実験音韻論と脳遺伝学に基づく潜在的な読字困難の指標化

• Project/Area Number: 18H03579
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 2:Literature, linguistics, and related fields
• Research Institution: Tokyo Metropolitan University
• Principal Investigator: 本間 猛 東京都立大学, 人文科学研究科, 教授 (30241045)
• Co-Investigator(Kenkyū-buntansha): 橋本 龍一郎 東京都立大学, 人文科学研究科, 准教授 (00585838) ; 保前 文高 東京都立大学, 人文科学研究科, 教授 (20533417) ; 吉川 武男 国立研究開発法人理化学研究所, 脳神経科学研究センター, 室長 (30249958) ; 川原 繁人 慶應義塾大学, 言語文化研究所(三田), 准教授 (80718792) ; 馬塚 れい子 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (00392126)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000); Fiscal Year 2021: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000); Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000); Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000); Fiscal Year 2018: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 読字困難 / 実験音韻論 / 音韻意識 / 言語脳科学 / 言語遺伝学

Outline of Annual Research Achievements

○本研究では、読字困難を生じさせる原因を実験音韻論、言語脳科学、および遺伝学の手法を用い、多角的に迫ることを目指した。○音声言語の獲得は、容易であるが、文字を読むこと (読字)は、困難を伴うことがある。発達性の失読症とは、学習環境などが十分でかつ視覚や空間認知などに支障がなくても、読字に困難を来す症状をいう。この研究課題では、読字の困難さを読めるか否かと二分するのではなく、読字の困難さを分布がある「程度」として捉えることによって潜在的な読字困難の存在を示した上で、その程度差を生じる脳遺伝学的要因をふまえて、中核となる言語知識(音韻意識)を明らかにする実験音韻論を構築することを目指した。具体的には、潜在的な読字困難を連続体(スペクトラム)と捉え、その要因を明らかにして、改善に向けた方法を提案を目標とした。 ○まず、1) [読字行動の指標化]スペクトラムとしての読字困難の程度分布を小学生群を対象にした行動調査の結果から作成して潜在的な困難を見いだし、2)[脳波の特徴抽出] 同じ小学生群 から得た脳波の特徴を2次元座標上で表現して潜在的な読字困難がどのように表現されるかを示した上で、3)[遺伝子多型の抽出] その群が示す遺伝子多型の特徴を組み合わせとして捉えることを目指した。この3点のうち、「遺伝子多型の抽出」については、読字に関連する可能性のある遺伝子をいくつか選び、解析がある程度進んだ。「読字行動の指標化」および「脳波の特徴抽出」については、検討事項の洗い出しを行った。しかしながら、新型コロナウイルス感染症の影響と実験を行う研究室が建物の外壁工事の影響による雨漏りで実験機器が水没するなどの影響もあり、計画していた実験が十分に行えなかった。

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] A cross-linguistic, sound symbolic relationship between labial consonants, voiced plosives, and Pokemon friendship (2023)
  • Author(s): Kilpatrick Alexander、Cwiek Aleksandra、Lewis Eleanor、Kawahara Shigeto
  • Journal Title: Frontiers in Psychology Volume: 14 Pages: 1-11
  • DOI: 10.3389/fpsyg.2023.1113143
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Limits on gestural reorganization following vowel deletion: The case of Tokyo Japanese (2023)
  • Author(s): Shaw Jason、Kawahara Shigeto
  • Journal Title: Laboratory Phonology Volume: 14
  • DOI: 10.16995/labphon.8543
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lyman’s Law can count only up to two (2023)
  • Author(s): Kawahara Shigeto、Kumagai Gakuji
  • Journal Title: Volume 14 Volume: 14 Issue: 1 Pages: 1-27
  • DOI: 10.16995/labphon.9335
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rendaku is not blocked by two nasal consonants: A reply to Kim (2022) (2023)
  • Author(s): Kawahara Shigeto、Kumagai Gakuji
  • Journal Title: Glossa: a journal of general linguistics Volume: 8 Issue: 1 Pages: 1-16
  • DOI: 10.16995/glossa.9550
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subcortical volumetric alterations in four major psychiatric disorders: A mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification (2023)
  • Author(s): Hashimoto Ryuichiro (among 47 authors)
  • Journal Title: Molecular Psychiatry Volume: 28 Pages: 5206-5216
  • DOI: 10.21203/rs.3.rs-2182255/v1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Speaking rate normalization across different talkers in the perception of Japanese stop and vowel length contrasts (2022)
  • Author(s): Kawahara Shigeto、Kato Misaki、Idemaru Kaori
  • Journal Title: JASA Express Letters Volume: 2 Issue: 3
  • DOI: 10.1121/10.0009793
  • Peer Reviewed / Open Access
• [Journal Article] How Russian speakers express evolution in Pok?mon names: an experimental study with nonce words (2022)
  • Author(s): Kumagai Gakuji、Kawahara Shigeto
  • Journal Title: Linguistics Vanguard Volume: 8 Issue: 1 Pages: 15-27
  • DOI: 10.1515/lingvan-2021-0101
  • Peer Reviewed / Open Access
• [Journal Article] Oscillator decomposition of infant fNIRS data (2022)
  • Author(s): Matsuda, T., Homae, F., Watanabe, H., Taga, G., & Komaki, F.
  • Journal Title: PLoS computational biology Volume: - Issue: 3 Pages: 1-31
  • DOI: 10.1371/journal.pcbi.1009985
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Individual variability in the nonlinear development of the corpus callosum during infancy and toddlerhood: a longitudinal MRI analysis (2022)
  • Author(s): Tsuzuki, D., Taga, G., Watanabe, H., & Homae, F.
  • Journal Title: Brain Structure and Function Volume: - Issue: 6 Pages: 1-19
  • DOI: 10.1007/s00429-022-02485-y
  • Peer Reviewed / Open Access
• [Journal Article] Spontaneous variability predicts compensative motor response in vocal pitch control (2022)
  • Author(s): Ryosuke O. Tachibana, Mingdi Xu, Ryu-ichiro Hashimoto, Fumitaka Homae & Kazuo Okanoya
  • Journal Title: Scientific Reports Volume: 12(1), 17740 Issue: 1 Pages: 17740-17740
  • DOI: 10.1038/s41598-022-22453-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 音象徴と言語学ー教育と研究 (2021)
  • Author(s): 川原繁人
  • Journal Title: 日本認知言語学会論文集 Volume: 21 Pages: 489-491
  • Peer Reviewed
• [Journal Article] What voiced obstruents symbolically represent in Japanese: evidence from the Pokemon universe (2021)
  • Author(s): Kawahara Shigeto、Kumagai Gakuji
  • Journal Title: Journal of Japanese Linguistics Volume: 37 Issue: 1 Pages: 3-24
  • DOI: 10.1515/jjl-2021-2031
  • Peer Reviewed / Open Access
• [Journal Article] Pokemon meets psychology and linguistics: Experimental and theoretical exploration of the bouba-kiki effect (2021)
  • Author(s): Kawahara Shigeto
  • Journal Title: Phonological Studies Volume: 24 Pages: 77-84
  • NAID: 40022530788
  • Peer Reviewed
• [Journal Article] How to express evolution in English Pok?mon names (2021)
  • Author(s): Kawahara Shigeto、Moore Jeff
  • Journal Title: Linguistics Volume: 59 Issue: 3 Pages: 577-607
  • DOI: 10.1515/ling-2021-0057
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessing the prosodic licensing of wh-in-situ in Japanese (2021)
  • Author(s): Kawahara Shigeto、Shaw Jason A.、Ishihara Shinichiro
  • Journal Title: Natural Language & Linguistic Theory Volume: 40 Issue: 1 Pages: 103-122
  • DOI: 10.1007/s11049-021-09504-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. (2021)
  • Author(s): Ohnishi T, Kiyama Y, Arima-Yoshida F, Kadota M, Ichikawa T, Yamada K, Watanabe A, Ohba H, Tanaka K, Nakaya A, Horiuchi Y, Iwayama Y, Toyoshima M, Ogawa I, Shimamoto-Mitsuyama C, Maekawa M, Balan S, Arai M, Miyashita M, Toriumi K, et al.
  • Journal Title: EMBO Mol Med Volume: 13 Issue: 4
  • DOI: 10.15252/emmm.202012574
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Role of an Atypical Cadherin Gene, Cdh23 in Prepulse Inhibition and Implication of CDH23 in Schizophrenia (2021)
  • Author(s): Balan S, Ohnishi T, Watanabe A, Ohba H, Iwayama Y, Toyoshima M, Hara T, Hisano Y, Miyasaka Y, Toyota T, Shimamoto-Mitsuyama C, Maekawa M, Numata S, Ohmori T, Shimogori T, Kikkawa Y, Hayashi T, Yoshikawa T
  • Journal Title: Schizophr Bull Volume: - Issue: 4 Pages: 1190-1200
  • DOI: 10.1093/schbul/sbab007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exploring the nature of cumulativity in sound symbolism: Experimental studies of Pokemonastics with English speakers (2021)
  • Author(s): Kawahara Shigeto、Breiss Canaan
  • Journal Title: Laboratory Phonology: Journal of the Association for Laboratory Phonology Volume: 12 Issue: 1
  • DOI: 10.5334/labphon.280
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sound symbolism in Brazilian Portuguese Pokemon names: Evidence for cross-linguistic similarities and differences (2021)
  • Author(s): Mahayana C. Godoy, Andre Lucas Gomes, Gakuji Kumagai, Shigeto Kawahara
  • Journal Title: Journal of Portuguese Linguistics Volume: 20(1) Issue: 1 Pages: 1-23
  • DOI: 10.5334/jpl.257
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pokemon meets psychology and linguistics: Experimental and theoretical exploration of the boba-kiki effect (2021)
  • Author(s): Kawahara, Shigeto
  • Journal Title: Phonological Studies Volume: 21 Pages: 77-84
  • Peer Reviewed
• [Journal Article] Brain activations while processing degraded speech in adults with autism spectrum disorder (2021)
  • Author(s): Lin, IF., Itahashi, T., Kashino, M., Kato, N., & Hashimoto, R.
  • Journal Title: Neuropsychologia Volume: 152 Pages: 1-9
  • DOI: 10.1016/j.neuropsychologia.2021.107750
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A wug-shaped curve in sound symbolism: the case of Japanese Pokemon names (2020)
  • Author(s): Kawahara Shigeto
  • Journal Title: Phonology Volume: 37 Issue: 3 Pages: 383-418
  • DOI: 10.1017/s0952675720000202
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the role of fatty acid-binding protein 7 in controlling schizophrenia-relevant phenotypes using newly established knockout mice (2019)
  • Author(s): Shimamoto-Mitsuyama Chie、Ohnishi Tetsuo、Balan Shabeesh、Ohba Hisako、Watanabe Akiko、Maekawa Motoko、Hisano Yasuko、Iwayama Yoshimi、Owada Yuji、Yoshikawa Takeo
  • Journal Title: Schizophrenia Research Volume: - Pages: 52-59
  • DOI: 10.1016/j.schres.2019.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABAA receptor trafficking and social behavior (2019)
  • Author(s): Hui Kelvin K.、Takashima Noriko、Watanabe Akiko、Chater Thomas E.、Matsukawa Hiroshi、Nekooki-Machida Yoko、Nilsson Per、Endo Ryo、Goda Yukiko、Saido Takaomi C.、Yoshikawa Takeo、Tanaka Motomasa
  • Journal Title: Science Advances Volume: 5 Issue: 4
  • DOI: 10.1126/sciadv.aau8237
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation (2019)
  • Author(s): Ma Min、Ren Qian、Yang Jun、Zhang Kai、Xiong Zhongwei、Ishima Tamaki、Pu Yaoyu、Hwang Sung Hee、Toyoshima Manabu、Iwayama Yoshimi、Hisano Yasuko、Yoshikawa Takeo、Hammock Bruce D.、Hashimoto Kenji
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 116 Issue: 14 Pages: 7083-7088
  • DOI: 10.1073/pnas.1819234116
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes (2019)
  • Author(s): Vadgama Nirmal、Pittman Alan、Simpson Michael、Nirmalananthan Niranjanan、Murray Robin、Yoshikawa Takeo、De Rijk Peter、Rees Elliott、Kirov George、Hughes Deborah、Fitzgerald Tomas、Kristiansen Mark、Pearce Kerra、Cerveira Eliza、Zhu Qihui、Zhang Chengsheng、Lee Charles、Hardy John、Nasir Jamal
  • Journal Title: European Journal of Human Genetics Volume: 27 Issue: 7 Pages: 1121-1133
  • DOI: 10.1038/s41431-019-0376-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis (2019)
  • Author(s): Toyoshima M, Jiang X, Ogawa T, Ohnishi T, Yoshihara S, Balan S, Yoshikawa T, Hirokawa N.
  • Journal Title: Life Sci Alliance Volume: 2 Issue: 5 Pages: e201900478-e201900478
  • DOI: 10.26508/lsa.201900478
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology. (2019)
  • Author(s): Ide M, et al. .... Kimura H, Yoshikawa T.
  • Journal Title: EMBO Mol Med. Volume: 11(12) Issue: 12
  • DOI: 10.15252/emmm.201910695
  • NAID: 120007132855
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of overt speech on lexical-semantic processes during picture naming (2019)
  • Author(s): Park, E. & Homae, F.
  • Journal Title: 日本認知科学会第36回大会発表予稿集 Volume: －
  • Peer Reviewed
• [Journal Article] 形式音韻論と英語の音節構造 (2019)
  • Author(s): 本間猛
  • Journal Title: 人文学報 Volume: 515-6 Pages: 41-52
  • NAID: 40022077535
• [Journal Article] Thiosulfate promotes hair growth in mouse model (2018)
  • Author(s): Maekawa Motoko、Ohnishi Tetsuo、Balan Shabeesh、Hisano Yasuko、Nozaki Yayoi、Ohba Hisako、Toyoshima Manabu、Shimamoto Chie、Tabata Chinatsu、Wada Yuina、Yoshikawa Takeo
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 83 Issue: 1 Pages: 114-122
  • DOI: 10.1080/09168451.2018.1518705
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia. (2018)
  • Author(s): Balan S, Toyoshima M, Yoshikawa T
  • Journal Title: Neurobiology of Disease Volume: 印刷中 Pages: 104162-104162
  • DOI: 10.1016/j.nbd.2018.04.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sound symbolic patterns in Pokemon names (2018)
  • Author(s): Kawahara, Shigeto, Atsushi Noto, and Gakuji Kumagai
  • Journal Title: Phonetica Volume: 75 Issue: 3 Pages: 219-244
  • DOI: 10.1159/000484938
  • Peer Reviewed / Open Access
• [Journal Article] Assessing surface phonological specification through simulation and classification of phonetic trajectories (2018)
  • Author(s): Shaw Jason A.、Kawahara Shigeto
  • Journal Title: Phonology Volume: 35 Issue: 3 Pages: 481-522
  • DOI: 10.1017/s0952675718000131
• [Presentation] "Trochaic clusters in English" (2022)
  • Author(s): Honma Takeru
  • Organizer: The 8th International Conference on Phonology and Morphology
  • Int'l Joint Research / Invited
• [Presentation] Checking lexical relation between verbs and objects required for the processing of case information: An ERP study. (2020)
  • Author(s): Horiguchi, Y. & Homae, F.
  • Organizer: The twelfth meeting of the Society for the Neurobiology of Language, Online
  • Int'l Joint Research
• [Presentation] 『エンドフェノタイプから探る統合失調症の生物学－Genetics vs. Epigenetics－』 (2020)
  • Author(s): 吉川武男
  • Organizer: 第50回日本神経精神薬理学会年会他合同年会
  • Invited
• [Presentation] Pokemonastics: what we are doing and why we are doing it (2020)
  • Author(s): Kawahara, Shigeto
  • Organizer: Zentrum Allgemeine Sprachwissenschaft
  • Int'l Joint Research / Invited
• [Presentation] IERS Workshop: Current trends in the interface between phonetics and phonology (2020)
  • Author(s): Kawahara, Shigeto
  • Organizer: Interfacing sound symbolism with formal phonology
  • Int'l Joint Research / Invited
• [Presentation] プリキュア名と両唇音の音象徴II：実験的検証 (2020)
  • Author(s): 川原繁人
  • Organizer: 日本音声学会
• [Presentation] 音象徴と言語学ー教育と研究 (2020)
  • Author(s): 川原繁人
  • Organizer: 日本認知言語学会
  • Invited
• [Presentation] Exploring the nature of cumulativity through sound symbolism (2020)
  • Author(s): Kawahara, Shigeto and Canaan Breiss
  • Organizer: Annual meeting of phonology
  • Int'l Joint Research
• [Presentation] MaxEnt harmonic Grammar and sound symbolism: Two case studies from English (2020)
  • Author(s): Kawahara, Shigeto and Canaan Breiss
  • Organizer: 日本音韻論学会
• [Presentation] 吃音中核症状の責任領域の探求ー経頭蓋直流電気刺激法による予備的検討 (2019)
  • Author(s): 矢田康人・橋本龍一郎
  • Organizer: 第64回日本音声言語医学会総会・学術講演会
• [Presentation] Effect of transcranial direct current stimulation to language-related regions on speech motor control. (2019)
  • Author(s): Matsuhashi, K., Yada, Y., & Hashimoto, R.
  • Organizer: Neuro2019
  • Int'l Joint Research
• [Presentation] 音とことばのふしぎな世界 2019:プリキュア、ポケモンから日本語ラップまで (2019)
  • Author(s): 川原繁人
  • Organizer: 愛知大学コロキアム
  • Invited
• [Presentation] 英語の音素配列論と音韻論的思考法 (2019)
  • Author(s): 本間猛
  • Organizer: 上智大学音声学研究室講演会
  • Invited
• [Presentation] 脳機能画像にもとづく発達障害の生物学的指標の探索: 安静時機能ネットワークを中心に (2019)
  • Author(s): 橋本龍一郎
  • Organizer: 国立リハビリテーションセンター研究所「発達障害者の言語：階層性と意図共有の接点」
  • Int'l Joint Research / Invited
• [Presentation] 見て聞いてつながる (2019)
  • Author(s): 保前文高
  • Organizer: 首都大学東京 言語科学教室 第4回 発達脳フォーラム
• [Presentation] 言葉遊びの音韻論 (2019)
  • Author(s): 本間猛
  • Organizer: 東京音韻論研究会
  • Invited
• [Presentation] 音韻理論における有標性について (2019)
  • Author(s): 本間猛
  • Organizer: 科学研究費補助金 基盤研究(B) 「隣接諸科学乗り入れ型の手法による音韻理論の外的・内的検証の研究 研究成果発表会
• [Presentation] Acquisition of the takete-maluma effects by Japanese speaker: A cross-sectional study (2018)
  • Author(s): Kobayashi, Yukino, Miwa Isobe, Shigeto Kawahara, Tomoko Monou, Reiko Okabe, Kazuhiro Abe, Yasuyo Minagawa
  • Organizer: MAPLL × TCP × TL × TaLK
  • Int'l Joint Research
• [Presentation] 名付けの不思議と音声の不思議 (2018)
  • Author(s): 川原繁人
  • Organizer: 日本大学国際教養学科第二回学術講演会
  • Invited
• [Presentation] 幼児はポケモン名付けに音象徴を用いるか-ポケモンネーミングにおける母音と有声阻害音の効果- (2018)
  • Author(s): 小林ゆきの、磯部美和、桃生朋子、岡部玲子、川原繁人
  • Organizer: 日本言語学会第156回大会、東京大学本郷キャンパス
• [Book] なぜ、おかしの名前はパピプペポが多いのか？ 言語学者、小学生の質問に本気で答える (2023)
  • Author(s): 川原繁人
  • Total Pages: 287
  • Publisher: ディスカヴァー・トゥエンティワン
  • ISBN: 9784799329757
• [Book] 音声学者、娘とことばの不思議に飛び込む～プリチュアからカピチュウ、おっけーぐるぐるまで～ (2022)
  • Author(s): 川原繁人
  • Total Pages: 280
  • Publisher: 朝日出版社
  • ISBN: 9784255012759
• [Book] フリースタイル言語学 (2022)
  • Author(s): 川原繁人
  • Total Pages: 352
  • Publisher: 大和書房
  • ISBN: 9784479393894
• [Book] 言語学者、外の世界へ羽ばたく (2022)
  • Author(s): 川原繁人
  • Total Pages: 167
  • Publisher: 教養検定会議
  • ISBN: 9784910292021
• [Book] 個性学入門 : 個性創発の科学 (2021)
  • Author(s): 保前, 文高, 大隅, 典子
  • Total Pages: 232
  • Publisher: 朝倉書店
  • ISBN: 9784254102956
• [Book] ビジュアル音声学 (2018)
  • Author(s): 川原 繁人
  • Total Pages: 240
  • Publisher: 三省堂
  • ISBN: 9784385365329