spiking neuron circuit and efficient CMOS reservoir computing (2022)
  • Author(s): S. Sato, S. Moriya, S. Ono, Y. Kanke, H. Yamamoto, Y. Horio, Y. Yuminaka, J. Madrenas
  • Organizer: The 10th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Dynamical richness defined by modular organization in engineered neuronal networks (2022)
  • Author(s): 山本英明, 平野愛弓, 佐藤茂雄
  • Organizer: 第99回日本生理学会大会
• [Presentation] Artificial reconstitution of neuronal network functions with living cells (2022)
  • Author(s): H. Yamamoto, T. Sumi, T. Takemuro, S. Moriya, S. Sato, A. Hirano-Iwata
  • Organizer: The 3rd International Symposium on Neuromorphic AI Hardware
  • Int'l Joint Research / Invited
• [Presentation] 薄膜型マイクロ流体デバイスを用いた神経細胞モジュール間の結合指向性制御 (2022)
  • Author(s): 門間信明, 山本英明, 竹室汰貴, 守谷 哲, 藤本ありさ, 本田 渉, 平野愛弓, 佐藤茂雄
  • Organizer: 第69回応用物理学会春季学術講演会
• [Presentation] 神経アンサンブルの機能特性のin vitroモデリングに向けた薄膜型マイクロ流体デバイスの作製 (2022)
  • Author(s): 室田白馬, 山本英明, 竹室汰貴, 門間信明, 佐藤茂雄, 平野愛弓
  • Organizer: 第69回応用物理学会春季学術講演会
• [Presentation] 電気刺激による神経細胞回路の自発発火頻度の変調 (2022)
  • Author(s): 岸野颯馬, 鞍掛碧流, 望月直樹, 平野愛弓, 山本英明, 谷井孝至
  • Organizer: 第69回応用物理学会春季学術講演会
• [Presentation] Ultrasoft silicone elastomer as a biomimetic scaffold for neuronal cultures (2021)
  • Author(s): H. Yamamoto, T. Sumi, S. Sato, A. Hirano-Iwata
  • Organizer: European Materials Research Society (E-MRS) 2021 Spring Meeting
  • Int'l Joint Research / Invited
• [Presentation] Ultrasoft polydimethylsiloxane as a biomimetic scaffold for neuronal cultures (2021)
  • Author(s): H. Yamamoto, T. Sumi, S. Sato, A. Hirano-Iwata
  • Organizer: 8th Japan-China Nanomedicine Meeting
  • Int'l Joint Research / Invited
• [Presentation] 神経回路機能のin vitro操作のためのバイオ界面制御技術 (2021)
  • Author(s): 山本英明, 竹室汰貴, 住 拓磨, 佐藤有弥, 守谷 哲, 平野愛弓, 佐藤茂雄, J. Soriano
  • Organizer: 第44回日本神経科学大会
  • Invited
• [Presentation] Tuning synchrony in living neuronal networks through neuroengineering (2021)
  • Author(s): M. Montala-Flaquer, K. Ide, C. Fernandez-Lopez, H. Yamamoto, A. Hirano-Iwata, J. Soriano
  • Organizer: DynamicsDays 2021
  • Int'l Joint Research / Invited
• [Presentation] FORCE法によって訓練された再帰的ニューラルネットワークのグラフ理論的解析 (2021)
  • Author(s): 藤本ありさ, 山本英明, 守谷 哲, 佐藤茂雄
  • Organizer: 非線形ワークショップ2021夏合宿
• [Presentation] マイクロパターン培養神経回路に対する光摂動系の構築 (2021)
  • Author(s): 竹室汰貴, 山本英明, 脇村 桂, 住 拓磨, 金野智浩, 佐藤茂雄, Jordi Soriano, 平野愛弓
  • Organizer: 第82回応用物理学会秋季学術講演会
• [Presentation] 多点電極アレイ上でのモジュール構造型培養神経回路のパターニング (2021)
  • Author(s): 佐藤有弥, 山本英明, 竹室汰貴, 住 拓磨, 酒井原一守, 谷井孝至, 佐藤茂雄, 平野愛弓
  • Organizer: 第82回応用物理学会秋季学術講演会
• [Presentation] 帰還接続における伝搬遅延によるSTDPシナプスの選別 (2021)
  • Author(s): 望月直樹, 石田実穂子, 鞍掛碧流, 池田 翔, 山本英明, 平野愛弓, 谷井孝至
  • Organizer: 第31回日本神経回路学会全国大会
• [Presentation] リカレントニューラルネットワークの固有値分布における対称性解析 (2021)
  • Author(s): 藤本ありさ, 山本英明, 守谷 哲, 佐藤茂雄
  • Organizer: 第31回日本神経回路学会全国大会
• [Presentation] 人工神経回路への 2 針電極による刺激と応答計測 (2021)
  • Author(s): 鞍掛碧流, 望月直樹, 池田 翔, 岸野颯馬, 小熊奏一郎, 藤原 彩, 山本英明, 平野愛弓, 谷井孝至
  • Organizer: 第31回日本神経回路学会全国大会
• [Presentation] リザバー計算に基づく人工神経細胞回路のパターン分類特性の評価 (2021)
  • Author(s): 住 拓磨, 山本英明, 守谷 哲, 竹室汰貴, 金野智浩, 佐藤茂雄, 平野愛弓
  • Organizer: 第31回日本神経回路学会全国大会
• [Presentation] マイクロパターン培養神経回路のリザバー計算特性の解析 (2021)
  • Author(s): 住 拓磨, 山本英明, 守谷 哲, 竹室汰貴, 金野智浩, 佐藤茂雄, 平野愛弓
  • Organizer: 電子情報通信学会 ニューロコンピューティング(NC)研究会
• [Presentation] FPGA実装に向けた強化学習モデルの丸め誤差と学習性能に関する考察 (2021)
  • Author(s): 小口大輔, 守谷 哲, 山本英明, 佐藤茂雄
  • Organizer: 電子情報通信学会 ニューロコンピューティング(NC)研究会
• [Presentation] バイオ界面制御による神経回路機能の人工再構成 (2021)
  • Author(s): 山本英明, 平野愛弓, 佐藤茂雄
  • Organizer: 薄膜材料デバイス研究会第18回研究集会
  • Invited
• [Presentation] Polydimethylsiloxane microfluidic films for in vitro engineering of mesoscale neuronal networks (2021)
  • Author(s): H. Yamamoto, T. Takemuro, N. Monma, S. Sato, A. Hirano-Iwata
  • Organizer: 14th International Symposium on Nanomedicine (ISNM2021)
  • Int'l Joint Research / Invited
• [Presentation] An investigation of the Relationship between numerical precision and performance of Q-learning for hardware implementation (2021)
  • Author(s): D. Oguchi, S. Moriya, H. Yamamoto, S. Sato
  • Organizer: The 2021 Nonlinear Science Workshop (NLSW2021)
  • Int'l Joint Research
• [Presentation] Designing functional neuronal networks with living cells (2021)
  • Author(s): H. Yamamoto, A. Hirano-Iwata, S. Sato
  • Organizer: Asia South Pacific Design Automation Conference (ASP-DAC 2021)
  • Int'l Joint Research / Invited
• [Presentation] FPGA上で動作する強化学習モデルの計算性能評価 (2021)
  • Author(s): 小口大輔，守谷 哲，熊谷 俊，山本英明，佐藤茂雄
  • Organizer: 2021年電子情報通信学会総合大会
• [Presentation] FORCE学習法によって訓練されたリカレントニューラルネットワークのグラフ理論的解析 (2021)
  • Author(s): 藤本ありさ，山本英明，守谷 哲，佐藤茂雄
  • Organizer: 2021年電子情報通信学会総合大会
• [Presentation] Modeling of cultured neuronal networks for analog hardware implementation (2021)
  • Author(s): S. Moriya, H. Yamamoto, S. Sato
  • Organizer: The 4th Tohoku-NTU Symposium on Interdisciplinary AI and Human Studies
  • Int'l Joint Research
• [Presentation] In silico/in vitro神経回路におけるリザーバ計算特性のモジュール構造依存性 (2021)
  • Author(s): 住 拓磨，山本英明，竹室汰貴，守谷 哲，佐藤茂雄，平野愛弓
  • Organizer: 第68回応用物理学会春季学術講演会
• [Presentation] マイクロパターン上の神経回路における標的ニューロンへの二本針電極を用いた選択的刺激 (2021)
  • Author(s): 小熊奏一郎，服部晃平，鞍掛碧流，今井絢子，石田実穂子，髙橋穂乃歌，山本英明，平野愛弓，谷井孝至
  • Organizer: 第68回応用物理学会春季学術講演会
• [Presentation] Analog CMOS Neural Network for Edge Computing (2021)
  • Author(s): S. Sato, S. Moriya, Y. Tamura, T. Kato, Y. Kanke, H. Yamamoto, M. Sakuraba, Y. Horio, Y. Yuminaka, J. Madrenas
  • Organizer: The 7th International Symposium on Brainware LSI
  • Int'l Joint Research
• [Presentation] 脳組織に近い弾性率を有するシリコーン樹脂の生体界面材料応用 (2020)
  • Author(s): 山本英明、住拓磨、佐藤茂雄、平野愛弓
  • Organizer: 応用物理学会有機分子・バイオエレクトロニクス分科会研究会
• [Presentation] 薄膜型マイクロ流路を用いた微小神経細胞回路のパターン培養 (2020)
  • Author(s): 竹室 汰貴、山本 英明、佐藤 茂雄、平野 愛弓
  • Organizer: 第81回応用物理学会秋季学術講演会
• [Presentation] 伝搬遅延を組み入れたリザーバ／出力層の教師なしSTDP学習の検討 (2020)
  • Author(s): 加藤達暉, 守谷 哲, 山本英明, 櫻庭政夫, 佐藤茂雄
  • Organizer: 2020年電子情報通信学会ソサイエティ大会
• [Presentation] スパイキングニューロン間の局所相互作用に基づくリザーバ／出力層の教師なし学習の検討 (2020)
  • Author(s): 加藤達暉, 守谷 哲, 山本英明, 櫻庭政夫, 佐藤茂雄
  • Organizer: 電子情報通信学会 ニューロコンピューティング(NC)研究会
• [Presentation] Analog CMOS Implementation of a Spiking Neuron Circuit for Edge Computing (2020)
  • Author(s): S. Sato, Y. Tamura, S. Moriya, H. Yamamoto, M. Sakuraba, Y. Horio, J. Madrenas
  • Organizer: 2020 International Symposium on Nonliner Theory and Its Applications (NOLTA 2020)
  • Int'l Joint Research
• [Presentation] マイクロコンタクトプリンティング法による培養神経回路のパターニング (2020)
  • Author(s): 佐藤有弥, 山本英明, 竹室汰貴, 住 拓磨, 谷井孝至, 平野愛弓
  • Organizer: 6大学連携プロジェクト第5回公開討論会
• [Presentation] エッジコンピューティング向けスパイキングニューラルネットワークのCMOS回路による構成 (2020)
  • Author(s): 佐藤茂雄, 守谷 哲, 加藤達暉, 山本英明, 堀尾喜彦, J. Madrenas
  • Organizer: 第30回日本神経回路学会全国大会
  • Invited
• [Presentation] モジュール構造型神経ネットワークにおける時空間ダイナミクスの時系列情報処理応用 (2020)
  • Author(s): 守谷 哲, 山本英明, 平野愛弓, 久保田 繁, 佐藤茂雄
  • Organizer: 第30回日本神経回路学会全国大会
• [Presentation] オータプス伝搬遅延によるSTDPシナプスの淘汰: 孤立した単一神経細胞に関する数理モデル化 (2020)
  • Author(s): 石田実穂子, 中西 彬, 服部晃平, 山本英明, 平野愛弓, 谷井孝至
  • Organizer: 第30回日本神経回路学会全国大会
• [Presentation] 初代神経細胞パターニングのための薄膜型マイクロ流路の開発 (2020)
  • Author(s): 竹室汰貴, 山本英明, 佐藤茂雄, 平野愛弓
  • Organizer: 第30回日本神経回路学会全国大会
• [Presentation] ニューロン間の局所的相互作用に基づくリザーバ計算用教師なし学習モデルの提案 (2020)
  • Author(s): 加藤達暉, 守谷 哲, 山本英明, 櫻庭政夫, 佐藤茂雄
  • Organizer: 第30回日本神経回路学会全国大会
• [Presentation] 強化学習のエッジ処理を可能とするスケーラブルな専用ハードウェアの実装 (2020)
  • Author(s): 小口大輔, 守谷 哲, 山本英明, 佐藤茂雄
  • Organizer: 第30回日本神経回路学会全国大会
• [Presentation] Ultrasoft silicone gel as a biomimetic scaffold for culturing neuronal networks in vitro (2020)
  • Author(s): H. Yamamoto, T. Sumi, A. Hirano-Iwata, S. Sato
  • Organizer: 9th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] CMOS analog neural circuit for edge computing (2020)
  • Author(s): S. Sato, Y. Tamura, S. Moriya, H. Yamamoto, M. Sakuraba, Y. Horio, J. Madrenas
  • Organizer: 9th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Microcontact printing of extracellular matrix proteins for neuronal patterning on high-density multielectrode arrays (2020)
  • Author(s): S. Sato, Y. Tamura, S. Moriya, H. Yamamoto, M. Sakuraba, Y. Horio, J. Madrenas
  • Organizer: 9th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Reservoir computing properties in spiking neural network models with modular topology (2020)
  • Author(s): T. Sumi, H. Yamamoto, S. Moriya, T. Takemuro, S. Sato, A. Hirano-Iwata
  • Organizer: 9th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Extracellular stimulation of a target neuron in a micropatterned neuronal circuit using a pair of needle electrodes (2020)
  • Author(s): K. Hattori, M. Ishida, H. Takahashi, S. Oguma, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 9th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] 実細胞を用いた神経回路機能の人工再構成 (2020)
  • Author(s): 山本英明
  • Organizer: 国際ナノテクノロジー総合展・技術会議（Nanotech 2020）
  • Invited
• [Presentation] Analog neuron circuit for edge computing (2020)
  • Author(s): S. Sato, Y. Tamura, S. Moriya, T. Kato, H. Yamamoto, M. Sakuraba, Y. Horio, J. Madrenas
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] An experimental study on the spontaneous firing of single isolated neurons in autaptic culture using micropatterned substrates (2020)
  • Author(s): K. Hattori, K. Sato, H. Takahashi, T. Hayakawa, S. Oguma, M. Ishida, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Stimulation of micropatterned neurons with a pair of needle electrodes and the activity measurement (2020)
  • Author(s): J. Imai, K. Hattori, H. Kurakake, T. Hashimoto, K. Sato, H. Takahashi, S. Oguma, M. Ishida, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Controlling synchronized bursting activity of micropatterned cortical cultures by electrical field noise (2020)
  • Author(s): K. Wakimura, H. Yamamoto, K. Ide, A. Hirano-Iwata
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Soft scaffolds suppress hypersynchronous network activity in cultured cortical neurons (2020)
  • Author(s): T. Sumi, H. Yamamoto, A. Hirano-Iwata
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Patterning neuronal networks in modular structure using thin PDMS microfluidics films (2020)
  • Author(s): T. Takemuro, H. Yamamoto, K. Wakimura, S. Sato, A. Hirano-Iwata
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Computational modeling of cultured neuronal networks and its reservoir computing applications (2020)
  • Author(s): S. Moriya, H. Yamamoto, Z. Chen, K. Wakimura, A. Hirano-Iwata, S. Kubota, S. Sato
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] LSI implementation and its evaluation of an Izhikevich neuron model (2020)
  • Author(s): Y. Tamura, S. Moriya, T. Kato, H. Yamamoto, M. Sakuraba, S. Sato, Y. Horio, J. Madrenas
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Biointerface engineering technologies for manipulating neuronal network functions in culture (2020)
  • Author(s): H. Yamamoto, K. Wakimura, Z. Chen, T. Sumi, T. Takemuro, A. Hirano-Iwata, S. Sato
  • Organizer: 8th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] マイクロ加工培養神経回路の外部ノイズ刺激応答の解析 (2020)
  • Author(s): 住 拓磨，山本 英明，脇村 桂，佐藤 茂雄，平野 愛弓
  • Organizer: 第67回応用物理学会春季学術講演会
• [Presentation] 神経細胞パターニングのための薄膜型PDMSマイクロ流路の開発 (2020)
  • Author(s): 竹室 汰貴，山本英明，脇村 桂，佐藤茂雄，平野愛弓
  • Organizer: 第67回応用物理学会春季学術講演会
• [Presentation] 2針電極を用いた神経細胞刺激の応答計測とその理論解析 (2020)
  • Author(s): 服部晃平，鞍掛碧流，今井絢子，橋本拓弥，石田実穂子，佐藤晃揮，髙橋穂乃歌，小熊奏一郎，山本英明，平野愛弓，谷井孝至
  • Organizer: 第67回応用物理学会春季学術講演会
• [Presentation] マイクロパターン上の神経細胞への2針電極による刺激とその応答計測 (2020)
  • Author(s): 鞍掛碧流，服部晃平，今井絢子，橋本拓弥，佐藤晃揮，髙橋穂乃歌，小熊奏一郎，石田実穂子，山本英明，平野愛弓，谷井孝至
  • Organizer: 第67回応用物理学会春季学術講演会
• [Presentation] 神経回路における構造機能相関のin vitroモデリング (2020)
  • Author(s): 山本英明，平野愛弓
  • Organizer: 第97回日本生理学会大会
  • Invited
• [Presentation] Engineering the structure and function of neuronal networks in vitro (2019)
  • Author(s): H. Yamamoto, A. Hirano-Iwata
  • Organizer: 7th China-Japan Symposium on Nanomedicine
  • Int'l Joint Research / Invited
• [Presentation] Acute and transient responses of cultured cortical networks to electric-field noise (2019)
  • Author(s): K. Wakimura, H. Yamamoto, K. Ide, A. Hirano-Iwata
  • Organizer: 10th International Conference on Molecular Electronics & BioElectronics (M&BE10)
  • Int'l Joint Research
• [Presentation] 電気的外部ノイズ下における培養神経回路の活動パターン (2019)
  • Author(s): 脇村 桂，山本英明，井手克哉，平野愛弓
  • Organizer: 第42回日本神経科学大会
• [Presentation] Engineering network synchrony in cultured cortical neurons using microfabricated scaffolds (2019)
  • Author(s): Hideaki Yamamoto
  • Organizer: Synchronization phenomena on complex networks, from math to experiments --Special workshop for AIMR Advanced Target Projects--
  • Int'l Joint Research
• [Presentation] Functional Connectivity in Engineered Neuronal Cultures: Challenges and Opportunities (2019)
  • Author(s): M. Montala, E. Estevez-Priego, A. A. Ludl, H. Yamamoto, J. Soriano
  • Organizer: LANET (Latin American Conference on Complex Networks)-2019
  • Int'l Joint Research
• [Presentation] Synaptic plasticity in an isolated single autaptic neuron on a micropattern. (2019)
  • Author(s): A. Nakanishi, K. Hattori, T. Hayakawa, M. Ishida, H. Kurakake, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 第29回日本神経回路学会全国大会
• [Presentation] 平行板電極を用いた外部ノイズ印可による培養神経回路の同期バースト変調効果の解析 (2019)
  • Author(s): 脇村 桂，山本英明，井手克哉，平野愛弓
  • Organizer: 第80回応用物理学会秋季学術講演会
• [Presentation] 高次元リザーバの実細胞再構成に向けた培養神経回路の伝搬指向性制御 (2019)
  • Author(s): 袁 之雄，山本英明，守谷 哲，井手克哉，脇村 桂，竹室汰貴，久保田 繁，佐藤茂雄，平野愛弓
  • Organizer: 第80回応用物理学会秋季学術講演会
• [Presentation] 生体脳組織の弾性率を模倣した超軟シリコーン樹脂上での神経細胞培養 (2019)
  • Author(s): 住 拓磨，山本英明，平野愛弓
  • Organizer: 第80回応用物理学会秋季学術講演会
• [Presentation] 2本針型刺激電極の試作とマイクロパターン上神経細胞回路への刺激導入に関する実行可能性評価 (2019)
  • Author(s): 服部晃平，鞍掛碧流，今井絢子，橋本拓弥，佐藤晃揮，髙橋穂乃歌，早川岳志，山本英明，平野愛弓，谷井孝至
  • Organizer: 第80回応用物理学会秋季学術講演会
• [Presentation] A computational study on the spontaneous firing pattern of single autaptic neurons -The contribution of AMPA and NMDA current- (2019)
  • Author(s): M. Ishida, K. Hattori, A. Nakanishi, T. Hayakawa, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 4th International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-4)
  • Int'l Joint Research
• [Presentation] Microcontact printing of scaffold proteins for engineering neuronal network functions (2019)
  • Author(s): H. Yamamoto, S. Moriya, K. Ide, T. Hayakawa, H. Akima, S. Sato, S. Kubota, M. Niwano, S. Teller, J. Soriano, T. Tanii, A. Hirano-Iwata
  • Organizer: 4th International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-4)
  • Int'l Joint Research
• [Presentation] An experimental study on the spontaneous firing of single isolated autaptic neurons using micropatterned substrates (2019)
  • Author(s): H. Takahashi, K. Sato, S. Oguma, T. Hayakawa, K. Hattori, H. Yamamoto, A Hirano-Iwata, T. Tanii
  • Organizer: 4th International Symposium on Creation of Life Innovation Materials for Interdisciplinary and International Researcher Development (iLIM-4)
  • Int'l Joint Research
• [Presentation] 微細加工基板を用いた神経回路ダイナミクスの in vitro 制御 (2019)
  • Author(s): 山本英明，守谷 哲，井手克哉，早川岳志，秋間学尚，佐藤茂雄，久保田 繁，谷井孝至，Sara Teller，Jordi Soriano，平野愛弓
  • Organizer: 2019年日本表面真空学会学術講演会
• [Presentation] Controlling structure and function of neuronal networks in 2D using microcontact-printed protein scaffolds (2019)
  • Author(s): H. Yamamoto, K. Wakimura, Z. Chen, T. Sumi, T. Takemuro, T. Tanii, A. Hirano-Iwata
  • Organizer: Okinawa Colloids 2019
  • Int'l Joint Research
• [Presentation] Ultrasoft silicone gel as a biomimetic culture scaffold for cortical neurons (2019)
  • Author(s): H. Yamamoto, T. Sumi, L. Grob, B. Wolfrum, A. Hirano-Iwata
  • Organizer: 13th International Symposium on Nanomedicine (ISNM2019)
  • Int'l Joint Research / Invited
• [Presentation] Impact of spontaneous activation of stretch-activated channels on the generation and size of neuronal network activity (2019)
  • Author(s): T. Sumi, H. Yamamoto, A. Hirano-Iwata
  • Organizer: 13th International Symposium on Nanomedicine (ISNM2019)
  • Int'l Joint Research
• [Presentation] Time-series information processing in cultured neuronal network models (2019)
  • Author(s): S. Moriya, H. Yamamoto, Z. Chen, K. Wakimura, A. Hirano-Iwata, S. Kubota, S. Sato
  • Organizer: The 2019 International Symposium on Nonlinear Theory and its Applications (NOLTA2019)
  • Int'l Joint Research
• [Presentation] Microfabrication technologies for engineering the structure and function of biological neuronal networks (2019)
  • Author(s): H. Yamamoto
  • Organizer: International Workshop of Emerging Technologies for Brainware LSI and its Applications
  • Int'l Joint Research
• [Presentation] Dynamical richness in modular cortical networks emerges as trade-off between functional integrability and spatial segregation (2019)
  • Author(s): H. Yamamoto, S. Moriya, K. Ide, T. Hayakawa, H. Akima, S. Sato, S. Kubota, T. Tanii, M. Niwano, S. Teller, J. Soriano, A. Hirano-Iwata
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Analysis of dynamical complexity in modular neuronal network models (2019)
  • Author(s): S. Moriya, H. Yamamoto, A. Hirano-Iwata, S. Kubota, S. Sato
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Functional complexity in neuronal network models with hierarchically modular organization (2019)
  • Author(s): Z. Chen, H. Yamamoto, S. Moriya, K. Ide, S. Kubota, S. Sato, A. Hirano-Iwata
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Structure-dependence of stimulus responses in micropatterned neuronal networks (2019)
  • Author(s): T. Hayakawa, H. Yamamoto, K. Ide, A. Hirano-Iwata
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] High-speed imaging of spontaneous activity in micropatterned cortical cultures: Impact of modular organization (2019)
  • Author(s): K. Wakimura, H. Yamamoto, K. Ide, A. Hirano-Iwata
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Functional characterization of cultured neuronal netoworks on ultrasoft gels (2019)
  • Author(s): T. Sumi, H. Yamamoto, A. Hirano-Iwata
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Computational modeling of spontaneous firing patterns generated by single autaptic neurons (2019)
  • Author(s): K. Hattori, T. Hayakawa, A. Nakanishi, M. Ishida, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] An experimental study on spontaneous firing of a single neuron on micropatterned substrates (2019)
  • Author(s): K. Sato, T. Nakane, H. Takahashi, K. Hattori, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Surface modification with visible-light-responsive TiO2 thin film (2019)
  • Author(s): A. Kurotobi, S. Kono, T. Ichikawa, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 7th RIEC International Symposium on Brain Functions and Brain Computer
  • Int'l Joint Research
• [Presentation] Engineering neuronal network functions in culture using microfabricated surfaces (2019)
  • Author(s): H. Yamamoto
  • Organizer: KTH Royal Insitute of Technology-CST Seminar
  • Int'l Joint Research / Invited
• [Presentation] マイクロパターン培養細胞を用いた神経回路応答の構成論的解析 (2019)
  • Author(s): 早川岳志, 山本英明, 平野愛弓
  • Organizer: 第66回応用物理学会春季学術講演会
• [Presentation] Dependence of membrane impedance on cell morphology in cultured hippocampal neurons (2018)
  • Author(s): H. Yamamoto, R. Matsumura, T. Hayakawa, S. Katsurabayashi, M. Niwano, A. Hirano-Iwata
  • Organizer: 11th FENS Forum of Neuroscience
  • Int'l Joint Research
• [Presentation] Spontaneous activity patterns in micropatterned cortical cultures: Influence of modular organization (2018)
  • Author(s): K. Wakimura, H. Yamamoto, K. Ide, S. Moriya, S. Sato, J. Soriano-Fradera, A. Hirano-Iwata
  • Organizer: 11th FENS Forum of Neuroscience
  • Int'l Joint Research
• [Presentation] Modular and global synchronization in modular neuronal network models (2018)
  • Author(s): S. Moriya, H. Yamamoto, K. Ide, H. Akima, J. Soriano-Fradera, A. Hirano-Iwata, S. Kubota, S. Sato
  • Organizer: 11th FENS Forum of Neuroscience
  • Int'l Joint Research
• [Presentation] Bottom-up engineering of neuronal network function using microfabricated surfaces (2018)
  • Author(s): H. Yamamoto, K. Ide, K. Wakimura, A. Hirano-Iwata
  • Organizer: European Materials Research Society (E-MRS) 2018 Fall Meeting
  • Int'l Joint Research / Invited
• [Presentation] 階層的モジュール構造を有する培養神経回路のin vitro再構成 (2018)
  • Author(s): 井手克哉, 山本英明, 脇村 桂, 守谷 哲, 袁 之雄, 久保田 繁, 佐藤茂雄, 平野愛弓
  • Organizer: 第79回応用物理学会秋季学術講演会
• [Presentation] 階層的モジュール構造を有する神経回路網モデルにおける活動パターンの機能的複雑性 (2018)
  • Author(s): 袁 之雄, 山本英明, 守谷 哲, 井手克哉, 久保田 繁, 佐藤茂雄, 平野愛弓
  • Organizer: 電子情報通信学会 ニューロコンピューティング(NC)研究会
• [Presentation] モジュール構造型神経回路モデルにおける興奮性－抑制性均衡とネットワークダイナミクス (2018)
  • Author(s): 守谷 哲, 山本英明, 袁 之雄, 井手克哉, 脇村 桂, 平野愛弓, 久保田 繁, 佐藤茂雄
  • Organizer: 電子情報通信学会 ニューロコンピューティング(NC)研究会
• [Presentation] Computational modelling of spontaneous firing patterns generated by single autaptic neurons (2018)
  • Author(s): K. Hattori, T. Hayakawa, A. Nakanishi, M. Ishida, H. Yamamoto, A. Hirano-Iwata, T. Tanii
  • Organizer: 第28回日本神経回路学会全国大会
• [Presentation] 超軟ゲル材料表面を用いた神経細胞の生体模倣培養技術の開発 (2018)
  • Author(s): 住 拓磨, 山本英明, 早川岳志, 井手克哉, 木野久志, 田中 徹, 平野愛弓
  • Organizer: 2018年日本表面真空学会学術講演会
• [Presentation] Surface micropatterning techniques for reconstituting functional neuronal networks in culture (2018)
  • Author(s): H. Yamamoto, A. Hirano-Iwata
  • Organizer: Pacific Rim Symposium on Surfaces, Coatings & Interfaces (PacSurf 2018)
  • Int'l Joint Research / Invited
• [Book] 百科繚覧 VOL.2 (2020)
  • Author(s): 東北大学学際科学フロンティア研究所「百科繚覧」編集委員会
  • Total Pages: 160
  • Publisher: 東北大学出版会
  • ISBN: 9784861633294
• [Remarks] 東北大学 平野研究室
  • URL: http://www.riec.tohoku.ac.jp/~hir-lab/
• [Remarks] 微細なハンコで神経回路網を操作 -シャーレ内での脳機能モデリングに向けて道筋-
  • URL: http://www.tohoku.ac.jp/japanese/2018/11/press-20181115-stamp.html
• [Remarks] 神経科学: シャーレの中の神経回路網
  • URL: https://www.wpi-aimr.tohoku.ac.jp/jp/aimresearch/highlight/2019/20190225_001120.html