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Presence and chirality of sugars formed in the early solar system: a new origin of biomolecule

Research Project

Project/Area Number 18H03728
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 17:Earth and planetary science and related fields
Research InstitutionTohoku University

Principal Investigator

Furukawa Yoshihiro  東北大学, 理学研究科, 准教授 (00544107)

Co-Investigator(Kenkyū-buntansha) 大河内 直彦  国立研究開発法人海洋研究開発機構, 海洋機能利用部門, 部門長 (00281832)
力石 嘉人  北海道大学, 低温科学研究所, 教授 (50455490)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Keywords糖 / リボース / 隕石 / アミノ酸 / 生命の起源 / 小惑星 / 初期太陽系 / 地球外 / 有機物 / 光学異性体
Outline of Final Research Achievements

Sugars are important constituents of life, but have never found in extraterrestrial samples and space. In this research we found extraterrestrial ribose and related sugars from meteorites and published the paper in PNAS. With laboratory experiments, the synthetic reaction of sugars was found to be formose-type reaction and this reaction was found to be a major synthetic reaction of meteorite organic compounds that provided large carbon isotope differences between amino acids and insoluble organic matter.
We also succeeded in developing the protocol of chiral analysis of the sugars and investigated the chirality of meteorite sugars.

Academic Significance and Societal Importance of the Research Achievements

生命を構成する糖は、これまでに地球外や地球外物質からは見つかっていなかった。本研究で隕石から地球外のリボースを発見したことは、生命の材料となる糖が、生命誕生前の地球に、地球外からもたらされていたことを示す証拠となった。また、隕石に含まれる糖の生成反応であるホルモース型反応が隕石有機物の主要生成反応であったことを、模擬実験で生成したアミノ酸と不溶性有機物の炭素同位体比分析から明らかにした。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (15 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (3 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (9 results) (of which Invited: 4 results)

  • [Int'l Joint Research] NASA Goddard Space Flight Center(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] NASA(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] NASA(米国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Investigations on the formation and delivery of meteorite organic matter based on the carbon isotope compositions2021

    • Author(s)
      古川善博
    • Journal Title

      低温科学

      Volume: 79 Pages: 59-67

    • DOI

      10.14943/lowtemsci.79.59

    • ISSN
      1880-7593
    • Year and Date
      2021-03-20
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of 13C-enriched amino acids with 13C-depleted insoluble organic matter in a formose-type reaction in the early solar system2021

    • Author(s)
      Yoshihiro Furukawa, Yoshinari Iwasa, Yoshito Chikaraishi
    • Journal Title

      Science Advances

      Volume: 7 Issue: 18

    • DOI

      10.1126/sciadv.abd3575

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extraterrestrial ribose and other sugars in primitive meteorites2019

    • Author(s)
      Furukawa Yoshihiro、Chikaraishi Yoshito、Ohkouchi Naohiko、Ogawa Nanako O.、Glavin Daniel P.、Dworkin Jason P.、Abe Chiaki、Nakamura Tomoki
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 49 Pages: 24440-24445

    • DOI

      10.1073/pnas.1907169116

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 生命分子の起源を探る2021

    • Author(s)
      古川善博
    • Organizer
      第1回FoS公開シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 隕石有機物の主要生成反応: 炭素同位体組成からの制約2020

    • Author(s)
      古川善博,岩佐義也,力石嘉人
    • Organizer
      日本惑星科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 炭素同位体比に制約された隕石有機物生成反応の再現2020

    • Author(s)
      古川善博,岩佐義也,力石嘉人
    • Organizer
      日本地球化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 隕石からの糖の検出: 宇宙からの生命材料の供給2020

    • Author(s)
      古川善博
    • Organizer
      日本尿路結石症学会第 30 回学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 宇宙での糖の生成と地球への運搬2020

    • Author(s)
      古川善博
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Investigation of sugars in meteorites2019

    • Author(s)
      Yoshihiro Furukawa
    • Organizer
      JPGU 2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 地球化学会2018

    • Author(s)
      古川善博
    • Organizer
      始原的隕石中の糖の探索
    • Related Report
      2018 Annual Research Report
  • [Presentation] 初期地球における糖の起源2018

    • Author(s)
      古川善博
    • Organizer
      生命の起源および進化学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 惑星科学会2018

    • Author(s)
      古川善博
    • Organizer
      始原的隕石中の糖の探索
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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