| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
The study has conducted the association study (eQTL analysis) to about 300 Japanese pregnant women between more than ten millions variants from whole genome sequencing and RNA sequencing at three points (two data points in pregnancy and one point in postpartum). The gene-variants relationship was categorized into seven patterns (detected the common relationship in three points and specific in pregnancy or postpartum). Based on this result, the study also constructed an eQTL database of Japanese pregnant women. The database is especially useful for both for domestic and global researchers to understand the mechanisms from pregnancy to postpartum periods.
Parts of the gene-variants relationship in this database matched to the relationship in the diseases associated SNP catalog database, GWASCatalog. The result naturally suggests that the reported disease might also affect the Japanese women via these gene-variant cascades. Thus, the database can be used also for general periods.
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