| Budget Amount *help |
¥44,330,000 (Direct Cost: ¥34,100,000、Indirect Cost: ¥10,230,000)
Fiscal Year 2020: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2019: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2018: ¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
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| Outline of Final Research Achievements |
Accurate gene expression is the basis of life phenomena, and its breakdown and abnormalities cause various diseases. Cells maintain the quality control mechanism RQC, which recognizes and eliminates abnormal translational elongation inhibition.
The ribosome is a significant hub during the maturation processes of protein synthesis. The quality control mechanism 18S NRD controls the quality of the ribosome. The principal investigator analyzed the molecular mechanism common to two quality control mechanisms, RQC and 18S NRD, caused by abnormal translation, and E3 ubiquitin ligase recognized a specific ribosome in a translationally arrested state and the ribosome protein. We have revealed that ubiquitination of ribosomes at specific residues plays a crucial role in determining ribosome dynamics and quality controls.
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