| Budget Amount *help |
¥44,070,000 (Direct Cost: ¥33,900,000、Indirect Cost: ¥10,170,000)
Fiscal Year 2021: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2020: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2019: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2018: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Outline of Final Research Achievements |
The various tissues/organs that make up our body consist of distinct types of cells. The nature of this different cell type is determined by the expression of different sets of genes. Which gene is turned ON or OFF in cells with different properties is regulated by the control of genome and acquired epigenome information. Epigenome information in the OFF state includes methylation of histone H3 lysine 9 residue (H3K9). In this study, we comprehensively analyzed what factors contribute to the control of the OFF state downstream of H3K9 methylation. As a result, we identified a number of novel factors in addition to the previously known factors. Currently, we are elucidating the role of these novel factors. Through this research, we would like to contribute to the development of a method to arbitrarily turn genes on and off.
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