Transfer of mercury and other trace elements between dam and fetus, and search of related gene expression in the small Indian mongoose.
| Project/Area Number |
18H03386
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 63040:Environmental impact assessment-related
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| Research Institution | National Institute for Minamata Disease (2020-2022)
Tottori University (2018-2019) |
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Principal Investigator |
Horai Sawako 国立水俣病総合研究センター, その他部局等, 室長 (60512689)
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| Co-Investigator(Kenkyū-buntansha) |
国末 達也 愛媛大学, 沿岸環境科学研究センター, 教授 (90380287)
杉山 晶彦 岡山理科大学, 獣医学部, 教授 (00432609)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 水銀高蓄積種 / 微量元素 / 水銀 / セレン / ヒ素 / 母子間移行 / フイリマングース / 環境モニタリング / マングース / 毒性影響 |
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| Outline of Final Research Achievements |
The Small Indian mongoose is listed as one of the world's 100 worst alien species, and in the areas where it is introduced, it is subject to extermination in order to prevent destruction of the native ecosystem. The purpose of which was to elucidate the characteristics of dam-to-fetus transfer due to exposure to trace elements in the natural environment.
As a result of analyzing 29 pairs of dams with high mercury levels and their fetuses, a strong positive correlation was observed between the concentration of organic mercury in maternal whole blood and fetal blood, as in humans.Mongoose fetuses were suggested to transfer less mercury from their mothers than humans. From the analysis, it was inferred that the mineralization of organic mercury and the arsenic concentration in the fetal liver were involved as factors for low mercury transfer to fetus brain.
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| Academic Significance and Societal Importance of the Research Achievements |
フイリマングースはヒトと同様に、飼育管理された動物ではない。自然環境下で化学物質の複合曝露を受け、系統や週令も不明である。今回、母親の微量元素の曝露レベルの違いによる胎仔の体内応答の一端を明らかにすることができた。本研究結果をもとに、ハイリスクアニマルの特定や、微量元素の胎仔体内レベルの推定に貢献できると期待する。
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Report
(5 results)
Research Products
(7 results)
