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Study for elucidation of the structures and functions of nano-sized membrane domains using glycolipid probes

Research Project

Project/Area Number 18H03942
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 38:Agricultural chemistry and related fields
Research InstitutionGifu University

Principal Investigator

Ando Hiromune  岐阜大学, 糖鎖生命コア研究所, 教授 (20372518)

Co-Investigator(Kenkyū-buntansha) 鈴木 健一  岐阜大学, 糖鎖生命コア研究所, 教授 (50423059)
矢木 宏和  名古屋市立大学, 医薬学総合研究院(薬学), 講師 (70565423)
Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2021: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2019: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2018: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Keywordsガングリオシド / 細胞膜ドメイン / 1分子イメージング / 糖鎖 / 光応答性プローブ / スフィンゴ糖脂質 / 脂質ラフト
Outline of Final Research Achievements

To understand the structure and function of microdomains formed in cell membranes at the molecular level, this study focused on elucidating the membrane dynamics of gangliosides, which are key molecules in the formation of microdomains, through an interdisciplinary study of synthetic chemistry, single molecule imaging, and comprehensive structural analysis.This research established a method for comprehensive analysis of membrane protein receptors with high affinity to gangliosides and provided structural insights into the microdomains formed in the membrane. We have also developed various ganglioside probes for behavior analysis in the cell membrane and found that gangliosides have a propensity to form homodimers specifically and frequently in the steady-state plasma membrane.

Academic Significance and Societal Importance of the Research Achievements

本研究により、これまで不明であった細胞膜におけるガングリオシドの動態が1分子レベルで明らかとなった。さらに、ガングリオシドが細胞膜で特異的に相互作用する膜タンパク質を明らかにする手法を確立し、細胞膜で形成される一過的な分子複合体の構造的な知見を解析することが可能となった。これらの成果は、細胞膜の機能理解を進めるために基盤となる重要な知見を提供するものであり、感染、癌細胞の転移などの細胞表面で生じる現象理解の発展につながると期待できる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (76 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (29 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 27 results,  Open Access: 11 results) Presentation (30 results) (of which Int'l Joint Research: 10 results,  Invited: 18 results) Book (3 results) Remarks (6 results) Funded Workshop (1 results)

  • [Int'l Joint Research] リール大学/CNRS(フランス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] アルバータ大学(カナダ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] オクスフォード大学(英国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ハノーバー医科大学(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] リール大学/CNRS(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] アルバータ大学(カナダ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] オクスフォード大学(英国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking2021

    • Author(s)
      Nakato Mitsuhiro、Shiranaga Naoko、Tomioka Maiko、Watanabe Hitomi、Kurisu Junko、Kengaku Mineko、Komura Naoko、Ando Hiromune、Kimura Yasuhisa、Kioka Noriyuki、Ueda Kazumitsu
    • Journal Title

      Journal of Biological Chemistry

      Volume: 296 Pages: 100166-100166

    • DOI

      10.1074/jbc.ra120.015997

    • NAID

      120007177776

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers2021

    • Author(s)
      Nakano Mikito、Hanashima Shinya、Hara Toshiaki、Kabayama Kazuya、Asahina Yuya、Hojo Hironobu、Komura Naoko、Ando Hiromune、Nyholm Thomas K.M.、Slotte J. Peter、Murata Michio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Biomembranes

      Volume: 1863 Issue: 8 Pages: 183623-183623

    • DOI

      10.1016/j.bbamem.2021.183623

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis of Diverse Seleno‐Glycolipids <i>via</i> the Transacetalization of Selenoacetals2021

    • Author(s)
      Fukuo Hayata、Suzuki Tatsuya、Shimabukuro Junpei、Komura Naoko、Tanaka Hide‐Nori、Imamura Akihiro、Ishida Hideharu、Ando Hiromune
    • Journal Title

      European Journal of Organic Chemistry

      Volume: 2021 Issue: 40 Pages: 5455-5467

    • DOI

      10.1002/ejoc.202100847

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced Chemical Methods for Stereoselective Sialylation and Their Applications in Sialoglycan Syntheses2021

    • Author(s)
      Vibhute Amol M.、Komura Naoko、Tanaka Hide‐Nori、Imamura Akihiro、Ando Hiromune
    • Journal Title

      The Chemical Record

      Volume: 21 Issue: 11 Pages: 3194-3223

    • DOI

      10.1002/tcr.202100080

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematic strategy utilizing 1,5-lactamization for the synthesis of the trisialylated galactose unit of c-series gangliosides2020

    • Author(s)
      Shirasaki Junya、Tanaka Hide-Nori、Konishi Miku、Hirose Yuya、Imamura Akihiro、Ishida Hideharu、Kiso Makoto、Ando Hiromune
    • Journal Title

      Tetrahedron Letters

      Volume: 61 Issue: 16 Pages: 151759-151759

    • DOI

      10.1016/j.tetlet.2020.151759

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient diversification of GM3 gangliosides via late-stage sialylation and dynamic glycan structural studies with 19F solid-state NMR2020

    • Author(s)
      Takahashi Maina、Shirasaki Junya、Komura Naoko、Sasaki Katsuaki、Tanaka Hide-Nori、Imamura Akihiro、Ishida Hideharu、Hanashima Shinya、Murata Michio、Ando Hiromune
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 18 Issue: 15 Pages: 2902-2913

    • DOI

      10.1039/d0ob00437e

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeostatic and pathogenic roles of GM3 ganglioside molecular species in TLR4 signaling in obesity2020

    • Author(s)
      Kanoh Hirotaka、Nitta Takahiro、Go Shinji、Inamori Kei‐ichiro、Veillon Lucas、Nihei Wataru、Fujii Mayu、Kabayama Kazuya、Shimoyama Atsushi、Fukase Koichi、Zonca Asia、Cattaneo Anna、Letizia Marilena、Ciampa Maria、Mauri Laura、Prinetti Alessandro、Sonnino Sandro、Suzuki Akemi、Inokuchi Jin‐ichi et. al.
    • Journal Title

      The EMBO Journal

      Volume: - Issue: 12 Pages: 1-20

    • DOI

      10.15252/embj.2019101732

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Control of Lipid Bilayer Phases of Cell-Sized Liposomes by Surface-Engineered Plasmonic Nanoparticles2020

    • Author(s)
      Tomohiro Nobeyama、Kazuki Shigyou、Hirotaka Nakatsuji、Hiroshi Sugiyama、Naoko Komura、Hiromune Ando、Tsutomu Hamada、Tatsuya Murakami
    • Journal Title

      Langmuir

      Volume: 36 Issue: 26 Pages: 7741-7746

    • DOI

      10.1021/acs.langmuir.0c00049

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indirect synthetic route to α-L-fucosides via highly stereoselective construction of α-L-galactosides followed by C6-deoxygenation2020

    • Author(s)
      Hirotaka Tomida、Takuya Matsuhashi、Hide-Nori Tanaka、Naoko Komura、Hiromune Ando、Akihiro Imamura、Hideharu Ishida
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 18 Issue: 26 Pages: 5017-5033

    • DOI

      10.1039/d0ob01128b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Fluorescent Ganglioside GD3 and GQ1b Analogs for Elucidation of Raft-Associated Interactions2020

    • Author(s)
      M. Konishi, N. Komura, Y. Hirose, Y. Suganuma, H. N. Tanaka, A. Imamura, H. Ishida, K. G. N. Suzuki*, H. Ando*
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 85 Issue: 24 Pages: 15998-16013

    • DOI

      10.1021/acs.joc.0c01493

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Synthesis of Diglycosyl Diacylglycerols with Glycosyl Donors Bearing a β-Stereodirecting 2,3-Naphthalenedimethyl Protecting Group2020

    • Author(s)
      Yagami Nahoko、Vibhute Amol M.、Tanaka Hide-Nori、Komura Naoko、Imamura Akihiro、Ishida Hideharu、Ando Hiromune
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 85 Issue: 24 Pages: 16166-16181

    • DOI

      10.1021/acs.joc.0c02121

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Challenges in the Chemical Complexity and Biological Functionality of Gangliosides2019

    • Author(s)
      Ando Hiromune
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 31 Issue: 181 Pages: SE48-SE49

    • DOI

      10.4052/tigg.1923.2SE

    • NAID

      130007683616

    • ISSN
      0915-7352, 1883-2113
    • Year and Date
      2019-07-25
    • Related Report
      2019 Annual Research Report
  • [Journal Article] Challenges in the Chemical Complexity and Biological Functionality of Gangliosides2019

    • Author(s)
      安藤 弘宗
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 31 Issue: 181 Pages: SJ48-SJ49

    • DOI

      10.4052/tigg.1923.2SJ

    • NAID

      130007683618

    • ISSN
      0915-7352, 1883-2113
    • Year and Date
      2019-07-25
    • Related Report
      2019 Annual Research Report
  • [Journal Article] On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q.2019

    • Author(s)
      Saeko Yanaka,Rina Yogo,Hiroki Watanabe,Yuki Taniguchi,Tadashi Satoh,Naoko Komura,Hiromune Ando,Hirokazu Yagi,Nobuhiro Yuki,Takayuki Uchihashi,Koichi Kato
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 1 Pages: 147-147

    • DOI

      10.3390/ijms21010147

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Defining raft domains in the plasma membrane2019

    • Author(s)
      Akihiro Kusumi、Takahiro K. Fujiwara、Taka A. Tsunoyama、Rinshi S. Kasai、An‐An Liu、Koichiro M. Hirosawa、Masanao Kinoshita、Nobuaki Matsumori、Naoko Komura、Hiromune Ando、Kenichi G. N. Suzuki
    • Journal Title

      Traffic

      Volume: 21 Issue: 1 Pages: 106-137

    • DOI

      10.1111/tra.12718

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of fluorescently labeled SSEA-3, SSEA-4 and Globo-H glycosphingolipids for elucidating molecular interactions in the cell membrane.2019

    • Author(s)
      Sachi Asano, Rita Pal, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Kenichi G.N. Suzuki*, Hiromune Ando*(*corresponding author).
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 24 Pages: 6187-6187

    • DOI

      10.3390/ijms20246187

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] p-tert-Butyl Groups Improve the Utility of Aromatic Protecting Groups in Carbohydrate Synthesis2019

    • Author(s)
      Asano Sachi、Tanaka Hide-Nori、Imamura Akihiro、Ishida Hideharu、Ando Hiromune
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 11 Pages: 4197-4200

    • DOI

      10.1021/acs.orglett.9b01372

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sialyl LewisX mimic-decorated liposomes for anti-angiogenic everolimus delivery to E-selectin expressing endothelial cells2019

    • Author(s)
      Chantarasrivong Chanikarn、Higuchi Yuriko、Tsuda Masahiro、Yamane Yuuki、Hashida Mitsuru、Konishi Miku、Komura Naoko、Ando Hiromune、Yamashita Fumiyoshi
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 36 Pages: 20518-20527

    • DOI

      10.1039/c9ra01943j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Total Synthesis of Sialyl Inositol Phosphosphingolipids CJP-2, CJP-3, and CJP-4 Isolated from Feather Star Comanthus japonica2019

    • Author(s)
      Goto Kenta、Tamai Hideki、Takeda Yoh、Tanaka Hide-Nori、Mizuno Takashi、Imamura Akihiro、Ishida Hideharu、Kiso Makoto、Ando Hiromune
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 11 Pages: 4054-4057

    • DOI

      10.1021/acs.orglett.9b01229

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of ganglioside analogs containing fluorescently labeled GalNAc for single-molecule imaging2019

    • Author(s)
      Machi Koikeda、Naoko Komura、Hide-Nori Tanaka、Akihiro Imamura、Hideharu Ishida、Makoto Kiso、Hiromune Ando
    • Journal Title

      Journal of Carbohydrate Chemistry

      Volume: 38 Issue: 7-8 Pages: 509-527

    • DOI

      10.1080/07328303.2019.1609019

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Constrained sialic acid donors enable selective synthesis of α-glycosides2019

    • Author(s)
      Komura Naoko、Kato Keiichi、Udagawa Taro、Asano Sachi、Tanaka Hide-Nori、Imamura Akihiro、Ishida Hideharu、Kiso Makoto、Ando Hiromune
    • Journal Title

      Science

      Volume: 364 Issue: 6441 Pages: 677-680

    • DOI

      10.1126/science.aaw4866

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of a 1,2-cis-indoxyl galactoside as a chromogenic glycosidase substrate2019

    • Author(s)
      Sakuto Nagata, Hirotaka Tomida, Haruka Iwai-Hirose, Hide-Nori Tanaka, Hiromune Ando, Akihiro Imamura, Hideharu Ishida
    • Journal Title

      RSC Advances

      Volume: 9 Issue: 48 Pages: 28241-28247

    • DOI

      10.1039/c9ra05797h

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and Glycan?Protein Interaction Studies of Se-Sialosides by 77Se NMR2019

    • Author(s)
      Suzuki Tatsuya、Hayashi Chieka、Komura Naoko、Tamai Rie、Uzawa Jun、Ogawa Junya、Tanaka Hide-Nori、Imamura Akihiro、Ishida Hideharu、Kiso Makoto、Yamaguchi Yoshiki、Ando Hiromune
    • Journal Title

      Organic Letters

      Volume: 21 Issue: 16 Pages: 6393-6396

    • DOI

      10.1021/acs.orglett.9b02303

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical synthesis of diglucosyl diacylglycerols utilizing glycosyl donors with stereodirecting cyclic silyl protective groups2019

    • Author(s)
      Takato Koichi、Kurita Motoki、Yagami Nahoko、Tanaka Hide-Nori、Ando Hiromune、Imamura Akihiro、Ishida Hideharu
    • Journal Title

      Carbohydrate Research

      Volume: 483 Pages: 107748-107748

    • DOI

      10.1016/j.carres.2019.107748

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Revealing the raft domain organization in the plasma membrane by single-molecule imaging of fluorescent ganglioside analogs.2018

    • Author(s)
      Kenichi G. N. Suzuki, Hiromune Ando, Naoko Komura, Akihiro Imamura, Hideharu Ishida, Makoto Kiso, Takahiro K. Fujiwara, Akihiro Kusumi.
    • Journal Title

      Methods in Enzymology

      Volume: 598 Pages: 267-282

    • DOI

      10.1016/bs.mie.2017.06.038

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise α2,6 sialic acid-dependent and -independent interactions.2018

    • Author(s)
      Alborzian Deh Sheikh A, Akatsu C, Imamura A, Abdu-Allah HHM, Takematsu H, Ando H, Ishida H, Tsubata T
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 495 Issue: 1 Pages: 854-859

    • DOI

      10.1016/j.bbrc.2017.11.086

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CD22-binding synthetic sialosides regulate B lymphocyte proliferation through CD22 ligand-dependent and independent pathways, and enhances antibody production in mice2018

    • Author(s)
      2.Matsubara N, Imamura A, Yonemiz Tu, Akatsu C, Yang H, Ueki A, Watanabe N, Abdu-Allah H, Numoto N, Takematsu H, Kitazume S, Tedder FT, Marth JD, Ito N, Ando H, Ishida H, Kiso M, and Tsubata T
    • Journal Title

      Frontiers in Immunology

      Volume: - Pages: 820-820

    • DOI

      10.3389/fimmu.2018.00820

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis of the Core Oligosaccharides of Lipooligosaccharides from Campylobacter jejuni : A Putative Cause of Guillain?Barr? Syndrome2018

    • Author(s)
      Yoshida Fumi、Yoshinaka Hiroki、Tanaka Hidenori、Hanashima Shinya、Yamaguchi Yoshiki、Ishihara Mikio、Saburomaru Miyuki、Kato Yuki、Saito Risa、Ando Hiromune、Kiso Makoto、Imamura Akihiro、Ishida Hideharu
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 3 Pages: 796-805

    • DOI

      10.1002/chem.201804862

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] J(77Se,1H) and J(77Se,13C) couplings of seleno-carbohydrates obtained by 77Se satellite 1D 13C spectroscopy and 77Se selective HR-HMBC spectroscopy2018

    • Author(s)
      Uzawa Jun、Shimabukuro Junpei、Suzuki Tatsuya、Imamura Akihiro、Ishida Hideharu、Ando Hiromune、Yamaguchi Yoshiki
    • Journal Title

      Magnetic Resonance in Chemistry

      Volume: 56 Issue: 9 Pages: 836-846

    • DOI

      10.1002/mrc.4746

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 糖脂質のシアリル化反応を利用した ラクト系ガングリオシドプローブの創製2022

    • Author(s)
      髙橋 舞菜、河村 奈緒子、田中 秀則、今村 彰宏、石田 秀治、 安藤 弘宗
    • Organizer
      糖鎖科学中部拠点第17回「若手の力」フォーラム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 二環性シアル酸を応用したα ( 2,9)ポリシアル酸の合成研究2022

    • Author(s)
      加藤雅大、河村奈緒子、白崎淳哉、田中秀則、今村彰宏、石田秀治、安藤弘宗
    • Organizer
      糖鎖科学中部拠点第17回「若手の力」フォーラム
    • Related Report
      2021 Annual Research Report
  • [Presentation] GalNAc 側鎖を有する哺乳動物 GPI の全合成研究2022

    • Author(s)
      平塚 諒大、田中 秀則、浜島 将伍、河村 奈緒子、今村 彰宏、石田 秀治、安藤 弘宗
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 架橋部ハロゲン置換が二環性シアル酸供与体の反応性にもたらす効果の検証2022

    • Author(s)
      安武 作真、河村 奈緒子、宇田川 太郎、田中 秀則、今村 彰宏、石田 秀治、安藤 弘 宗
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 完全なα選択性を示す Kdo グリコシド化法の開発とその利用2022

    • Author(s)
      濵島 将伍、野口晴佳、河村奈緒子、田中秀則、今村彰宏、石田秀治、一柳剛、安藤弘宗
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規合成法を用いたラクト系スフィンゴ糖脂質プローブの創製と挙動解析2022

    • Author(s)
      髙橋 舞菜、河村 奈緒子、鈴木健一、田中 秀則、今村 彰宏、石田 秀治、 安藤 弘宗
    • Organizer
      日本農芸化学会2022年度大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 糖鎖科学と木質科学の接点-多様な分子の力の探究-2022

    • Author(s)
      安藤弘宗
    • Organizer
      第72回日本木材学会大会 公開シンポジウム「地域社会から世界に発信する木質バイオサイエンスへの挑戦」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 生物機能の理解、開拓、応用の基盤となるシアル酸含有糖鎖の創製2022

    • Author(s)
      安藤弘宗
    • Organizer
      日本薬学会第142年会 一般シンポジウムS17 薬学領域に貢献するメディシナルケミストリー最前線
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Stereoselective synthesis of sialo-glycans for accelerating glycobiology2021

    • Author(s)
      Hiromune Ando
    • Organizer
      ACS Carbohydrate Division Young Investigator Symposium
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical Synthesis of Gangliosides to Explore the Cell Membrane Domains2021

    • Author(s)
      Hiromune Ando
    • Organizer
      3rd Australasian Glycoscience Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Fully a-selective sialidation and its application to glycoconjugate synthesis2021

    • Author(s)
      Hiromune Ando
    • Organizer
      Pacifichem 2021, Advances in Glycan Engineering and Glycans from the Microbial World
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 二環性シアル酸を利用したα α(2,9)ポリシアル酸の合成研究2021

    • Author(s)
      加藤雅大、白崎淳哉、河村奈緒子、田中秀則、今村彰宏、石田秀治、安藤弘宗
    • Organizer
      第40回日本糖質学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 合成終盤での糖脂質のシアリル化によるラクト系ガングリオシドプローブの合成2021

    • Author(s)
      髙橋 舞菜、河村 奈緒子、田中 秀則、今村 彰宏、石田 秀治、 安藤 弘宗
    • Organizer
      第40回日本糖質学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 完全な立体選択性を示す Kdo α-グリコシド化法の開発研究2021

    • Author(s)
      濵島 将伍、野口晴佳、河村奈緒子、田中秀則、今村彰宏、石田秀治、一柳剛、安藤弘宗
    • Organizer
      第40回日本糖質学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規光反応性基「セレノフェン-2-イル置換型α-ケトアミド」を用いた光親和性スフィンゴ糖脂質プ ローブの開発と細胞膜ラフト親和性相互作用の理解に向けた応用2021

    • Author(s)
      浅野 早知、田中 秀則、今村 彰宏、石田 秀治、矢木 宏和、加藤 晃一、水上 大 輝 、平井 剛 、安藤 弘宗
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脂質ラフトの1分子イメージングに向けたラクト系ガングリオシドプローブの合成2021

    • Author(s)
      高橋 舞菜、白崎 淳哉、河村 奈緒子、田中 秀則、今村 彰宏、石田 秀治、安藤 弘 宗
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 二環性シアル酸を用いたα(2,9)ポリシアル酸の合成研究2021

    • Author(s)
      加藤 雅大、白崎 淳哉、河村 奈緒子、田中 秀則、今村 彰宏、石田 秀治、安藤 弘宗
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A fully stereoselective method for a-sialylation2020

    • Author(s)
      Hiromune Ando
    • Organizer
      Two day International E-Seminar Chemistry, Biology and COVID-19
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical synthesis of sialic acid-containing glycans2020

    • Author(s)
      Hiromune Ando
    • Organizer
      Indian Carbohydrates E-Meetings (ICarE)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 合成化学で糖鎖の未知を拓く2020

    • Author(s)
      安藤弘宗
    • Organizer
      第5回ケムステVシンポジウム 「最先端ケムバイオ」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] A simple and powerful solution of stereoselective sialylation2019

    • Author(s)
      Ando Hiromune
    • Organizer
      CarboXXXIV International Conference on “Emerging Frontiers in Carbojhydrate Chemistry and Glycobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rewritting the synthesis strategy toward sialic acid-containing glycans2019

    • Author(s)
      Ando Hiromune
    • Organizer
      ACS Fall 2019 National Meeting, Japanese-American Symposium on Applied & Translational Glycosciences
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Stereoselective α-glycosidation using bicyclic sialic acid donors2019

    • Author(s)
      Ando Hiromue
    • Organizer
      Gordon Research Conference: Carbohydrates
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖鎖合成の難題に挑む“あっさり、どっさり出来る” を求めて2019

    • Author(s)
      安藤 弘宗
    • Organizer
      第17回糖鎖科学コンソーシアムシンポジウム「グライコサイエンス&エンジニアリングの未来」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 50年来の糖化学の難問を解く2019

    • Author(s)
      安藤 弘宗
    • Organizer
      有機合成化学協会中国四国支部第80回パネル討論会「糖鎖合成の未踏領域に挑む」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 糖鎖合成の難関に挑む2019

    • Author(s)
      安藤 弘宗
    • Organizer
      第68回応用糖質科学学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Chemistry and chemical biology of sialic acid2018

    • Author(s)
      Ando, H.
    • Organizer
      SIALOGLYCO2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] あまーい糖合成から学ぶ生命維持活動の神秘2018

    • Author(s)
      安藤弘宗
    • Organizer
      第8回CSJ化学フェスタ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 精密合成で拓く糖鎖の異分野融合研究2018

    • Author(s)
      安藤弘宗
    • Organizer
      第49回中部化学関係学協会支部連合秋季大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Diverse chemical synthesis of sialic acid-containing glycans2018

    • Author(s)
      Ando, H
    • Organizer
      Sweer'18 Glycochemistry, Biology and Technology (SGBT 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] バイオインダストリー2021

    • Author(s)
      安藤弘宗
    • Total Pages
      90
    • Publisher
      シーエムシー出版
    • Related Report
      2021 Annual Research Report
  • [Book] シーエムシー出版2019

    • Author(s)
      河村 奈緒子、安藤 弘宗
    • Total Pages
      8
    • Publisher
      ファインケミカル
    • Related Report
      2019 Annual Research Report
  • [Book] Advances in Experimental Medicine and Biology2018

    • Author(s)
      Suzuki, K.G.N., Ando, H., Komura, N., Fujiwara, T., Kiso, M., Kusumi, A.
    • Total Pages
      277
    • Publisher
      Springer Nature
    • ISBN
      9789811321580
    • Related Report
      2018 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      https://www1.gifu-u.ac.jp/~kassei1/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 所属研究機関ホームページ

    • URL

      https://igcore.thers.ac.jp/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      https://www1.gifu-u.ac.jp/~kassei1/index.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] 所属研究機関ホームページ

    • URL

      https://www1.gifu-u.ac.jp/~igcore/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 岐阜大学応用生物科学部生理活性物質学研究室ホームページ

    • URL

      https://www1.gifu-u.ac.jp/~kassei1/

    • Related Report
      2019 Annual Research Report
  • [Remarks] https://www1.gifu-u.ac.jp/~kassei1/

    • Related Report
      2018 Annual Research Report
  • [Funded Workshop] International Symposium on Bio-CHAINs from Single Molecules to Highly Organized Systems2019

    • Related Report
      2019 Annual Research Report

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Published: 2018-04-23   Modified: 2023-01-30  

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