| Budget Amount *help |
¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
Fiscal Year 2022: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2021: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2020: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2019: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2018: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
To realize an ultra-thin microphotonic device that can be minimally invasively and dispersively implanted in the mouse brain and enables optical manipulation and measurement of biological functions, we fabricated a brain-implantable flexible microimaging device and a brain-implantable flexible optical stimulation device, implanted them in the mouse brain, and demonstrated imaging and optical stimulation under free-running conditions. We demonstrated imaging and optical stimulation of the brain under free-running conditions. In addition, we have conducted optical manipulation and measurement of neural circuits by microphotonic devices dispersively implanted in the mouse brain, and have analyzed dopamine neural responses to nicotine administration in detail by implanting microphotonic devices in the VTA and nucleus accumbens, and have demonstrated pain responses to formalin injection. The pain response to injections of formalin was analyzed using devices implanted in the DRC and ACC.
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