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Transfer of mercury and other trace elements between dam and fetus, and search of related gene expression in the small Indian mongoose.

Research Project

Project/Area Number 18H03386
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 63040:Environmental impact assessment-related
Research InstitutionNational Institute for Minamata Disease (2020-2022)
Tottori University (2018-2019)

Principal Investigator

Horai Sawako  国立水俣病総合研究センター, その他部局等, 室長 (60512689)

Co-Investigator(Kenkyū-buntansha) 国末 達也  愛媛大学, 沿岸環境科学研究センター, 教授 (90380287)
杉山 晶彦  岡山理科大学, 獣医学部, 教授 (00432609)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords水銀高蓄積種 / 微量元素 / 水銀 / セレン / ヒ素 / 母子間移行 / フイリマングース / 環境モニタリング / マングース / 毒性影響
Outline of Final Research Achievements

The Small Indian mongoose is listed as one of the world's 100 worst alien species, and in the areas where it is introduced, it is subject to extermination in order to prevent destruction of the native ecosystem. The purpose of which was to elucidate the characteristics of dam-to-fetus transfer due to exposure to trace elements in the natural environment.
As a result of analyzing 29 pairs of dams with high mercury levels and their fetuses, a strong positive correlation was observed between the concentration of organic mercury in maternal whole blood and fetal blood, as in humans.Mongoose fetuses were suggested to transfer less mercury from their mothers than humans. From the analysis, it was inferred that the mineralization of organic mercury and the arsenic concentration in the fetal liver were involved as factors for low mercury transfer to fetus brain.

Academic Significance and Societal Importance of the Research Achievements

フイリマングースはヒトと同様に、飼育管理された動物ではない。自然環境下で化学物質の複合曝露を受け、系統や週令も不明である。今回、母親の微量元素の曝露レベルの違いによる胎仔の体内応答の一端を明らかにすることができた。本研究結果をもとに、ハイリスクアニマルの特定や、微量元素の胎仔体内レベルの推定に貢献できると期待する。

Report

(5 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (7 results)

All 2023 Other

All Int'l Joint Research (6 results) Presentation (1 results)

  • [Int'l Joint Research] USDA(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Ross Univeristy(セントクリストファー・ネービス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Mauritius Wildlife Foundation(モーリシャス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] モントリオール大学(カナダ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 農務省/パデュー大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] セントキッツ島/ロス大学(その他の国・地域)

    • Related Report
      2019 Annual Research Report
  • [Presentation] 水銀高蓄積野生動物種における水銀およびその他微量元素の母子間移行‐フイリマングースを例に‐2023

    • Author(s)
      寳來佐和子
    • Organizer
      第2回環境化学物質3学会合同大会
    • Related Report
      2021 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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