| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Outline of Final Research Achievements |
In this study, we conducted a risk assessment of fluorene-9-bisphenol (BHPF), a bisphenol A alternative for which no prior risk assessment has been performed. We evaluated BHPF toxicity using a guideline-based toxicity test and investigated its endocrine-disrupting effects in detail using estrogen-responsive reporter mice that we established. As a result, we identified the no-observed-adverse-effect level (NOAEL) of BHPF and determined a dose range within which it can be safely used. Additionally, although BHPF was detected in human blood at low levels, its presence suggests that humans are exposed to a certain amount of BHPF.
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