Development of dynamic nuclear polarization MRI for metabolic dynamics measurement
| Project/Area Number |
18H03526
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90110:Biomedical engineering-related
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2018: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | DNP / MRI / 代謝 / 磁気共鳴 / 核偏極 / イメージング |
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| Outline of Final Research Achievements |
The purpose of this study was to build a technological basis for real-time molecular imaging that can be applied to metabolic processes that require time for distribution and metabolism by room temperature dynamic nuclear polarization MRI (DNP-MRI). To this end, we have developed a DNP-MRI probe that can measure other nuclei such as 13C. As a result, it was indicated that 13C DNP-MRI can be performed in a practical time. In addition, it was applied to a tumor or diabetes model of anima. The above results suggest the potential effectiveness as metabolic imaging of 13C DNP-MRI.
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| Academic Significance and Societal Importance of the Research Achievements |
様々な代謝反応により生体機能・恒常性が調節されている。そのため、疾患状態において代謝反応や代謝産物が変化し、診断や治療効果の判断指標として用いられている。リアルタイムで臓器代謝活性を計測できれば、創薬・医療に貢献することが期待できる。極低温核偏極MRIは近年発展している技術であり、前立腺がん等での代謝変化検出が示されているが、測定可能時間が短く応用が限られている。そこで、常温で繰り返し計測を実現し応用範囲を広げることを目的とし、本研究ではその技術基盤を確立した。
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Report
(4 results)
Research Products
(9 results)
