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Study on wireless temperature measurement and heating technology for low invasive hyperthermia for malignant tumors.

Research Project

Project/Area Number 18H03545
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90130:Medical systems-related
Research InstitutionAkita University

Principal Investigator

MITOBE Kazutaka  秋田大学, 理工学研究科, 教授 (60282159)

Co-Investigator(Kenkyū-buntansha) 齊藤 元  岩手医科大学, 医学部, 教授 (20323149)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsハイパーサーミア / 誘導加熱 / 低侵襲治療 / ワイヤレス温度計測 / 末期ガン / QOL / 感温磁性体微粒子 / 悪性腫瘍 / 感温磁性体 / 深部温度計測 / 高周波磁場 / 緩和ケア
Outline of Final Research Achievements

In this research, we aim to develop a minimally invasive thermal treatment technology to improve the quality of life (QOL) of patients with end-stage respiratory cancer. In this application, we have developed a 'wireless temperature measurement technology' that uses 'Low Curie Point Ferromagnetic Particles (FILCT)' injected into the tumor as a probe for temperature measurement, and a 'wireless temperature measurement and heating device' for hyperthermia that selectively heats only the tumor to a constant temperature of 45°C from the body surface with a high-frequency magnetic field. Furthermore, envisioning clinical application, we have improved the heating efficiency by doubling the frequency of the applied magnetic field, and implemented a 'magnetic flux application detection unit' that integrates the magnetic field application coil and the detection coil, among other things, we have developed various elemental technologies and made the challenges of this method evident.

Academic Significance and Societal Importance of the Research Achievements

従来のハイパーサーミアでは患部をピンポイントで加温するのが困難であり,治療時に温度センサを刺入しなければならない点が課題であった.本研究は,患部への1回の注射で半年以上の長期間安定して患部に留まり繰り返し発熱が期待できる粒径100μmのインプラントを用いており,且つ,非侵襲的に温度をモニタリングできるハイパーサーミア技術は国内外でも類を見ない.本申請では,磁場印加検知ユニットの最適化,印加磁場の高周波数化を図り,多点温度計測によりインプラント周辺の発熱特性を評価する等,要素技術を構築すると共に,体表面から30mmの深部までハイパーサーミア可能な「ワイヤレス温度計測・加熱装置」を実現した.

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (29 results)

All 2022 2021 2020 2019 2018

All Journal Article (15 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 13 results,  Open Access: 6 results) Presentation (14 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Development of a Learning Support System for Blood Sampling Techniques Using a Magnetic Motion Capture System2022

    • Author(s)
      Masachika Saito, Yukiko Kikuchi, Yukiko Kudo, Makiko Sasaki and Kazutaka Mitobe
    • Journal Title

      IEEJ

      Volume: 17 Issue: 5 Pages: 757-759

    • DOI

      10.1002/tee.23564

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study of an Automatic Temperature Heating System for Hyperthermia of Implants under Water Cooling2021

    • Author(s)
      遠藤 綾人、加藤 裕太、水戸部 一孝
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: Annual59 Issue: Abstract Pages: 527-527

    • DOI

      10.11239/jsmbe.Annual59.527

    • NAID

      130008105479

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] Relationship of temperature distribution and applied magnetic flux frequency for hyperthermia.2021

    • Author(s)
      加藤 裕太、遠藤 綾人、山本 裕和、水戸部 一孝
    • Journal Title

      Transactions of Japanese Society for Medical and Biological Engineering

      Volume: Annual59 Issue: Abstract Pages: 526-526

    • DOI

      10.11239/jsmbe.Annual59.526

    • NAID

      130008105478

    • ISSN
      1347-443X, 1881-4379
    • Related Report
      2021 Annual Research Report
    • Open Access
  • [Journal Article] Development of an Automatic Localization System of Magnetic Particles for Hyperthermia Therapy2021

    • Author(s)
      Tonthat Loi、Mitobe Kazutaka、Yabukami Shin
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 57 Issue: 2 Pages: 1-5

    • DOI

      10.1109/tmag.2020.3008490

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Verification of Protein Extraction Method by Magneto-Ferrite Treatment with EDS Analysis2020

    • Author(s)
      Kotani Suguru、Endo Masaya、Kabir Mahmudul、Mitobe Kazutaka
    • Journal Title

      IEEJ Transactions on Industry Applications

      Volume: 140 Issue: 2 Pages: 128-129

    • DOI

      10.1541/ieejias.140.128

    • NAID

      130007793766

    • ISSN
      0913-6339, 1348-8163
    • Year and Date
      2020-02-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of applied magnetic field on permeability and heating efficiency of multifunctional micro/nano-magnetic particles for hyperthermia therapy2020

    • Author(s)
      Tonthat Loi、Yamamoto Yoshiyuki、Mitobe Kazutaka、Yabukami Shin
    • Journal Title

      AIP Advances

      Volume: 10 Issue: 12 Pages: 125324-125324

    • DOI

      10.1063/9.0000123

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a VR Simulator for Training of Posterior Cervical Spine Fusion Surgery2020

    • Author(s)
      Fujiwara Katsuya、Oikawa Tomoya、Ishikawa Yoshinori、Mitobe Kazutaka
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering

      Volume: 15 Issue: 8 Pages: 1242-1243

    • DOI

      10.1002/tee.23188

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation of Collision Position and Orientation of Elderly Cyclist for Car‐Bicycle Collision Simulation: Factors Causing Accidents on the Side of a Cyclist when Turning Right on Two Lane Straight Road2020

    • Author(s)
      Handa Naoto、Mitobe Kazutaka
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering

      Volume: 15 Issue: 11 Pages: 1705-1707

    • DOI

      10.1002/tee.23240

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of elemental technologies for magnetic hyperthermia in cancer treatment2020

    • Author(s)
      Loi Tonthat, Fumitaka Aki, Kazutaka Mitobe, Shin Yabukami, Yoshiyuki Yamamoto
    • Journal Title

      Proceedings of the 11th Asian Pacific Conference on Medical and Biological Engineering (APCMBE 2020)

      Volume: 1 Pages: 272-277

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feature Extraction of Mild Cognitive Impairment Using a Dual-Task of Drawing and Counting Test2019

    • Author(s)
      Fujiwara Katsuya、Graduate School of Engineering Science, Akita University 1-1 Tegata-gakuen-machi, Akita, Akita 010-8502, Japan、Kano Hidenori、Mitobe Kazutaka
    • Journal Title

      Journal of Advanced Computational Intelligence and Intelligent Informatics

      Volume: 23 Issue: 5 Pages: 874-882

    • DOI

      10.20965/jaciii.2019.p0874

    • NAID

      130007709921

    • ISSN
      1343-0130, 1883-8014
    • Year and Date
      2019-09-20
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Study on Wireless Temperature Measurement Induction Heating System using Magnetic Properties of Mixture of Resovist<sup>®</sup> and Ferromagnetic Implant with Low Curie Temperature2019

    • Author(s)
      Aki Fumitaka、Loi Tonthat、Saito Hajime、Yoshimura Noboru、Mitobe Kazutaka
    • Journal Title

      IEEJ Transactions on Fundamentals and Materials

      Volume: 139 Issue: 1 Pages: 38-44

    • DOI

      10.1541/ieejfms.139.38

    • NAID

      130007542200

    • ISSN
      0385-4205, 1347-5533
    • Year and Date
      2019-01-01
    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermosensitive Ferromagnetic Implant for Hyperthermia Using a Mixture of Magnetic Micro-/Nanoparticles2018

    • Author(s)
      Tonthat Loi、Yamamoto Yoshiyuki、Aki Fumitaka、Saito Hajime、Mitobe Kazutaka
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: - Issue: 7 Pages: 1-6

    • DOI

      10.1109/tmag.2018.2820061

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Study of wireless temperature measurement induction heating system using magnetic properties of au-coated ferromagnetic implant with low Curie temperature2018

    • Author(s)
      Aki Fumitaka、Loi Tonthat、Saito Hajime、Yoshimura Noboru、Mitobe Kazutaka
    • Journal Title

      Electronics and Communications in Japan

      Volume: 101 Issue: 6 Pages: 58-66

    • DOI

      10.1002/ecj.12075

    • NAID

      130006407379

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Examination of the Influence on Precision of the Wireless Temperature Measurement Induction Heating System by 37 °C Constant Temperature Environment2018

    • Author(s)
      Aki Fumitaka、Tonthat Loi、Saito Hajime、Mitobe Kazutaka
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 54 Issue: 6 Pages: 1-3

    • DOI

      10.1109/tmag.2018.2815028

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Thermosensitive Implant for Magnetic Hyperthermia by Mixing Micro-Magnetic and Nano-Magnetic Particles2018

    • Author(s)
      Tonthat Loi、Yamamoto Yoshiyuki、Aki Fumitaka、Saito Hajime、Mitobe Kazutaka
    • Journal Title

      IEEE Transactions on Magnetics

      Volume: 54 Issue: 6 Pages: 1-4

    • DOI

      10.1109/tmag.2018.2821271

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 磁気ハイパーサーミアにおけるワイヤレス温度計測のための最適な検知コイル設置位置の検証2022

    • Author(s)
      佐久間聡, 水戸部一孝
    • Organizer
      生体医工学シンポジウム2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] MR 採血訓練シミュレータのための血管に対する注射針先端相対位置の表示方法の検討2022

    • Author(s)
      伊藤晶, 齋藤正親, 水戸部一孝
    • Organizer
      日本バーチャルリアリティ学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 超音波診断装置用プローブの遠隔操作指導のためのHoloLens2における入力手法の検討2022

    • Author(s)
      鈴木悠太, 水戸部一孝
    • Organizer
      日本バーチャルリアリティ学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 磁気ハイパーサーミアのための誘導加熱用周波数の違いによる昇温特性および温度分布の検討2021

    • Author(s)
      加藤 裕太, 遠藤 綾人, 山本 裕和, 水戸部 一孝
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 水冷条件下の金コート感温磁性体を対象とした磁気ハイパーサーミア用自動定温加熱システムの検証2021

    • Author(s)
      遠藤 綾人, 加藤 裕太, 水戸部 一孝
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 磁気ハイパーサーミアにおける発熱体の昇温分布特性の検討2020

    • Author(s)
      加藤裕太, 山本裕和, 遠藤綾人, 安藝史崇, 水戸部一孝
    • Organizer
      日本生体医工学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 磁気ハイパーサーミア用自動定温加熱システムのためのHigh/Low制御の検討2020

    • Author(s)
      遠藤 綾人, 山本 裕和, 加藤 裕太, 安藝 史崇, 水戸部 一孝
    • Organizer
      日本生体医工学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 電気泳動後のタンパク質を対象としたテラヘルツ透過画像の特徴抽出2020

    • Author(s)
      鍵谷 慧, 水戸部 一孝
    • Organizer
      日本生体医工学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of elemental technologies for magnetic hyperthermia in cancer treatment2020

    • Author(s)
      Loi Tonthat, Fumitaka Aki, Kazutaka Mitobe, Shin Yabukami, Yoshiyuki Yamamoto
    • Organizer
      11th Asian Pacific Conference on Medical and Biological Engineering (APCMBE 2020)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ハイパーサーミア用ワイヤレス温度検知技術のための磁場印加検知ユニットの検討2019

    • Author(s)
      山本 裕和, TON THAT LOI, 安藝 史崇, 水戸部 一孝
    • Organizer
      生体医工学
    • Related Report
      2019 Annual Research Report
  • [Presentation] 磁気ハイパーサーミアのための感温磁性微粒子の位置・温度情報のワイヤレス検知技術に関する研究開発2019

    • Author(s)
      TON THAT LOI, 安藝 史崇, 山本 良之, 齊藤 元, 薮上 信, 水戸部 一孝
    • Organizer
      生体医工学
    • Related Report
      2019 Annual Research Report
  • [Presentation] 金コート感温磁性体を利用したハイパーサーミアのためのワイヤレス温度計測・自動定温加熱システムの構築2019

    • Author(s)
      安藝 史崇, Ton That Loi, 齊藤 元, 山崎 清之, 水戸部 一孝
    • Organizer
      生体医工学
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハイパーサーミア用感温性磁性体の検知可能距離延伸のための磁場印加検知ユニットの検討2018

    • Author(s)
      トンタット ロイ, 高野 渚, 安藝 史崇, 齊藤 元, 水戸部 一孝
    • Organizer
      生体医工学
    • Related Report
      2018 Annual Research Report
  • [Presentation] 電気泳動後のタンパク質のテラヘルツ透過画像の特著抽出法について2018

    • Author(s)
      河端 航大, 水戸部 一孝, 羽渕 友則
    • Organizer
      生体医工学
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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