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Novel approach for spectroscopic molecule detection: Pioneering multicolor multiphoton photothermal spectroscopy

Research Project

Project/Area Number 18H03915
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 34:Inorganic/coordination chemistry, analytical chemistry, and related fields
Research InstitutionKyushu University

Principal Investigator

Harata Akira  九州大学, 総合理工学研究院, 教授 (90222231)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2020: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2018: ¥24,440,000 (Direct Cost: ¥18,800,000、Indirect Cost: ¥5,640,000)
Keywords2色2光子励起 / 光熱変換 / 非蛍光性化学種 / 超高感度検出 / 紫外レーザー分光 / 多色多光子吸収 / ヘテロダイン検出 / 偏光依存性 / 光音響 / 偏光特性 / 円偏光 / 溶液物理化学
Outline of Final Research Achievements

Many important and trace amounts of biological and environmental species in liquid solutions are non-fluorescent and absorb light only in the ultraviolet region. A general-purpose method that can detect them without chemical modification and with high sensitivity is required. A label-free and ultra-sensitive detection technique for non-fluorescent chemical species that involves versatility, high sensitivity, and species selectivity is designed and examined by further improving a deep-UV photoexcitation photothermal heterodyne-interferometer. It has been demonstrated that deep UV absorption bands are photoexcited by two-color two-photon excitation using an all-solid-state laser as an excitation light source, and that thermal lens spectra and photoacoustic spectra are successfully measured. Performance of a separation-detection system with high-performance liquid-chromatography and the photothermal heterodyne-interferometer is reported.

Academic Significance and Societal Importance of the Research Achievements

新しい計測技術が、科学技術の発展の礎となる例、また、安全・安心な社会を実現する上での実用的重要性を示す例には事欠かない。蛍光性化学種の高感度検出がもたらした技術革新は顕著である。一方、化学修飾に適さない非蛍光性化学種には敢えて触れないことも一部習慣化されており、科学技術の課題でもある。本研究は、重要性が高く微量な生体・環境関連の溶液中化学種の無修飾・高感度検出において、次の2つの点を実証したことに重要な意義がある。2色2光子励起により深紫外吸収帯を励起できること。光熱変換検出により無蛍光性化学種が高感度分離・検出できること。これらは、非蛍光性化学種の汎用的な高感度検出実現に貢献するものである。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (25 results)

All 2023 2022 2021 2020 2019 2018 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 6 results) Remarks (5 results)

  • [Journal Article] Two-photon photoacoustic spectroscopy of liquid solutions under degenerate and non-degenerate laser excitation2023

    • Author(s)
      Shiori Sakurai, Miki Isoda, Akira Harata
    • Journal Title

      Japanese journal of applied physics

      Volume: 62 Issue: SJ Pages: SJ1001-SJ1001

    • DOI

      10.35848/1347-4065/acb063

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methodology for measuring two-color two-photon photoacoustic spectra of chemical species in liquid solutions2022

    • Author(s)
      Shiori Sakurai, Miki Isoda, Akira Harata
    • Journal Title

      Proceedings of Symposium on Ultrasonic Electronics

      Volume: 43

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a photoacoustic spectrometer for two-photon absorption using a femtosecond laser2022

    • Author(s)
      Kazuki Tomimaru, Miki Isoda, Akira Harata
    • Journal Title

      Proceedings of Symposium on Ultrasonic Electronics

      Volume: 43

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultraviolet and Deep-Ultraviolet Excitation Photothermal Heterodyne Interferometer Combined with Semi-Micro HPLC2021

    • Author(s)
      Miki Isoda, Toshihiko Abe, Kai Aoki, Akira Harata
    • Journal Title

      Analytical Sciences

      Volume: 37 Issue: 6 Pages: 911-916

    • DOI

      10.2116/analsci.20P328

    • NAID

      130008050695

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2021-06-10
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ultraviolet-Excitation Photothermal Heterodyne Interferometer as a Micro-HPLC Detector2019

    • Author(s)
      Miki ISODA, Makoto FUKUMA, Akira HARATA
    • Journal Title

      Analytical Sciences

      Volume: 35 Issue: 12 Pages: 1311-1315

    • DOI

      10.2116/analsci.19P190

    • NAID

      130007760259

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2019-12-10
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 液体中化学種の二色二光子光音響スペクトル測定法の開発2022

    • Author(s)
      櫻井 栞 礒田 美紀 原田 明
    • Organizer
      第 43 回 超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] フェムト秒レーザーを用いた二光子吸収の光音響分光分析装置の開発2022

    • Author(s)
      冨丸 和希 礒田 美紀 原田 明
    • Organizer
      第 43 回 超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] グラジエント溶離セミミクロHPLC/紫外光熱変換ヘテロダイン干渉検出による無標識ニトロ多環芳香族炭化水素の高感度分離分析2022

    • Author(s)
      原田 明、木原 香澄、山中 雄太、礒田 美紀
    • Organizer
      日本分析化学会71年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 光音響検出による液体試料の二光子吸収スペクトル測定法の開発2022

    • Author(s)
      櫻井 栞 礒田 美紀 原田 明
    • Organizer
      第59回化学関連支部合同九州大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] フェムト秒レーザー照射による二光子吸収の光音響分光検出による分析装置の開発2022

    • Author(s)
      冨丸 和希 礒田 美紀 原田 明
    • Organizer
      第59回化学関連支部合同九州大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] セミミクロHPLC/光熱変換ヘテロダイン干渉分光法を用いた環境関連物質の無標識・高感度分離分析2021

    • Author(s)
      木原 香澄、礒田 美紀、原田 明
    • Organizer
      日本分析化学会70年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] セミミクロHPLC/光熱変換ヘテロダイン干渉分光法を用いた生体・環境関連物質の無標識・高感度分離分析2021

    • Author(s)
      木原 香澄、礒田 美紀、原田 明
    • Organizer
      第58回化学関連支部合同九州大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 2色2光子熱レンズ検出と2光子吸収スペクトル2020

    • Author(s)
      原田 明、上戸 あいら、小平田 新十郎、礒田 美紀
    • Organizer
      日本分析化学会69年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of Laser Excitation Thermal Lens Spectroscopy by Deep Ultraviolet Excitation (LETLS-213)2019

    • Author(s)
      Aira KAMITO, Miki ISODA, Akira HARATA
    • Organizer
      5th International Exchange and Innovation Conference on Engineering & Sciences
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Multiphoton Excitation Thermal Lens Spectroscopy for Label-Free and High-Sensitive Detection2019

    • Author(s)
      Shinjuro KOHIRATA, Miki ISODA, Akira HARATA
    • Organizer
      第40回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deep Ultraviolet Excitation Thermal Lens Spectroscopy2019

    • Author(s)
      KAMITO Aira, ISODA Miki, HARATA Akira
    • Organizer
      21st Cross Straits Symposium on Energy and Environmental Science and Technology (CSS-EEST)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HPLC/光熱変換ヘテロダイン干渉法を用いたニトロ多環芳香族炭化水素の高感度分析2019

    • Author(s)
      礒田 美紀、安倍 聡彦、原田 明
    • Organizer
      総合技術研究会2019九州大学
    • Related Report
      2018 Annual Research Report
  • [Presentation] Development of Thermal Lens Spectroscopy by Deep Ultraviolet Excitation for Label-Free and High-Sensitive Detection for Micro-Analysis2019

    • Author(s)
      KOHIRATA, Shinjuro; ISODA,Miki; HARATA, Akira
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイクロ流路デバイスを用いた深紫外光励起熱レンズ分光法の開発2018

    • Author(s)
      岩坂 諒、原田 明、磯田 美紀
    • Organizer
      第55回化学関連支部合同九州大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] セミミクロHPLC/紫外光励起光熱変換検出法を用いたニトロ多環芳香族炭化水素の高感度分析2018

    • Author(s)
      原田 明、安部 聡彦、岩坂 諒、礒田 美紀
    • Organizer
      日本分析化学会第67年会
    • Related Report
      2018 Annual Research Report
  • [Remarks] 九州大学大学院総合理工学府原田・薮下研究室

    • URL

      https://www.mm.kyushu-u.ac.jp/lab_07/

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] 九州大学研究者情報「原田 明」

    • URL

      https://hyoka.ofc.kyushu-u.ac.jp/search/details/K000367/index.html

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] 研究者プロファイリングツール 九州大学Pure

    • URL

      https://kyushu-u.pure.elsevier.com/ja/persons/akira-harata

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] 九州大学大学院総合理工学府原田・薮下研究室

    • URL

      http://www.mm.kyushu-u.ac.jp/lab_07/

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report
  • [Remarks] 「原田 明」教育研究関連のデータベース

    • URL

      http://www.mm.kyushu-u.ac.jp/lab_07/members/harata/AHDB_01.html

    • Related Report
      2019 Annual Research Report 2018 Annual Research Report

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Published: 2018-04-23   Modified: 2024-01-30  

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