| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
In this project, we developed new membrane-active antimicrobial agents that act by selectively recognizing and disrupting bacterial cell membranes inspired by natural antimicrobial peptides. We have mimicked the amphiphilic structure of antimicrobial peptides by introducing several cationic functional groups into a hydrophobic macrocyclic molecule as a synthetic molecular framework. The membrane-active antimicrobial agent developed in this study exhibited high antimicrobial activity without developing drug resistance, which is a crucial common issue of conventional antibiotics.
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