| Project/Area Number |
18H03960
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Medium-sized Section 40:Forestry and forest products science, applied aquatic science, and related fields
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| Research Institution | Ehime University |
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Principal Investigator |
Miura Takeshi 愛媛大学, 農学研究科, 教授 (00261339)
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| Co-Investigator(Kenkyū-buntansha) |
三浦 智恵美 広島工業大学, 環境学部, 教授 (90518002)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥43,550,000 (Direct Cost: ¥33,500,000、Indirect Cost: ¥10,050,000)
Fiscal Year 2021: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Fiscal Year 2020: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2019: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2018: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 機能性多糖 / 昆虫 / 養殖 / 免疫 / 身質 / 肉質 / 高温耐性 / ゼブラフィッシュ / ブリ / 免疫賦活化 / カイコ / マダイ / シマアジ / バナメイエビ / 寄生虫症 |
|---|
| Outline of Final Research Achievements |
The effects of silkworm-derived functional polysaccharide, silkrose, were analyzed on fish and a method for its effective application in aquaculture was developed. The effect of silkrose on disease resistance in medaka (Oryzias latipes) and zebrafish (Danio rerio) was examined by challenge tests with pathogenic bacteria, Edwardsiella tarda, and disease resistance was improved in both species. Comprehensive gene expression analysis revealed significant changes in the expression of genes related to immune function, lipid metabolism, and oxidation-reduction in immune-related organs of both species. The effects of silkrose on white trevally and yellowtail in aquaculture were examined, and stress reduction, reduction of external parasites, reduction of mortality, and improvement of fish quality were observed, indicating the beneficial effects of the use of silkrose utilization in aquaculture.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、研究代表者のグループが世界に先駆け発見した昆虫由来の機能性多糖の魚類および甲殻類に対する作用とその機構を分子レベルで明らかにした新規性および進歩性が高い研究であり、学術的に意義のある研究である。また、学術研究の成果を実際の産業に応用することを目指した研究であり、水産養殖での効果的な利用法を提案することができた。本研究でその作用メカニズムおよび水産養殖での効果の詳細を調べたカイコ由来のシルクロースは、近年製品化され、既に多くの養殖生産者が使用し、養殖の効率化に貢献しており、本研究の社会的意義は大きい。
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