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Development of dynamic nuclear polarization MRI for metabolic dynamics measurement

Research Project

Project/Area Number 18H03526
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionNagasaki International University

Principal Investigator

Ichikawa Kazuhiro  長崎国際大学, 薬学部, 教授 (10271115)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
KeywordsDNP / MRI / 代謝 / 磁気共鳴 / 核偏極 / イメージング
Outline of Final Research Achievements

The purpose of this study was to build a technological basis for real-time molecular imaging that can be applied to metabolic processes that require time for distribution and metabolism by room temperature dynamic nuclear polarization MRI (DNP-MRI). To this end, we have developed a DNP-MRI probe that can measure other nuclei such as 13C. As a result, it was indicated that 13C DNP-MRI can be performed in a practical time. In addition, it was applied to a tumor or diabetes model of anima. The above results suggest the potential effectiveness as metabolic imaging of 13C DNP-MRI.

Academic Significance and Societal Importance of the Research Achievements

様々な代謝反応により生体機能・恒常性が調節されている。そのため、疾患状態において代謝反応や代謝産物が変化し、診断や治療効果の判断指標として用いられている。リアルタイムで臓器代謝活性を計測できれば、創薬・医療に貢献することが期待できる。極低温核偏極MRIは近年発展している技術であり、前立腺がん等での代謝変化検出が示されているが、測定可能時間が短く応用が限られている。そこで、常温で繰り返し計測を実現し応用範囲を広げることを目的とし、本研究ではその技術基盤を確立した。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (3 results) Book (1 results) Patent(Industrial Property Rights) (1 results)

  • [Int'l Joint Research] West Virginia University(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Dual channel EPR excitation coil array for Overhauser-enhanced MRI2021

    • Author(s)
      A. Enomoto, K. Ichikawa
    • Journal Title

      J Magn Reson

      Volume: 323 Pages: 106890-106890

    • DOI

      10.1016/j.jmr.2020.106890

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic nuclear polarization magnetic resonance imaging and the oxygen-sensitive paramagnetic agent OX63 provide a noninvasive quantitative evaluation of kidney hypoxia in diabetic mice.2019

    • Author(s)
      Kodama Y, Hyodo F, Yamato M, Yasukawa K, Minami Y, Sonoda N, Ogawa Y, Ichikawa K, Inoguchi T
    • Journal Title

      Kidney Int.

      Volume: 96 Issue: 3 Pages: 787-92

    • DOI

      10.1016/j.kint.2019.04.034

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vivo Imaging of the Intra- and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging2018

    • Author(s)
      Yasukawa Keiji、Shigemi Ryota、Kanbe Tomomi、Mutsumoto Yusaku、Oda Fumiko、Ichikawa Kazuhiro、Yamada Ken-Ichi、Tun Xin、Utsumi Hideo
    • Journal Title

      Antioxidants & Redox Signaling

      Volume: in press Issue: 9 Pages: 1147-1161

    • DOI

      10.1089/ars.2017.7336

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 電気泳動を利用したニトロキシルプローブ分離分析法の開発(第3報)2020

    • Author(s)
      榎本彩乃、加藤奈緒、白水直美、田村千尋、市川和洋
    • Organizer
      第59回電子スピンサイエンス学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] DNP-MRI, research in progress2020

    • Author(s)
      K.Ichikawa
    • Organizer
      IMMR seminar, West Virginia University
    • Related Report
      2019 Annual Research Report
  • [Presentation] OMRI可視化範囲拡大のための多チャンネルEPR励起用コイルアレイの開発2019

    • Author(s)
      榎本彩乃、市川和洋
    • Organizer
      第58回電子スピンサイエンス学会年会
    • Related Report
      2019 Annual Research Report
  • [Book] Measuring Oxidants and Oxidative Stress in Biological Systems2020

    • Author(s)
      Kazuhiro Ichikawa,Mayumi Yamato, Tatsuya Naganuma
    • Publisher
      Springer
    • ISBN
      9783030473181
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 計測方法および計測装置2019

    • Inventor(s)
      市川和洋
    • Industrial Property Rights Holder
      市川和洋
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-130425
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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