| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
Most of the protein hetero oligomers are the transient complexes and regulate physiological activities. Because protein structural change associates with its function, the study of the structural change is important to elucidate the molecular mechanism of protein function. In this study, we extracted the most plausible physiological structures of oligomers from the PDB. We compared structures of the identical hetero-dimers, analysed structural changes systematically and classified them using the protein families as the unit of statistics. To this purpose, we utilized two original applications. SCPS detected the binding mode of hetero-dimers and Motion Tree identified and illustrated structural changes. We found that the interface motions are rarer in the hetero-dimers than the homo-dimers.
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