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Chemical biology research solves the 3W1H of tenuazonic acid

Research Project

Project/Area Number 18H03945
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 38:Agricultural chemistry and related fields
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Osada Hiroyuki  国立研究開発法人理化学研究所, 環境資源科学研究センター, グループディレクター (80160836)

Co-Investigator(Kenkyū-buntansha) 永野 真吾  鳥取大学, 工学研究科, 教授 (60286440)
本山 高幸  国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (70291094)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2020: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2019: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2018: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Keywords植物病原菌 / 共生 / 生物間相互作用 / 二次代謝産物 / かび毒 / 植物病害防除 / X線結晶構造解析 / 生合成メカニズム / マイコトキシン
Outline of Final Research Achievements

"3W1H" of tenuazonic acid was analyzed. Regarding how to make tenuazonic acid, we performed X-ray crystal structure analysis of the TAS1 KS domain that catalyzes the Dieckmann cyclization reaction, which is the key to biosynthesis, and the reaction mechanism was clarified. Regarding when to make tenuazonic acid, we found that the compound that induces the production of tenuazonic acid acts via LAE1. This compound also activated secondary metabolism in other filamentous fungus. Regarding the reason for making tenuazonic acid, we obtained data suggesting that it has a function in the late stage of infection in rice blast fungus. On the other hand, it was found that the compound produced by a Group D TAS1 homologue had proteasome inhibitory activity.

Academic Significance and Societal Importance of the Research Achievements

微生物の生産する多種多様な二次代謝産物は重要な創薬基盤となってきた。ところが、微生物の二次代謝産物の環境中での本来の生理的役割(Why?)はほとんど不明である。また、その生合成(How?)や生産制御(When? Where?)についても同様で不明な点が多い。本申請では、我々が見出したユニークな酵素で生合成される糸状菌代謝産物テヌアゾン酸をモデルに、抗生物質学の最大の謎のひとつである二次代謝産物の“3W1H”の解明に挑み、基盤となるデータを得ることができた。今後、創薬などへの応用が期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Annual Research Report
  • 2018 Annual Research Report
  • Research Products

    (84 results)

All 2021 2020 2019 2018

All Journal Article (24 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 24 results,  Open Access: 9 results) Presentation (56 results) (of which Int'l Joint Research: 16 results,  Invited: 15 results) Book (2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H6472021

    • Author(s)
      Lopez Julius Adam V.、Nogawa Toshihiko、Futamura Yushi、Aono Harumi、Hashizume Daisuke、Osada Hiroyuki
    • Journal Title

      The Journal of Antibiotics

      Volume: ahead of online Issue: 7 Pages: 477-479

    • DOI

      10.1038/s41429-021-00420-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus2021

    • Author(s)
      Furuyama Yuuki、Motoyama Takayuki、Nogawa Toshihiko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 5 Pages: 1290-1293

    • DOI

      10.1093/bbb/zbab021

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator.2021

    • Author(s)
      Takao R, Sakai K, Koshino H, Osada H, Takahashi S.
    • Journal Title

      Biosci Biotechnol Biochem

      Volume: 85 Issue: 3 Pages: 714-721

    • DOI

      10.1093/bbb/zbaa082

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase2021

    • Author(s)
      Furuyama Yuuki、Motoyama Takayuki、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Kiyota Hiromasa、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 1 Pages: 126-133

    • DOI

      10.1093/bbb/zbaa035

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening2021

    • Author(s)
      Rawa Mira Syahfriena Amir、Nogawa Toshihiko、Okano Akiko、Futamura Yushi、Nakamura Takemichi、Wahab Habibah A、Osada Hiroyuki
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 1 Pages: 69-76

    • DOI

      10.1093/bbb/zbaa051

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Heterologous Expression of the Biosynthetic Gene Cluster for Verticilactam and Identification of Analogues2020

    • Author(s)
      Nogawa Toshihiko、Terai Atsutaka、Amagai Keita、Hashimoto Junko、Futamura Yushi、Okano Akiko、Fujie Manabu、Satoh Noriyuki、Ikeda Haruo、Shin-ya Kazuo、Osada Hiroyuki、Takahashi Shunji
    • Journal Title

      Journal of Natural Products

      Volume: 83 Issue: 12 Pages: 3598-3605

    • DOI

      10.1021/acs.jnatprod.0c00755

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uncovering hidden sesquiterpene biosynthetic pathway through expression boost area-mediated productivity enhancement in basidiomycete2020

    • Author(s)
      Asai Shihori、Tsunematsu Yuta、Masuya Takahiro、Otaka Junnosuke、Osada Hiroyuki、Watanabe Kenji
    • Journal Title

      The Journal of Antibiotics

      Volume: 73 Issue: 10 Pages: 721-728

    • DOI

      10.1038/s41429-020-0355-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique features of the ketosynthase domain in a nonribosomal peptide synthetase?polyketide synthase hybrid enzyme, tenuazonic acid synthetase 12020

    • Author(s)
      Yun Choong-Soo、Nishimoto Kazuki、Motoyama Takayuki、Shimizu Takeshi、Hino Tomoya、Dohmae Naoshi、Nagano Shingo、Osada Hiroyuki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 33 Pages: 11602-11612

    • DOI

      10.1074/jbc.ra120.013105

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.2020

    • Author(s)
      Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 10230-10230

    • DOI

      10.1038/s41598-020-66974-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Productivity and bioactivity of enokipodins A-D of Flammulina rossica and Flammulina velutipes2020

    • Author(s)
      Tabuchi Akiko、Fukushima-Sakuno Emi、Osaki-Oka Kumiko、Futamura Yushi、Motoyama Takayuki、Osada Hiroyuki、Ishikawa Noemia Kazue、Nagasawa Eiji、Tokimoto Keisuke
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 5 Pages: 876-886

    • DOI

      10.1080/09168451.2020.1714421

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-942020

    • Author(s)
      Kato Sho、Motoyama Takayuki、Futamura Yushi、Uramoto Masakazu、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Tanaka Akira、Takahashi-Ando Naoko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 6 Pages: 1303-1307

    • DOI

      10.1080/09168451.2020.1725419

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene2020

    • Author(s)
      Kato Sho、Motoyama Takayuki、Uramoto Masakazu、Nogawa Toshihiko、Kamakura Takashi、Osada Hiroyuki
    • Journal Title

      The Journal of Antibiotics

      Volume: - Issue: 7 Pages: 475-479

    • DOI

      10.1038/s41429-020-0295-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists2019

    • Author(s)
      Mikame Yu、Yoshida Kazuko、Hashizume Daisuke、Hirai Go、Nagasawa Kazuo、Osada Hiroyuki、Sodeoka Mikiko
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 14 Pages: 3496-3500

    • DOI

      10.1002/chem.201806056

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.2019

    • Author(s)
      Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N
    • Journal Title

      J Biol Chem

      Volume: 294 Issue: 9 Pages: 2988-2996

    • DOI

      10.1074/jbc.ra118.004741

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593.2019

    • Author(s)
      Panthee S., Takahashi S.*, Hayashi T., Shimizu T, and Osada H.
    • Journal Title

      Sci. Rep.

      Volume: 9 Issue: 1 Pages: 5802-5802

    • DOI

      10.1038/s41598-019-42268-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abscisic Acid Derivatives with Different Alkyl Chain Lengths Activate Distinct Abscisic Acid Receptor Subfamilies2019

    • Author(s)
      Yoshida Kazuko、Kondoh Yasumitsu、Iwahashi Fukumatsu、Nakano Takeshi、Honda Kaori、Nagano Eiki、Osada Hiroyuki
    • Journal Title

      ACS Chemical Biology

      Volume: 14 Issue: 9 Pages: 1964-1971

    • DOI

      10.1021/acschembio.9b00453

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and biological activity of metarhizin C, a new stereoisomer of BR-050 from a fungus Tolypocladium album RK17-F00072019

    • Author(s)
      Nogawa T., Kawatani M., Okano A., Futamura Y., Aono H., Shimizu T., Kato N., Kikuchi H., and Osada H.
    • Journal Title

      J. Antibiot.

      Volume: 72 Issue: 12 Pages: 996-1000

    • DOI

      10.1038/s41429-019-0229-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647.2019

    • Author(s)
      Lopez JAV, Nogawa T, Futamura Y, Shimizu T, Osada H.
    • Journal Title

      J Antibiot

      Volume: 72 Issue: 12 Pages: 991-995

    • DOI

      10.1038/s41429-019-0217-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001.2019

    • Author(s)
      Yamamoto K, Futamura Y, Uson-Lopez RA, Aono H, Shimizu T, Osada H.
    • Journal Title

      J Antibiot

      Volume: 72 Issue: 12 Pages: 986-990

    • DOI

      10.1038/s41429-019-0239-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.2019

    • Author(s)
      Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.
    • Journal Title

      Biochim Biophys Acta Proteins Proteom.

      Volume: 1867 Issue: 1 Pages: 28-37

    • DOI

      10.1016/j.bbapap.2018.06.001

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of Nectriapyrone Biosynthesis in the Rice Blast Fungus Pyricularia oryzae by Disturbance of the Two-Component Signal Transduction System2019

    • Author(s)
      Motoyama Takayuki、Nogawa Toshihiko、Hayashi Toshiaki、Hirota Hiroshi、Osada Hiroyuki
    • Journal Title

      ChemBioChem

      Volume: 20 Issue: 5 Pages: 693-700

    • DOI

      10.1002/cbic.201800620

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.2019

    • Author(s)
      Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.
    • Journal Title

      FEBS Lett.

      Volume: 593 Issue: 8 Pages: 763-776

    • DOI

      10.1002/1873-3468.13361

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Structures and synthesis of hitoyopodins: bioactive aromatic sesquiterpenoids produced by the mushroom Coprinopsis cinerea.2018

    • Author(s)
      Otaka J, Shimizu T, Futamura Y, Hashizume D, Osada H.
    • Journal Title

      Org Lett

      Volume: 20 Issue: 19 Pages: 6294-6297

    • DOI

      10.1021/acs.orglett.8b02788

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum2018

    • Author(s)
      Maeda Kazuyuki、Ichikawa Hinayo、Nakajima Yuichi、Motoyama Takayuki、Ohsato Shuichi、Kanamaru Kyoko、Kobayashi Tetsuo、Nishiuchi Takumi、Osada Hiroyuki、Kimura Makoto
    • Journal Title

      ACS Chemical Biology

      Volume: 13 Issue: 5 Pages: 1260-1269

    • DOI

      10.1021/acschembio.8b00044

    • NAID

      120006523680

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] 天然物創薬に適した表現型スクリーニング2021

    • Author(s)
      長田 裕之
    • Organizer
      日本農芸化学会東北支部 第155回大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Chemical induction of fungal secondary metabolism toward production of novel bioactive secondary metabolites2021

    • Author(s)
      Abdelhakim Amin Islam Adel、本山 高幸、二村 友史、長田 裕之
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A new peptaibol from the fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening2021

    • Author(s)
      Mira Syahfriena Amir Rawa, Toshihiko Nogawa, Akiko Okano, Yushi Futamura, Takemichi Nakamura, Habibah A. Wahab, Hiroyuki Osada
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A new cytokinin-type compound and cytotoxic tryptamine derivatives from Streptomyces sp. 80H6472021

    • Author(s)
      Julius Lopez, Toshihiko Nogawa, Yushi Futamura, Harumi Aono, Kazuko Yoshida, Daisuke Hashizume, Hiroyuki Osada
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] カリン合成酵素 Phm7 および Fsa2 の in vitro アッセイ系の構築2021

    • Author(s)
      加藤 直樹 、藤山 敬介 、野川 俊彦 、長田 裕之 、永野 真吾 、高橋 俊二
    • Organizer
      日本農芸化学会2021年度大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Verticilactam生合成遺伝子クラスター異種発現による新規類縁体の単離と構造決定2020

    • Author(s)
      野川 俊彦、寺井 淳高、天貝 啓太、橋本 絢子、藤江 学、佐藤 矩行、池田 治生、新家 一男、長田 裕之、 高橋 俊二
    • Organizer
      第62回天然有機化合物討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] イネいもち病菌におけるpyriculol類縁体の未知生理機能の解析2020

    • Author(s)
      古山 祐貴 、本山 高幸 、鎌倉 高志、長田裕之
    • Organizer
      糸状菌分子生物学研究会若手の会 第八回ワークショップ
    • Related Report
      2020 Annual Research Report
  • [Presentation] タンパク質合成阻害剤hygromycin B処理による二次代謝の誘導と1233A生合成遺伝子クラスターの発見2020

    • Author(s)
      加藤 翔、本山 高幸、浦本 雅一、野川 俊彦、鎌倉 高志、長田 裕之
    • Organizer
      糸状菌分子生物学研究会若手の会 第八回ワークショップ
    • Related Report
      2020 Annual Research Report
  • [Presentation] 一次代謝関連遺伝子の導入によるリベロマイシン生産改善2020

    • Author(s)
      高木 海、白井 智量、岡村 英治、近藤 昭彦、長田 裕之、高橋 俊二
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 放線菌由来抗生物質により生産誘導されるイネいもち病菌二次代謝産物の生理機能解析2020

    • Author(s)
      古山 祐貴、本山 高幸、野川 俊彦、鎌倉 高志、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ハイグロマイシンBにより生産誘導される二次代謝産物の生合成遺伝子クラスター同定及び生理活性の解析2020

    • Author(s)
      加藤 翔、本山 高幸、二村 友史、浦本 昌和、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 新しいタイプの二次代謝酵素TAS1のホモログを活用した新規生理活性天然化合物の発掘2020

    • Author(s)
      本山 高幸、野川 俊彦、清水 猛、川谷 誠、二村 友史、尹 忠銖、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 放線菌異種発現によるverticilactam新規類縁体の生産と単離・構造決定2020

    • Author(s)
      野川 俊彦、寺井 淳高、新家 一男、池田 治生、高橋 俊二、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] イネいもち病菌の感染防除に関するケミカルバイオロジー研究2020

    • Author(s)
      本山 高幸、二村 友史、長田 裕之
    • Organizer
      日本農芸化学会2020年度大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Selective activation of abscisic acid receptors by 3'-alkyl ABAs2019

    • Author(s)
      Kazuko Yoshida, Yasumitsu Kondoh, Iwahashi Fukumatsu, Takeshi Nakano, Kaori Honda, Eiki Nagano, Hiroyuki Osada
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology 7th Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Chemical synthesis or biosynthesis, that is the question2019

    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Naoki Kato
    • Organizer
      RIKEN-Max Planck Joint Research Center for System Chemical Biology 7th Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification of the pyrrolizilactone biosynthetic gene cluster in Pleosporales sp. RKB35642019

    • Author(s)
      Naoki Kato, Sayaka Hirosawa, Toshihiko Nogawa, Kiyomi Kinugasa, Hiroyuki Osada, Shunji Takahashi
    • Organizer
      The Joint Symposium of 10th Korea-Japan Chemical Biology Symposium and 30th Meeting for New Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Screening of new antifungal compounds based on morphological change of fungi2019

    • Author(s)
      Hiroyuki Osada
    • Organizer
      The 2nd International Symposium on Natural Resources-based Drug Development
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biosynthesis of tenuazonic acid in Pyricularia oryzae2019

    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Cold Spring Harbor Asia conference on Chemical Biology and Drug Discovery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Morphology-based screening of antitumor and antifungal compounds2019

    • Author(s)
      Hiroyuki Osada
    • Organizer
      8th Annual Conference ICBS-2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 深層学習による形態識別を利用した抗真菌物質の探索2019

    • Author(s)
      二村 友史、ウソン- ロペス レイチェル A.、山本 甲斐、室井 誠、長田 裕之
    • Organizer
      日本ケミカルバイオロジー学会 第14回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 微生物由来デカリン含有化合物のケミカルバイオロジー2019

    • Author(s)
      長田 裕之
    • Organizer
      理研シンポジウム: デカリン化合物の化学合成と生合成
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] イネいもち病菌における二次代謝活性化2019

    • Author(s)
      本山高幸、野川俊彦、石井友彬、尹忠銖、長田 裕之
    • Organizer
      第61回天然有機化合物討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リベロマイシン生合成に関わるサクシニル転移酵素の機能解析2019

    • Author(s)
      鬼頭 奈央子、佐藤 裕美、奥村 英夫、熊坂 崇、長田 裕之、高橋 俊二
    • Organizer
      第34回日本放線菌学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] イネいもち病菌における二次代謝活性化2019

    • Author(s)
      本山 高幸、野川 俊彦、尹 忠銖、長田 裕之
    • Organizer
      第10回発酵学フォーラム
    • Related Report
      2019 Annual Research Report
  • [Presentation] 盛岡とケミカルバイオロジー2019

    • Author(s)
      長田 裕之
    • Organizer
      ケミカルバイオロジー特別講演会 in 盛岡
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] タンパク質合成阻害剤により生産誘導されるイネいもち病菌二次代謝産物の生理機能解析2019

    • Author(s)
      古山 祐貴、本山 高幸、鎌倉 高志、長田 裕之
    • Organizer
      19回糸状菌分子生物学研究会コンファレンス
    • Related Report
      2019 Annual Research Report
  • [Presentation] ケトシンターゼドメインによるかび毒テヌアゾン酸の環状骨格形成メカニズム2019

    • Author(s)
      尹 忠銖、西本 一希、 本山 高幸、日野 智也、永野 真吾、長田 裕之
    • Organizer
      19回糸状菌分子生物学研究会コンファレンス
    • Related Report
      2019 Annual Research Report
  • [Presentation] イネいもち病菌におけるnectriapyrone類の生産誘導と生理機能解析2019

    • Author(s)
      本山 高幸、野川 俊彦、長田 裕之
    • Organizer
      19回糸状菌分子生物学研究会コンファレンス
    • Related Report
      2019 Annual Research Report
  • [Presentation] 受容体特異的な 3′-alkyl ABA を用いたアブシジン酸受容体機能解析2019

    • Author(s)
      由田 和津子、近藤 恭光、岩橋 福松、中野 雄司、本田 香織、永野 栄喜、長田 裕之
    • Organizer
      植物化学調節学会 第54回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Novel secondary metabolites isolated from the mushroom Coprinopsis cinerea2019

    • Author(s)
      Junnosuke Otaka, Hiroyuki Osada
    • Organizer
      The 1st International Symposium on Chemical Communication (ISCC2019)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ring formation in biosynthesis of specialized microbial metabolites2019

    • Author(s)
      Hiroyuki Osada
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional analysis of Fsa2-family decalin synthase responsible for stereoselective [4+2] cycloaddition2019

    • Author(s)
      Naoki Kato, Toshihiko Nogawa, Ryo Takita, Kiyomi Kinugasa, Hiroyuki Osada, Shunji Takahashi
    • Organizer
      2nd China-Japan Joint Symposium on Natural Product Biosynthesis
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A microbial broth library and new compounds from microbes2019

    • Author(s)
      Toshihiko Nogawa, Hiroyuki Osada
    • Organizer
      URICAS Symposium 2019
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アカデミア創薬の難しさ2019

    • Author(s)
      長田 裕之
    • Organizer
      第14回 日本がん分子標的治療学会 TRワークショップ
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Development of morphology-based screening system of Pyricularia oryzae using AI2019

    • Author(s)
      二村 友史, Rachael Uson-Lopez、山本 甲斐、室井 誠、長田 裕之
    • Organizer
      The 5th CSRS-ITbM Joint Workshop
    • Related Report
      2018 Annual Research Report
  • [Presentation] 複雑な酸化経路を含むキノコ由来 lagopodin 類の生合成研究2019

    • Author(s)
      桝谷貴洋、平山裕一郎、高西潤、恒松雄太、佐藤道大、大高潤之介、本山高幸、長田裕之、渡辺賢二
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 冬虫夏草(Cordyceps militaris)由来レクチンの機能解析2019

    • Author(s)
      小野晶子 、柏毅、本山高幸、崔宰熏、平井浩文、道羅英夫、長田裕之、河岸洋和、鈴木智大
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] タンパク質合成阻害剤による糸状菌への二次代謝産物生産の誘導2019

    • Author(s)
      加藤翔、本山高幸、二村友史、浦本昌和、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Tolypocladium albumにおいてNPD938によって生産誘導されるpyridoxatinとF14329の生合成と生産制御の解析2019

    • Author(s)
      石井友彬、本山高幸、野川 俊彦、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 環化反応を触媒する新規ケトシンターゼドメインのX線結晶構造解析2019

    • Author(s)
      尹 忠銖、西本 一希、本山 高幸、日野 智也、永野 真吾、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pyricularia oryzaeにおけるpyriculol類生合成に関わるNADPH-dependent aldo/keto reductase (PYR7) の研究2019

    • Author(s)
      古山祐貴 、本山高幸、野川俊彦、清田洋正、鎌倉高志、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] イネいもち病菌のネクトリアピロン類の生産誘導と生理機能解析2019

    • Author(s)
      本山高幸、野川 俊彦、長田裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糸状菌Pleosporales sp. RKB3564の生産するpyrrolizilactone生合成経路の解析2019

    • Author(s)
      廣澤 早香、加藤 直樹、野川 俊彦、衣笠 清美、高橋 俊二、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Candida albicansに菌糸形態を誘導する化合物RK-276Aの有機合成2019

    • Author(s)
      山本 甲斐、二村 友史、清水 猛、 Rachael Uson-Lopez、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 糸状菌RK17-F0007より単離したBR-050立体異性体の構造と活性評価2019

    • Author(s)
      野川 俊彦、川谷 誠、岡野 亜紀子、青野 晴美、清水 猛、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 細胞形態変化を利用した抗真菌物質の探索2019

    • Author(s)
      二村 友史、Rachael Uson-Lopez、山本 甲斐、室井 誠、長田 裕之
    • Organizer
      日本農芸化学会2019年度大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Crystallization analysis of ketosynthase domain that responsible for cyclic skeleton formation of tenuazonic acid2018

    • Author(s)
      Choong-Soo Yun, Kazuki Nishimoto, Takayuki Motoyama, Tomoya Hino, Shingo Nagano, Hiroyuki Osada
    • Organizer
      The 9th Japan-Korea Chemical Biology Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Target identification of compounds isolated from a fraction library of fungal broths2018

    • Author(s)
      Hiroyuki Osada, Toshihiko Nogawa, Yushi Futamura, Makoto Muroi, Naoki Kato
    • Organizer
      3rd European Conference on Natural Products 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Induction of nectriapyrone biosynthesis in the rice blast fungus Pyricularia oryzae2018

    • Author(s)
      Takayuki Motoyama, Toshihiko Nogawa, Hiroyuki Osada
    • Organizer
      3rd European Conference on Natural Products 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Regulatory mechanism of mycotoxin tenuazonic acid biosynthesis in Pyricularia oryzae2018

    • Author(s)
      Choong-Soo Yun, Takayuki Motoyama, Hiroyuki Osada
    • Organizer
      3rd European Conference on Natural Products 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Timing of the mycotoxin, tenuazonic acid, produciton at the infection of plant pathogenic fungi2018

    • Author(s)
      Hiroyuki Osada
    • Organizer
      The Japanese-German Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] [4+2]環化付加反応におけるデカリン合成酵素Fsa2の機能解析2018

    • Author(s)
      加藤 直樹、野川 俊彦、滝田 良、衣笠 清美、金井 美紗衣、内山 真伸、長田 裕之、高橋 俊二
    • Organizer
      第60回天然有機化合物討論会
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 植物病原性糸状菌の二次代謝活性化から始める天然物研究2018

    • Author(s)
      本山 高幸
    • Organizer
      高磁場・高感度NMR利活用促進のための天然物分野シンポジウム2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] デカリン合成酵素遺伝子置換による非天然型天然物誘導体の創出2018

    • Author(s)
      加藤直樹、野川俊彦、衣笠清美、長田裕之、高橋俊二
    • Organizer
      第18回糸状菌分子生物学コンファレンス
    • Related Report
      2018 Annual Research Report
  • [Presentation] Pyrrolizilactone の生合成機構の解析2018

    • Author(s)
      廣澤早香、加藤直樹、衣笠清美、高橋俊二、長田裕之
    • Organizer
      第18回糸状菌分子生物学コンファレンス
    • Related Report
      2018 Annual Research Report
  • [Book] 天然物の化学Ⅱ(科学のとびら64)2018

    • Author(s)
      上村 大輔
    • Total Pages
      192
    • Publisher
      東京化学同人
    • ISBN
      9784807915057
    • Related Report
      2018 Annual Research Report
  • [Book] ケミカルバイオロジー化合物集 ―研究展開のヒント―2018

    • Author(s)
      日本学術振興会ケミカルバイオロジー第189委員会
    • Total Pages
      304
    • Publisher
      株式会社オーム社
    • ISBN
      9784274507090
    • Related Report
      2018 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗マラリア活性を示す新規生理活性物質及びその用途2021

    • Inventor(s)
      長田裕之、本山高幸、アブデルハキム イスラム アデル、二村友史
    • Industrial Property Rights Holder
      長田裕之、本山高幸、アブデルハキム イスラム アデル、二村友史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-034047
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] イネいもち病防除剤2019

    • Inventor(s)
      長田裕之、本山高幸、 清水猛、近藤恭光
    • Industrial Property Rights Holder
      長田裕之、本山高幸、 清水猛、近藤恭光
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-048574
    • Filing Date
      2019
    • Related Report
      2018 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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