| Budget Amount *help |
¥44,980,000 (Direct Cost: ¥34,600,000、Indirect Cost: ¥10,380,000)
Fiscal Year 2021: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2019: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2018: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
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| Outline of Final Research Achievements |
To understand the structure and function of microdomains formed in cell membranes at the molecular level, this study focused on elucidating the membrane dynamics of gangliosides, which are key molecules in the formation of microdomains, through an interdisciplinary study of synthetic chemistry, single molecule imaging, and comprehensive structural analysis.This research established a method for comprehensive analysis of membrane protein receptors with high affinity to gangliosides and provided structural insights into the microdomains formed in the membrane. We have also developed various ganglioside probes for behavior analysis in the cell membrane and found that gangliosides have a propensity to form homodimers specifically and frequently in the steady-state plasma membrane.
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