| Budget Amount *help |
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2020: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2019: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2018: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
|
|---|
| Outline of Final Research Achievements |
DREADDs（Designer Receptors Exclusively Activated by Designer Drugs） were expressed in the lateral prefrontal neurons of Japanese monkeys, which selectively project to the striatum of basal ganglia. The DREADDs were activated by the CNO and then, the information transmission from the lateral prefrontal cortex (LPFC) to the striatum was blocked while monkeys were performing the delayed response task with asymmetric reward. This manipulation led to the decrease in the inhibitory control of behavior but didn't affect the working memory function. Now the similar manipulation was applied to the connection from the LPFC to the parietal cortex. We are comparing the effect of blocking the LPFC-parietal connection with that of blocking the LPFC-striatum connection.
|
