| Budget Amount *help |
¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2021: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2020: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2019: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000)
Fiscal Year 2018: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Outline of Final Research Achievements |
We developed an in silico human model to visualize health risk associated with exposure to contaminated indoor air. In particular, we developed numerical models that can predict inhalation exposure in respiratory tract and dermal exposure by deposition of gas-phase contaminant. Specifically, (1)we newly developed physiologically based pharmacokinetic/toxicokinetic models that reproduce inhalation exposure and dermal exposure, and (2)these models were integrated into the in silico human model that precisely reproduced body surface and respiratory tract geometry. (3) We also established a comprehensive analysis method for human-environment systems that integrates in silico human model and computational fluid dynamics (CFD) technique. Finally, (4)we conducted demonstrative analyses for e-cigarette smoking in an indoor environment and showed quantitatively the potential effects of e-cigarette smoking on local tissue dosimetry and the deterioration of indoor air quality.
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