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Development of analytical method of nitrogen stable isotope ratio of water-soluble pesticides

Research Project

Project/Area Number 18H03393
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 64010:Environmental load and risk assessment-related
Research InstitutionAkita Prefectural University

Principal Investigator

Kawashima Hiroto  秋田県立大学, システム科学技術学部, 准教授 (60381331)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2018: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords安定同位体 / 環境鑑識 / 食品分析 / 農薬分析 / 危機管理 / 鑑識学 / 輸入食品 / 残留農薬 / 環境分析 / 安定同位体比 / 異同識別 / 窒素安定同位体比
Outline of Final Research Achievements

Liquid chromatography/isotope ratio mass spectrometry (LC/IRMS) has been used to authenticate and trace products such as honey, wine, and lemon juice, and compounds such as caffeine and pesticides. However, LC/IRMS has several disadvantages, including the high cost of the CO2 membrane and blocking by solidified sodium persulfate. Here, I conducted as follows 3 points. Firstly, I developed a two-dimensional LC/IRMS and measured organic acids in honey. Secondly, I measured ethanol, sugars, and organic acids in sake. Thirdly, I established an analytical method for pesticides using LC/IRMS and attempted nitrogen stable isotope ratio analysis.

Academic Significance and Societal Importance of the Research Achievements

本研究では,既存のLC/IRMSに二次元LCを追加し,今まで測定できなかった成分中の安定同位体比分析が可能になった。さらに,固相抽出法を使い,夾雑成分の除去を行い,ターゲットとする成分中の安定同位体比分析を行った。また,日本酒のアルコール類,糖類,有機酸類の安定同位体比を分析することで,普通酒,醸造酒の区分や酒造りの区分を行うことが可能になった。これらは,学術的にも大きな進展になると共に,日本酒の偽装を防止予防も可能になるなど社会的意義も大きいと思われる。

Report

(4 results)
  • 2021 Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (26 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 4 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Remarks (3 results)

  • [Int'l Joint Research] デュースブルクエッセン大学(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] デュースブルクエッセン大学(ドイツ)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Carbon isotope ratio of organic acids in sake and wine by solid-phase extraction combined with LC/IRMS2021

    • Author(s)
      Momoka Suto, Hiroto Kawashima
    • Journal Title

      Analytical and Bioanalytical Chemistry

      Volume: 413 Issue: 2 Pages: 355-363

    • DOI

      10.1007/s00216-020-03003-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of malto-oligosaccharides and related metabolites in rice endosperm during development2020

    • Author(s)
      Yasunori Nakamura, Masami Ono, Momoka Suto, Hiroto Kawashima
    • Journal Title

      Planta

      Volume: 251 Issue: 6

    • DOI

      10.1007/s00425-020-03401-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determination of Organic Acids in Honey by Liquid Chromatography with Tandem Mass Spectrometry2020

    • Author(s)
      Momoka Suto, Hiroto Kawashima, Yasunori Nakamura
    • Journal Title

      Food Analytical Methods

      Volume: 13 Issue: 12 Pages: 2249-2257

    • DOI

      10.1007/s12161-020-01845-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 安定同位体比を用いた食品の産地識別と偽和判定の研究動向2019

    • Author(s)
      川島洋人
    • Journal Title

      Journal of the Mass Spectrometry Society of Japan

      Volume: 67 Pages: 86-91

    • NAID

      130007632535

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stable carbon isotope ratios for organic acids in commercial honey samples2019

    • Author(s)
      Kawashima Hiroto, Suto Momoka, Suto Nana
    • Journal Title

      Food Chemistry

      Volume: 289 Pages: 49-55

    • DOI

      10.1016/j.foodchem.2019.03.053

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heart-cutting two-dimensional liquid chromatography combined with isotope ratio mass spectrometry for the determination of stable carbon isotope ratios of gluconic acid in honey2019

    • Author(s)
      Momoka Suto, Hiroto Kawashima, Nana Suto
    • Journal Title

      Journal of Chromatography A

      Volume: 1608 Pages: 460421-460421

    • DOI

      10.1016/j.chroma.2019.460421

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compound Specific Carbon Isotope Analysis in Sake by LC/IRMS and Brewers’ Alcohol Proportion2019

    • Author(s)
      Momoka Suto, Hiroto Kawashima
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 17635-17635

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 安定同位体比を用いた環境中化学物質の起源推定の研究—最近の農薬類の安定同位体比を用いた研究動向—2018

    • Author(s)
      川島洋人
    • Journal Title

      Japanese Journal of Pesticide Science

      Volume: 43 Issue: 2 Pages: 131-132

    • DOI

      10.1584/jpestics.W18-40

    • NAID

      130007602709

    • ISSN
      2187-0365, 2187-8692
    • Year and Date
      2018-08-20
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determination of carbon isotope ratios for honey samples by means of a liquid chromatography/isotope ratio mass spectrometry system coupled with a post-column pump2018

    • Author(s)
      Kawashima Hiroto, Suto Momoka, Suto Nana
    • Journal Title

      Rapid Communications in Mass Spectrometry

      Volume: 32 Issue: 15 Pages: 1271-1279

    • DOI

      10.1002/rcm.8170

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Online wet oxidation/isotope ratio mass spectrometry method for determination of stable carbon isotope ratios of water-soluble organic carbon in particulate matter2018

    • Author(s)
      Suto Nana, Kawashima Hiroto
    • Journal Title

      Rapid Communications in Mass Spectrometry

      Volume: 32 Issue: 19 Pages: 1668-1674

    • DOI

      10.1002/rcm.8240

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] LC/IRMSを用いた日本酒の純米酒,吟醸酒,普通酒の識別方法の開発2020

    • Author(s)
      須藤百香, 武田恭,川島洋人
    • Organizer
      第68回質量分析総合討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 秋田県産の日本酒中のエタノール,グルコースの炭素安定同位体比分分析2020

    • Author(s)
      須藤百香, 武田恭,川島洋人
    • Organizer
      第80回分析化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 安定した液体クロマトグラフ/安定同位体比質量分析計の改良とはちみつ中の有機成分の高精度分析2020

    • Author(s)
      須藤百香, 川島洋人
    • Organizer
      第80回分析化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ハートカット二次元液体クロマトグラフィー(2D-LC法) を用いたはちみつ中のグルコン酸の炭素安定同位体比分析2019

    • Author(s)
      須藤百香, 川島洋人, 須藤菜那
    • Organizer
      第67回質量分析総合討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Stable carbon isotope ratio measurement of water-soluble organic aerosol using online wet oxidation/isotope ratio mass spectrometry2019

    • Author(s)
      Nana Suto, Hiroto Kawashima
    • Organizer
      7th FIRMS Network Conference 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Stable carbon isotope ratios for carbohydrates and organic acids in commercial honey samples2019

    • Author(s)
      Momoka Suto, Hiroto Kawashima, Nana Suto
    • Organizer
      7th FIRMS Network Conference 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Determination of carbon stable isotope ratios of ethanol and glucose in sake2019

    • Author(s)
      Momoka Suto, Hiroto Kawashima
    • Organizer
      7th FIRMS Network Conference 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 近年の個別化合物の安定同位体測定について~環境分野,食品分野などを例に~2019

    • Author(s)
      川島洋人
    • Organizer
      独立行政法人産業技術総合研究所安全科学研究部門発表会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Source identification for pollution in various environment using stable isotope2019

    • Author(s)
      Hiroto Kawashima
    • Organizer
      Joint International Symposium on Sustainable Development and Environmental issues
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ポストカラム-LC/IRMSを用いたはちみつの化学成分の炭素安定同位体比分析2018

    • Author(s)
      須藤百香, 川島洋人, 須藤菜那
    • Organizer
      第66回質量分析総合討論会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Online wet oxidation/isotope ratio mass spectrometry method for determination of stable carbon isotope ratios of water-soluble organic carbon in PM2.52018

    • Author(s)
      Nana Suto, Hiroto Kawashima
    • Organizer
      AGU fall meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 秋田県立大学システム科学技術学部 環境鑑識学研究室HP

    • URL

      http://www.akita-pu.ac.jp/system/mse/sac/kawa/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Remarks] 秋田県立大学 研究者総覧 川島洋人

    • URL

      http://www.akita-pu.ac.jp/stic/souran/scholar/detail.php?id=208

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 秋田県立大学システム科学技術学部環境鑑識学研究室HP

    • URL

      http://www.akita-pu.ac.jp/system/mse/sac/kawa/index.html

    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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