Engineering synthetic cell-cell signaling that transmit dynamic information
| Project/Area Number |
18H03332
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 62010:Life, health and medical informatics-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Keywords | 合成生物学 / 人工遺伝子回路 / 光遺伝学 / 細胞間コミュニケーション / Notchシグナル / 分節時計 |
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| Outline of Final Research Achievements |
We thought to build novel cell-cell signaling pathway that can transmit dynamic information in mammalian cells. We modified ligands and receptors of the synNotch signaling pathway, and found that the engineered pathway can transmit oscillatory information in sender cells to receiver cells.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究によって、効率的な動的情報伝達を可能とする人工リガンド・人工受容体の選別プラットフォームが実現した。この技術の更なる進展によって、哺乳動物細胞の多細胞動態を人工遺伝子回路を使って制御・再構築することが可能になり、再生医療に資する人工多細胞組織の作製などの応用に繋がることが期待される。
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Report
(4 results)
Research Products
(5 results)
