Budget Amount *help |
¥44,200,000 (Direct Cost: ¥34,000,000、Indirect Cost: ¥10,200,000)
Fiscal Year 2020: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2019: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2018: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
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Outline of Final Research Achievements |
(1) Establishment of a chemical synthesis method for artificial nucleosomes: We established a new peptide ligation method using organometallic complexes, and synthesized four types of core histones (H2A, H2B, H3, and H4) and linker histone H1. (2) Creation of supernucleosomes: In order to discover the essence of the regulation of cell functions by atoms, we investigated protein modification methods and established a method for the chemical synthesis of "supernucleosomes" with functions not found in nature.
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