| Budget Amount *help |
¥44,720,000 (Direct Cost: ¥34,400,000、Indirect Cost: ¥10,320,000)
Fiscal Year 2020: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2018: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
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| Outline of Final Research Achievements |
Homeothermic animals maintain their body temperatures by the balance of the production and release of heat. Heat production in the animals is thought to involve shivering heat production in skeletal muscle and non-shivering heat production including heat production in brown adipose and beige adipose tissues and metabolic heat. Whereas the shivering heat production and metabolic heat are well understood, the detail of the non-metabolic non-shivering heat production remains still elusive. The present study has explored a previously-overlooked mechanism of the non-shivering heat production in which membrane potential drives ion flow through ion transporters such as ion channels and uncoupling protein 1, and the ion flow, one type of electric current, leads to Joule heat production, denoted as the Joule heat theory. This study conducted temperature imaging in cells and simulation of temperature distribution around channels to reveal the biological significance of this theory.
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