| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Outline of Final Research Achievements |
In this study, we focused on the polyion complex (PIC) vesicle PICsome. First, we evaluated the modulation of physical properties by combining cross-linking and chemical modification. In particular, the benefits of silica hybrids in PIC membranes were clarified. In this process, vesicles could be prepared with anionic antimicrobials using guanidinium-functionality-containing polycationes and were useful as an antimicrobial drug delivery system. While investigating the properties of protein-containing vesicles, we discovered the world's first method for fabricating yolk-shell PIC, composed of a unilamellar PICsome and a protein-enriched core and multilamellar PICsomes. In addition, we found that sulfobetaine polymers have excellent permeability through mucosal tissues.
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